79results about How to "Neuroprotective" patented technology

The invention relates to new use of 3-n-butylphthalide (abbreviated as butyl phthalide) and derivatives thereof, in particular to the use of the compounds in the preparation of the medicine for treating Parkinson disease. A mat model of hemiparkinsonian disease is built by using three-dimensional targeted injection of rotenone to perform a test, and the result of the test shows that the butyl phthalide and derivatives thereof can effectively improve symptoms aroused by Parkinson and have a nerve-protecting effect.

The invention belongs to the technical field of bio-imaging, and discloses a compound, an aggregation-induced emission probe and a preparation method and application thereof. The compound is shown inthe formula III or IV, and the aggregation-induced emission probe contains at least one of the compounds shown in the formula III or IV. The invention further discloses preparation methods of the compounds shown in the formula III and IV. The compound can effectively overcome the defect of aggregation induction quenching of traditional fluorescent pigment, achieves specificity and high signal to noise ratio fluorescent imaging of A beta plaques, has the advantages including high emission efficiency and large stokes shift, can serve as the aggregation-induced emission probe, and has the neuralprotection effect. In addition, the invention further discloses application of the compound to A beta plaque specificity fluorescence imaging agent and neural cell protection and monitoring of formingof A beta fiber or depolymerization of A beta fiber. (The formulas are shown in the description.).

The invention discloses a histone deacetylase subtype inhibitor, namely a thioacetyl arylamine compound and application thereof. Pharmacological experiments show that the compound has a selective inhibition effect on HDAC6 enzyme, shows high anti-proliferative activity on various tumor cells, and is low in toxicity to normal cells and low in potential cardiotoxicity. Moreover, the compound has a protective effect on nerve cells, is ideal in pharmacokinetic characteristics, and has relatively high blood-brain barrier dredging characteristics. The compound disclosed by the invention has a deep development prospect as a high-efficiency low-toxicity anti-tumor or neurodegenerative disease therapeutic agent. The structural general formula of the histone deacetylase subtype inhibitor, namely thethioacetyl arylamine compound is as shown in the specification.

The invention belongs to the technical field of oral cavity nursing liquid, and relates to natural active bacterium restraining mouthwash by using marine oligosaccharides as a core component. The mouthwash comprises the components of the marine oligosaccharides, composite vitamins, semen sterculiae lychnophorae, a sweetening agent, a flavoring agent, potassium sorbate and water, wherein the marineoligosaccharides are small-molecular-weight carbohydrate substances extracted from marine animals and plants, and the sweetening agent is stevioside, licorice roots, disodium glycyrrhizinate or tripotassium glycyrrhizinate. The mouthwash disclosed by the invention is wide in application range and convenient to use, has the effects of cleaning teeth, restraining bacteria, resisting viruses, preventing tooth decay and promoting repairing of oral mucosa and does not have any toxic or side effects.

The invention relates to the technical field of food and traditional Chinese medicines and provides a preparation method and applications of three novel compounds extracted and separated from paeoniaanomala. Chemical structural formulas of the compounds are shown in formulas (I), (II) and (III). Dried root tubers of paeonia anomala are crushed and then subjected to heating reflux extraction with80% ethanol, a total extract obtained through reduced pressure concentration is dispersed with water, extraction is performed with petroleum ether, ethyl acetate and water-saturated n-butyl alcohol with the same volume respectively, and parts are obtained. The n-butyl alcohol part is dissolved with water, macroporous resin column chromatography is performed, and fractions are obtained; the 30% ethanol part is separated and purified through silica gel column chromatography, a target chromatographic liquid is collected, separation with a C18 reversed phase chromatographic column and purificationwith Sephadex LH-20 (hydroxypropyl sephadex) are performed, and the compounds I, II and III are obtained. The invention also provides applications of the three compounds in neuroprotection and neurodegenerative disease treatment.

The invention relates to a polymer material with nerve tissue repair activity, and a preparing method and application of the polymer material. The polymer material is prepared from a hydrolysis product of monosialotetera-hexosyl ganglioside and a polylactic acid-glycolic acid copolymer (PLGA) which are connected through amido bonds, wherein the hydrolysis product of monosialotetera-hexosyl ganglioside is shown as a formula (I) (please see the specifications for the formula (I)). The polymer material has good biocompatibility, degradability and the mechanical property. Through the polymer material, the PLGA does not need to be loaded with various repair-promoting related factors, thus the nerve repair function can be achieved, thus a stent system prepared through the polymer material is simpler, later clinical application and storage are facilitated, and the polymer material is a bioactive material with clinical application prospects.

