79results about How to "Neuroprotective" patented technology

The invention relates to new use of 3-n-butylphthalide (abbreviated as butyl phthalide) and derivatives thereof, in particular to the use of the compounds in the preparation of the medicine for treating Parkinson disease. A mat model of hemiparkinsonian disease is built by using three-dimensional targeted injection of rotenone to perform a test, and the result of the test shows that the butyl phthalide and derivatives thereof can effectively improve symptoms aroused by Parkinson and have a nerve-protecting effect.

The invention belongs to the technical field of oral cavity nursing liquid, and relates to natural active bacterium restraining mouthwash by using marine oligosaccharides as a core component. The mouthwash comprises the components of the marine oligosaccharides, composite vitamins, semen sterculiae lychnophorae, a sweetening agent, a flavoring agent, potassium sorbate and water, wherein the marineoligosaccharides are small-molecular-weight carbohydrate substances extracted from marine animals and plants, and the sweetening agent is stevioside, licorice roots, disodium glycyrrhizinate or tripotassium glycyrrhizinate. The mouthwash disclosed by the invention is wide in application range and convenient to use, has the effects of cleaning teeth, restraining bacteria, resisting viruses, preventing tooth decay and promoting repairing of oral mucosa and does not have any toxic or side effects.

The invention relates to a polymer material with nerve tissue repair activity, and a preparing method and application of the polymer material. The polymer material is prepared from a hydrolysis product of monosialotetera-hexosyl ganglioside and a polylactic acid-glycolic acid copolymer (PLGA) which are connected through amido bonds, wherein the hydrolysis product of monosialotetera-hexosyl ganglioside is shown as a formula (I) (please see the specifications for the formula (I)). The polymer material has good biocompatibility, degradability and the mechanical property. Through the polymer material, the PLGA does not need to be loaded with various repair-promoting related factors, thus the nerve repair function can be achieved, thus a stent system prepared through the polymer material is simpler, later clinical application and storage are facilitated, and the polymer material is a bioactive material with clinical application prospects.

The invention discloses application of PD149163 to preparation of medicine for treating cerebral arterial thrombosis. According to application of PD149163 to preparation of the medicine for treating cerebral arterial thrombosis, on the premise that cerebral blood flow of a focal zone is not affected in the cerebra ischemic reperfusion process, PD149163 plays a protective role in rat cerebral injury at the acute stage caused by focal cerebra ischemic reperfusion. PD149163 possibly resists to nerve cell apoptosis caused at the acute stage of cerebra ischemic reperfusion by blocking an AMPK-mTOR signal channel and inhibiting autophagy.

The invention belongs to the field of mosquito-repellent incenses, and in particular relates to a nepenthes extract mosquito-repellent liquid and a preparation method thereof. The nepenthes extract mosquito-repellent liquid is prepared from the following raw materials in parts by weight: 110-160 parts of a nepenthes extracting solution, 67-94 parts of a wormwood extracting solution, 33-51 parts of a lantana camara extract solution, 8-20 parts of a lavender extract solution, 40-60 parts of deionized water and 30-55 parts of ethanol. The preparation method comprises the following steps: performing ultrasonic treatment, eccentric treatment, concentration treatment and the like so as to prepare the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution and the lavender extracting solution, mixing the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution, the lavender extracting solution, deionized water and ethanol, and performing sealed stirring for 3-6 hours at 53-70 DEG C to obtain the nepenthes extract mosquito-repellent liquid. Effective components of the nepenthes extract mosquito-repellent liquid are all extracted from natural traditional Chinese herbal medicines which are relatively low in cost, so that the prepared product is safe and non-toxic and has the effects of killing bacteria, repelling mosquitoes and helping sleep.

The invention discloses a (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound and a preparation method thereof. By using dichloromethane or tetrahydrofuran as a solvent and triethylamine as an acid binding agent, chloracetyl chloride and resveratrol used as reactants are subjected to esterification reaction at 0-28 DEG C for 2-5 hours to obtain the white solid (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound. The (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound has stable structure, and can not be easily oxidized; the preparation method has the characteristic of simple preparation process and is convenient to operate; and meanwhile, the obtained (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound has similar structural features to resveratrol, and reserves the group having drug effect in the resveratrol.

