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Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating nervous system diseases

A technology for nervous system diseases and compositions, which is applied in the field of preparation of drugs for the prevention or treatment of nervous system diseases, and the field of traditional Chinese medicine compositions, and can solve problems such as high risk of brain damage, exacerbation of the disease, and inability to cure them

Pending Publication Date: 2021-07-27
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical application response of levodopa preparations, although it can improve the symptoms of Parkinson's disease, with the prolonged administration time, it has toxic side effects on dopamine nerves, which will lead to the generation of cytotoxic free radicals, and then destroy the undead cells. Dopamine neurons, leading to aggravation of the disease, can not be cured
In addition, surgical treatment (neuronuclear destruction and deep brain stimulation, etc.) can only be used as the first choice of drug treatment because of its high risk of brain damage and no significant improvement in axial symptoms such as abnormal posture, gait, and dysphagia. Complementary Treatment

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating nervous system diseases
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating nervous system diseases
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing or treating nervous system diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] The preparation of embodiment 1 Chuanzhitongluo granules

[0137] Leech 550g Chuanxiong 550g

[0138] Danshen 400g Astragalus 400g

[0139] A. The leech is crushed into a coarse powder, add 2 times the amount of water, stir and extract at 100r / min at 37°C for 24h, centrifuge at 6000r / min for 30min, take the supernatant and pass it through a 1μm filter membrane for pre-filtration, and then pass through a 0.2μm filter membrane Sterilize, then concentrate through 6-10kDa ultrafiltration, freeze-dry the concentrated solution, and pulverize to obtain leech freeze-dried powder for subsequent use;

[0140] B. Rhizoma Chuanxiong, Salvia Miltiorrhiza and Radix Astragalus add 10 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, filter and concentrate the reflux to obtain an alcohol concentrate with a relative density of 1.1 at 50°C, and add 4 times the raw material to the dregs amount of water, decocting and extracting for 1 hour, filtering, co...

Embodiment 2

[0142] The preparation of embodiment 2 Chuanzhi Tongluo Tablets

[0143] Leech 600g Chuanxiong 600g

[0144] Danshen 400g Astragalus 400g

[0145] A. The leech is crushed into a coarse powder, add 6 times the amount of water, stir and extract at 100r / min at 37°C for 24h, centrifuge at 6000r / min for 30min, take the supernatant and pass it through a 1μm filter membrane for pre-filtration, and then pass it through a 0.2μm filter membrane Sterilize, then concentrate through 6-10kDa ultrafiltration, freeze-dry the concentrated solution, and pulverize to obtain leech freeze-dried powder for subsequent use;

[0146] B. Rhizoma Chuanxiong, Salvia Miltiorrhiza and Radix Astragali, add 5 times the amount of 70% ethanol to reflux and extract twice, each time for 2 hours, filter and concentrate the reflux to obtain an alcohol concentrate with a relative density of 1.3 at 50°C, add the dregs of the raw materials for 3 times amount of water, decocting and extracting for 1 hour, filtering,...

Embodiment 3

[0148] The preparation of embodiment 3 Chuanzhi Tongluo Capsules

[0149] Leech 600g Chuanxiong 600g

[0150] Danshen 400g Astragalus 400g

[0151] A. The leeches are crushed into coarse powder, add 8 times the amount of water, stir and extract at 100r / min at 37°C for 24h, centrifuge at 6000r / min for 30min, take the supernatant and pass it through a 1μm filter membrane for pre-filtration, and then pass through a 0.2μm filter membrane Sterilize, then concentrate through 6-10kDa ultrafiltration to a relative density of 1.15, freeze-dry the concentrated solution, and pulverize to obtain leech freeze-dried powder for later use;

[0152] B. Rhizoma Chuanxiong, Salvia Miltiorrhiza and Radix Astragali, add 6 times the amount of 80% ethanol to reflux and extract twice, each time for 2 hours, filter and concentrate the reflux to obtain an alcohol concentrate with a relative density of 1.2 at 50°C, add 4 times the raw material to the dregs amount of water, decocting and extracting for...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing or treating neurodegenerative diseases. The traditional Chinese medicine composition is prepared from leeches, ligusticum wallichii, salvia miltiorrhiza and astragalus membranaceus. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and tonifying qi and dredging collaterals, and can effectively improve general behavioral performance, enhance balance coordination ability and autonomous activity ability, relieve motion retardation symptoms, relieve anxiety mood and obviously increase the number of nigra TH + cells; in addition, the traditional Chinese medicine composition can effectively treat the Parkinson's disease, reduces or delays the loss of dopaminergic neurons of the midbrain, has a neuroprotective effect and is free of liver and kidney function damage. The composition has a remarkable effect on treating the Parkinson's disease, is safe and effective, and has a good popularization and application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the use of a traditional Chinese medicine composition in preparing medicines for preventing or treating nervous system diseases. Background technique [0002] Nervous system degenerative diseases are a type of irreversible neurological diseases caused by the loss of neuron cells in the brain and spinal cord, mainly including Alzheimer's disease, Parkinson's syndrome, atrophic lateral sclerosis, Huntington's disease, etc. As society ages, the incidence of neurodegenerative diseases continues to rise, resulting in huge social medical consumption and family pressure. [0003] Parkinson's disease is a neurodegenerative disease common in middle-aged and elderly people. The dopamine neurons in the substantia nigra of the affected patients degenerate and die, causing a significant decrease in the content of dopamine in the substantia nigra of the striat...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P25/28A61P25/00A61P25/08A61P9/10A61P25/16A61K35/62
CPCA61K9/0053A61K35/62A61K36/236A61K36/481A61K36/537A61P9/10A61P25/00A61P25/08A61P25/16A61P25/28A61K2300/00
Inventor 张贵民张微韩振明
Owner LUNAN PHARMA GROUP CORPORATION
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