The invention discloses an application of an miRNA 148 cluster as a marker for diagnosis and / or treatment of cognitive disorder related diseases. The invention provides the application of miRNA 148 cluster microRNA in diagnosis and treatment of cognitive disorder related diseases, and the expression quantity of the miRNA 148 cluster microRNA is detected through a cognitive disorder disease model by using a primer of a microRNA marker aiming at the miRNA 148 cluster. It is found that expression of microRNA of the miRNA 148 cluster is remarkably reduced in the course of cognitive disorder related diseases, tau protein overphosphorylation in AD lesions is inhibited through negative regulation of the PTEN gene and targeting of p35, and the AD pathology course is improved. Therefore, the microRNA of the miRNA 148 cluster can be used as a novel marker of cognitive disorder related diseases and is used for auxiliary diagnosis and treatment of the cognitive disorder related diseases.

The invention provides application of mesenchymal stem cell derived extracellular vesicles to cerebral ischemia-reperfusion injury. Research of the invention finds and verifies that extracellular vesicles (MSCs-EVs) derived from mesenchymal stem cells are capable of treating disordered brain functions and taking a neuroprotective effect into play through neurogenesis and angiogenesis after stroke.Research results show that within 24 hours and 48 hours after MCAO (middle cerebral artery occlusion), MSCs-EVs are capable of remarkably reliving neurologic impairment of rats, reducing the volume of cerebral infarction and brain water contents, relieving pathological injury of brain tissue cortexes, weakening cortex neuronal apoptosis, remarkably increasing p-AMPK (protein kinase), and reducingp-JAK2, p-STAT3 and p-NF-kB. Due to the application, essential support is provided for potential treatment strategies of MSCs-EVs as MCAO treatment.

The invention discloses application of PD149163 to preparation of medicine for treating cerebral arterial thrombosis. According to application of PD149163 to preparation of the medicine for treating cerebral arterial thrombosis, on the premise that cerebral blood flow of a focal zone is not affected in the cerebra ischemic reperfusion process, PD149163 plays a protective role in rat cerebral injury at the acute stage caused by focal cerebra ischemic reperfusion. PD149163 possibly resists to nerve cell apoptosis caused at the acute stage of cerebra ischemic reperfusion by blocking an AMPK-mTOR signal channel and inhibiting autophagy.

The invention belongs to the field of mosquito-repellent incenses, and in particular relates to a nepenthes extract mosquito-repellent liquid and a preparation method thereof. The nepenthes extract mosquito-repellent liquid is prepared from the following raw materials in parts by weight: 110-160 parts of a nepenthes extracting solution, 67-94 parts of a wormwood extracting solution, 33-51 parts of a lantana camara extract solution, 8-20 parts of a lavender extract solution, 40-60 parts of deionized water and 30-55 parts of ethanol. The preparation method comprises the following steps: performing ultrasonic treatment, eccentric treatment, concentration treatment and the like so as to prepare the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution and the lavender extracting solution, mixing the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution, the lavender extracting solution, deionized water and ethanol, and performing sealed stirring for 3-6 hours at 53-70 DEG C to obtain the nepenthes extract mosquito-repellent liquid. Effective components of the nepenthes extract mosquito-repellent liquid are all extracted from natural traditional Chinese herbal medicines which are relatively low in cost, so that the prepared product is safe and non-toxic and has the effects of killing bacteria, repelling mosquitoes and helping sleep.

The invention discloses a (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound and a preparation method thereof. By using dichloromethane or tetrahydrofuran as a solvent and triethylamine as an acid binding agent, chloracetyl chloride and resveratrol used as reactants are subjected to esterification reaction at 0-28 DEG C for 2-5 hours to obtain the white solid (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound. The (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound has stable structure, and can not be easily oxidized; the preparation method has the characteristic of simple preparation process and is convenient to operate; and meanwhile, the obtained (E)-3-hydroxy-5-(hydroxystyryl)-2-phenyl chloroacetate compound has similar structural features to resveratrol, and reserves the group having drug effect in the resveratrol.