The invention provides an acne-removing and grease-controlling mask lotion and a making method thereof, and belongs to the field of daily chemicals. Main raw materials of such an acne-removing and grease-controlling mask lotion particularly comprise the following substances in parts by weight: 25 to 30 parts of fructus alpiniae oxyphyllae, 20 to 25 parts of radix paeoniae rubra, 12 to 20 parts of herba iridis japonicae, 16 to 20 parts of flos lonicerae, 10 to 15 parts of fructus forsythiae, 13 to 20 parts of poria cocos, 10 to 20 parts of radix angelicae sinensis, 15 to 20 parts of herba taraxaci, 16 to 20 parts of aloe, 10 to 15 parts of radix scutellariae, 20 to 25 parts of radix glycyrrhizae and 150 to 200 parts of purified water. The main raw materials of such a mask lotion provided by the invention are healthy, natural, safe and reliable; components are mild without irritation; the components synergistically act; the acne-removing and grease-controlling mask lotion has acne-removing and grease-controlling functions, and when being used for a long time, can be used for regulating the water-grease equilibrium of a skin, and makes the skin gradually recover health.

Provided are a use of 5α-androstane-3β,5,6β-triol and analogues thereof in the preparation of a drug for treating or preventing altitude sickness induced by hypobaric hypoxia.

The invention discloses a sulfhydryl compound serving as a histone deacetylase inhibitor, and an application thereof. Pharmacological experiment results show that the composition has high anti-proliferative activity on various tumor cells, shows a protective effect on glutamic acid-induced neuronal cell damage on a cell model, has low toxicity to normal cells, low potential cardiotoxicity, ideal pharmacokinetic characteristics and high blood-brain barrier permeability, and has a development prospect as a high-efficiency low-toxicity antitumor or neurodegenerative disease treatment agent. The sulfhydryl compound is a compound with a structural general formula represented by formula (I) shown in the description, or a pharmaceutically acceptable salt, an ester or a prodrug thereof.

The invention relates to application of a compound in preparation of drugs for resisting picornavirus. The compound can effectively inhibit the drugs for resisting picornavirus, has a good inhibitingeffect on human enterovirus 71 (EV-A71), can be used for treating various diseases caused by drugs for resisting picornavirus infection, is especially used for treating hand-foot-mouth disease, and isexpected to solve the dilemma that the hand-foot-mouth disease is not targeted clinically. In addition, the compound disclosed by the invention is derived from a natural extract and is high in safety.

The invention discloses a new skeleton large ring mixed peptide polyketide and a preparation method and application thereof. The invention provides the compound shown as a formula I (please see the specification for the formula I), or a stereoisomer, a crystal form or a pharmaceutically acceptable salt thereof, wherein in the formula I, R is selected from hydrogen, hydroxyl, halogen, C1-C4 alkoxyand C1-C6 alkyl. The invention further provides the preparation method and application of the compound. Experimental results prove that the compound provided by the invention can inhibit apoptosis ofnerve cells, has a neuroprotective effect, can be used as a potential drug for preventing and treating neurodegenerative diseases, and provides a new drug option for clinical application.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing or treating neurodegenerative diseases. The traditional Chinese medicine composition is prepared from leeches, ligusticum wallichii, salvia miltiorrhiza and astragalus membranaceus. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and tonifying qi and dredging collaterals, and can effectively improve general behavioral performance, enhance balance coordination ability and autonomous activity ability, relieve motion retardation symptoms, relieve anxiety mood and obviously increase the number of nigra TH + cells; in addition, the traditional Chinese medicine composition can effectively treat the Parkinson's disease, reduces or delays the loss of dopaminergic neurons of the midbrain, has a neuroprotective effect and is free of liver and kidney function damage. The composition has a remarkable effect on treating the Parkinson's disease, is safe and effective, and has a good popularization and application prospect.

The invention belongs to the technical field of nano-materials, and discloses a method for preparing nano-selenium by compounding a polyphenol compound and protein and the prepared nano-selenium. The method comprises the following steps: (1) compounding a polyphenol compound and protein into a soft template: uniformly mixing a protein solution with a certain concentration with a polyphenol compound solution, and directly using or freeze-drying for use; and (2) preparing nano-selenium by using the polyphenol-protein soft template: adding a vitamin C solution into a reaction system in which the polyphenol-protein soft template exists, uniformly mixing, then adding a sodium selenite solution, uniformly stirring and mixing, standing the obtained mixed reaction system for reduction reaction to obtain nano-selenium sol, dialyzing or centrifugally separating to obtain nano-selenium suspension, and freeze-drying to obtain the nano-selenium solid. According to the invention, the polyphenol compound and the protein are compounded into the soft template, so that the functional characteristics of the nano-selenium are enhanced, the stability of the nano-selenium is also enhanced, the application field of the nano-selenium is widened, and the application value of the nano-selenium is improved.

The invention relates to compounds with a neuroprotective effect, and a preparation method and application thereof. Specifically, the compounds disclosed by the invention have a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses the preparation method of the compounds and application of the compounds in neuroprotection.