The invention provides an acne-removing and grease-controlling mask lotion and a making method thereof, and belongs to the field of daily chemicals. Main raw materials of such an acne-removing and grease-controlling mask lotion particularly comprise the following substances in parts by weight: 25 to 30 parts of fructus alpiniae oxyphyllae, 20 to 25 parts of radix paeoniae rubra, 12 to 20 parts of herba iridis japonicae, 16 to 20 parts of flos lonicerae, 10 to 15 parts of fructus forsythiae, 13 to 20 parts of poria cocos, 10 to 20 parts of radix angelicae sinensis, 15 to 20 parts of herba taraxaci, 16 to 20 parts of aloe, 10 to 15 parts of radix scutellariae, 20 to 25 parts of radix glycyrrhizae and 150 to 200 parts of purified water. The main raw materials of such a mask lotion provided by the invention are healthy, natural, safe and reliable; components are mild without irritation; the components synergistically act; the acne-removing and grease-controlling mask lotion has acne-removing and grease-controlling functions, and when being used for a long time, can be used for regulating the water-grease equilibrium of a skin, and makes the skin gradually recover health.

Provided are a use of 5α-androstane-3β,5,6β-triol and analogues thereof in the preparation of a drug for treating or preventing altitude sickness induced by hypobaric hypoxia.

The invention discloses a sulfhydryl compound serving as a histone deacetylase inhibitor, and an application thereof. Pharmacological experiment results show that the composition has high anti-proliferative activity on various tumor cells, shows a protective effect on glutamic acid-induced neuronal cell damage on a cell model, has low toxicity to normal cells, low potential cardiotoxicity, ideal pharmacokinetic characteristics and high blood-brain barrier permeability, and has a development prospect as a high-efficiency low-toxicity antitumor or neurodegenerative disease treatment agent. The sulfhydryl compound is a compound with a structural general formula represented by formula (I) shown in the description, or a pharmaceutically acceptable salt, an ester or a prodrug thereof.

The invention relates to application of a compound in preparation of drugs for resisting picornavirus. The compound can effectively inhibit the drugs for resisting picornavirus, has a good inhibitingeffect on human enterovirus 71 (EV-A71), can be used for treating various diseases caused by drugs for resisting picornavirus infection, is especially used for treating hand-foot-mouth disease, and isexpected to solve the dilemma that the hand-foot-mouth disease is not targeted clinically. In addition, the compound disclosed by the invention is derived from a natural extract and is high in safety.

A hericium erinaceus mycelium polysaccharide with the effect of preventing and treating senile dementia and a preparation method are disclosed. Hericium erinaceus mycelium obtained through a liquid submerged fermentation technology serves as a raw material, the neuroprotective effect serves as an evaluation standard, and the novel purified hericium erinaceus mycelium polysaccharide is obtained through extraction, separation and purification, and is composed of six monosaccharides including fucose, galactose, xylose, glucose, mannose and glucuronic acid; and experiments prove that in APP / PS1 mice, the hericium erinaceus mycelium purified polysaccharide obtained in the invention can obviously shorten platform searching time and movement distance of the mice, improve platform jumping staying time of the mice, and reduce platform jumping-off times, and has effects of improving the cognition and memory ability of APP / PS1 mice, effectively reducing the levels of Abeta1-42, Tau (phospo S396) and 4-HNE in hippocampal regions of the mice, relieving AD pathological symptoms and improving the cholinergic system and the antioxidant ability.

The invention discloses a biological agent with the neuroprotective effect. A temperature sensitive hydrogel coats an activin B to obtain a composite biological agent. The activin B has neuroprotective effect, the novel temperature sensitive hydrogel has neuroprotective effect, and functions of inflammation inhibition and slow release; the activin B in the composite biological agent slowly releases in the brain to play drug effect. The biological agent can synergistically inhibit mice corpus striatum dopaminergic neuron injury caused by Mptp, reduce local inflammation reaction, and improve the symptoms of Parkinson's disease from the perspective of behavioristics. The invention provides important medication reference for the clinic treatment of Parkinson's disease and other neurodegeneration diseases.

The invention discloses a drug for potentially treating Parkinson's disease and belongs to the technical field of medical neuropharmacology. The invention finds the potential application of an iridoid glycoside compound aucubin in the drug for clinically treating Parkinson's disease. According to the invention, a Parkinson's disease animal model is established, various research methods, such as, behavioristics, immunology and biochemical criterion, are comprehensively utilized and an experiment proves that the drug can improve the dyskinesia symptom of a Parkinson's disease model rat; the decreasing of the content of corpus striatum dopamine is reduced; the dopaminergic neuron degeneration of the compact part of substantia nigra is reduced; the aucubin material source is abundant and the effect is excellent, so that the drug has a certain development value and prospect in clinical application.

The invention discloses a new skeleton large ring mixed peptide polyketide and a preparation method and application thereof. The invention provides the compound shown as a formula I (please see the specification for the formula I), or a stereoisomer, a crystal form or a pharmaceutically acceptable salt thereof, wherein in the formula I, R is selected from hydrogen, hydroxyl, halogen, C1-C4 alkoxyand C1-C6 alkyl. The invention further provides the preparation method and application of the compound. Experimental results prove that the compound provided by the invention can inhibit apoptosis ofnerve cells, has a neuroprotective effect, can be used as a potential drug for preventing and treating neurodegenerative diseases, and provides a new drug option for clinical application.

The invention relates to an erythrocyte generating characteristic-free erythropoietin with a nervous protecting function and an application thereof. The erythropoietin is an allosteric variant generated by the mutation of at least one of the three areas and other 28 interspersed loci of a wild type human erythropoietin and the three areas are as follows: (1) VLQRY: No. 11-15 amino acid of the human erythropoietin; (2) TKVNFYAW: No. 44-51 amino acid of the human erythropoietin; and (3) SGLRSLTTL: No. 100-108 amino acid of the human erythropoietin. The invention has the nervous protecting function but does not have the erythrocyte generating function, prevents the formation of secondary thrombus caused by general erythropoietin and improves the safety of clinical application; the treatment crowd is expanded so that a cerebral apoplexy patient which has higher blood viscosity and can not carry out treatment by the general erythropoietin is treated; and the invention sill has the effect ofobviously improving the nervous function by being taken after 48 hours and can be injected for a long time without simulating the blood system.

The invention provides a natural efficient anti-hair-loss hair restorer. A formula of the natural efficient anti-hair-loss hair restorer comprises cannabidiol crude oil, Morocco nut oil, frankincenseoil, tea tree oil, castor oil, bergamot oil and cannabis oil. Raw materials are weighed according to the formula, the raw materials are put into a mixing kettle to be stirred for 10-15 minutes at thetemperature of 35-39 DEG C to enable the raw materials to be in a homogenate state, still standing is conducted for two hours to obtain the natural efficient anti-hair-loss hair restorer, and bottlingis conducted by using a rubber head dropper tool. The natural efficient anti-hair-loss hair restorer is prepared by taking the cannabidiol crude oil as the main raw material, cannabidiol acts on receptors such as the CB1 receptor, the TRPV1 receptor and the 5-HT1A receptor in a human body, thus the activity of 5-alpha reductase is inhibited advantageously, androgen can be generated after the 5-alpha reductase is controlled to react with and testosterone in the human body, and thus the aim of treating alopecia is fulfilled by reducing the androgen level.

The invention discloses a method for determining mangiferin in common bombax flower and a quality evaluation method of common bombax flower, and belongs to the field of drug detection. The method fordetermining mangiferin in common bombax flower comprises the following steps that a proper amount of pure mangiferin is taken and added with 60% methanol to prepare a contrast solution, and 1ml of thecontrast solution includes 20 microgram of mangiferin; 0.5g of common bombax flower sample powder is taken and added with 25ml of 60% methanol, the weight is measured, ultrasonic processing is carried out for 1 hour, cooling is carried out, the weight is measured again, 60% of methanol is used to supplement the reduced weight, a mixture is shaken up and filtered, a subsequent filtrate is taken, and a solution to be detected is obtained; and 10 microliter of the contrast solution and 10 microliter of the solution to be detected are sucked and injected to a liquid chromatograph, and the contentof mangiferin is obtained via a content determination method. The chromatographic peak of the contrast solution is compared with that of the solution to be detected for calculation to obtain the content of mangiferin in common bombax flower conveniently. The quality of the common bombax flower can be also evaluated effectively.

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing or treating neurodegenerative diseases. The traditional Chinese medicine composition is prepared from leeches, ligusticum wallichii, salvia miltiorrhiza and astragalus membranaceus. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and tonifying qi and dredging collaterals, and can effectively improve general behavioral performance, enhance balance coordination ability and autonomous activity ability, relieve motion retardation symptoms, relieve anxiety mood and obviously increase the number of nigra TH + cells; in addition, the traditional Chinese medicine composition can effectively treat the Parkinson's disease, reduces or delays the loss of dopaminergic neurons of the midbrain, has a neuroprotective effect and is free of liver and kidney function damage. The composition has a remarkable effect on treating the Parkinson's disease, is safe and effective, and has a good popularization and application prospect.

The invention relates to a phenyl 2-piperazine ethyl carbamate derivative and a pharmaceutical application thereof. The structure of the phenyl 2-piperazine ethyl carbamate derivative accords with a general formula (I), wherein R is -H or-CH3. The drug has good water solubility, can rapidly release ZL006-05 in vivo, can maintain a high blood concentration of ZL006-05, and has a neuroprotective effect similar to that of ZL006-05 and a better nerve repair promoting effect. The derivative can be used for preparing medicines for treating cerebral apoplexy, neuropathic pain and other diseases.

The invention relates to the technical field of traditional Chinese medicines, in particular to a biflavone compound extracted from maidenhair flowers as well as a preparation method and application thereof. The molecular formula of the biflavone compound is C33H24O16, the biflavone compound is named as 8,8'-methylene bis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone, the chemical structural formula of the biflavone compound is shown in the specification, and the biflavone compound is used for preparing neuroprotective drugs. The preparation method sequentially comprises the following steps: ethanol extraction, n-butyl alcohol extraction, silica gel column chromatography, polyamide, and Sephadex LH-20. According to the method, the biflavone compound with high purity can be simply, conveniently and quickly extracted and separated, has a neuroprotective effect, can be prepared into tablets, granules, capsules and other dosage forms by being supplemented with pharmaceutically common auxiliary materials, and is used for improving and treating depression and other neurological diseases. Therefore, the biflavone compound can be used as a natural product to develop new drugsof traditional Chinese medicines, and has a wide application prospect.

The invention discloses an application of astilbin in an aspect of preventing and treating Parkinson's disease, and belongs to the technical field of medical neuropharmacology. The invention relates to a potential application of a dihydroflavonol glycoside compound, namely the astilbin, in preparing a medicine for the clinical treatment of the Parkinson's disease. According to the application, by establishing an animal model of the Parkinson's disease and through the comprehensive utilization of various research methods including ethology, immunology, biochemical indexes and the like, experiments prove that the medicine can improve dyskinesia symptom in a model mouse of the Parkinson's disease and can relieve the degeneration of dopaminergic neuron of substantia nigra pars compacta; and the astilbin, which is rich in raw material source and good in effect, has a certain development value and a certain prospect in clinical application.

The invention belongs to the technical field of nano-materials, and discloses a method for preparing nano-selenium by compounding a polyphenol compound and protein and the prepared nano-selenium. The method comprises the following steps: (1) compounding a polyphenol compound and protein into a soft template: uniformly mixing a protein solution with a certain concentration with a polyphenol compound solution, and directly using or freeze-drying for use; and (2) preparing nano-selenium by using the polyphenol-protein soft template: adding a vitamin C solution into a reaction system in which the polyphenol-protein soft template exists, uniformly mixing, then adding a sodium selenite solution, uniformly stirring and mixing, standing the obtained mixed reaction system for reduction reaction to obtain nano-selenium sol, dialyzing or centrifugally separating to obtain nano-selenium suspension, and freeze-drying to obtain the nano-selenium solid. According to the invention, the polyphenol compound and the protein are compounded into the soft template, so that the functional characteristics of the nano-selenium are enhanced, the stability of the nano-selenium is also enhanced, the application field of the nano-selenium is widened, and the application value of the nano-selenium is improved.

The invention relates to compounds with a neuroprotective effect, and a preparation method and application thereof. Specifically, the compounds disclosed by the invention have a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses the preparation method of the compounds and application of the compounds in neuroprotection.