39results about How to "Improve pathology" patented technology

The invention relates to new use of 3-n-butylphthalide (abbreviated as butyl phthalide) and derivatives thereof, in particular to the use of the compounds in the preparation of the medicine for treating Parkinson disease. A mat model of hemiparkinsonian disease is built by using three-dimensional targeted injection of rotenone to perform a test, and the result of the test shows that the butyl phthalide and derivatives thereof can effectively improve symptoms aroused by Parkinson and have a nerve-protecting effect.

A traditional Chinese medicine comprehensive physical rehabilitation therapeutic instrument comprises a therapeutic instrument body, wherein the therapeutic instrument body comprises a laser output module, an ultrasonic wave output module, a thermal therapy output module, a pulse output module and a music output module, the therapeutic instrument body further comprises a control module, and the control module is connected with a laser controller, an ultrasonic wave controller, a heating controller and a pulse controller. Treatment is conducted based on combination of traditional Chinese medicine and physical rehabilitation, the theory of traditional Chinese medicine and the modern physiotherapy technique, and physical factors directly act on local parts of human body and indirectly act on nerves and acupoints to cause body reaction, so that blood circulation is regulated, metabolism is accelerated, cell tissue repair is promoted, immunity is improved, pathogenic factors are eliminated, and pathological process is improved.

The invention discloses a traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis. Active pharmaceutical ingredients of the traditional Chinese medicine composition comprise, by weight, 10-15 parts of the root of red-rooted salvia, 10-60 parts of astragalus membranaceus, 10-30 parts of herba epimedii, 5-30 parts of sinensis and 3-30 parts of prepared rhubarb. Clinical researches show that 168 patients with chronic renal insufficiency are treated by the traditional Chinese medicine composition, a remarkable clinical effect is obtained, clinical symptoms are reduced, the clinical symptoms of some patients are basically eliminated, the renal functions of the patients can be remarkably improved, blood urea nitrogen (BUN) and creatinine (Scr) are obviously reduced, and total effective rate achieves 88.66%. Animal researches show that the traditional Chinese medicine composition can delay development of chronic renal failure, and the mechanism of the traditional Chinese medicine composition is relative to effects of effectively restraining precipitation of renal tissue collagen and secretion of TGF (transforming growth factor)-beta, accordingly restraining renal fibrosis, and the like. The traditional Chinese medicine composition is low in clinical application cost and excellent in curative effect, and is safe and reliable.

The invention belongs to the field of food processing and particularly relates to blend oil and a preparation method thereof. The blend oil disclosed by the invention comprises hemp oil, camellia oil and corn oil. The blend oil disclosed by the invention has the advantages that according to the characteristic that different natural vegetable oils contain fatty acids with different kinds and amounts and on the basis of the human fatty acid balance principle, the hemp oil, the camellia oil and the corn oil are scientifically mixed to form the nutritional blend oil which has the advantages of specifically adjusting and improving physiology and pathology of a human body and meeting the requirements of the health of the human body; in addition, the preparation method disclosed by the invention is simple in process and extremely high in popularization valve.

The invention provides safety cigarettes. In the manufacturing process of the safety cigarettes, nano selenium and short peptide collagen are added into cut tobacco, wherein the nano selenium accounts for 0.00025 to 0.003125 percent of the total weight of the cut tobacco; and the short peptide collagen accounts for 2 to 5 percent of the total weight of the cut tobacco. When the additive disclosed by the invention is added, the final finished cigarettes have the characteristics that: the toxicity of smoke is reduced obviously, and the average cell lethal dosage of the smoke of the cigarettes is increased obviously; unfavorable change induced by the smoke of the cigarettes in cells are prevented effectively; and the selenium content in the bodies of smokers is increased, the resistance to some diseases in human body is increased, and the histopathological, body immune function, body antioxidation function and the like of the body are all improved greatly. The safety cigarettes have the advantages that: the additive has obvious effects in reducing smoke toxicity and improving cigarette product safety; the preparation method of the additive is simple, convenient and practical, and the additive can be widely used by enterprises in cigarette industry.

The present invention provides a therapeutic treatment for a neurodegenerative disease with a pan-PPAR agonist, such as bezafibrate. In particular, the present invention provides that pan-PPAR agonists enhance PPAR related responses in both the central nervous system and peripheral tissues in Huntington's Disease (HD) and tauopathy. Therapeutic compositions comprising one or more pan-PPAR agonist(s), and kit thereof, for treating a neurodegenerative disease or disorder are also provided.

The invention relates to a compound fructus crataegi-turmeric root tuber particle, which is prepared from the following bulk pharmaceuticals in parts by weight: 130-170 parts of fructus crataegi, 60-90 parts of turmeric root tuber, 60-90 parts of oriental waterplantain rhizome, 80-120 parts of seaweed, 60-90 parts of bulb of thunberg fritillary, 80-120 parts of milk thistle and 40-60 parts of peach kernel. The invention further provides a preparation method for the compound fructus crataegi-turmeric root tuber particle. The method comprises the following steps of: weighing fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel according to parts by weight, and adding water for soaking; preparing micro-powder silica gel serving as a single auxiliary material of spray drying and lactose serving as an auxiliary material of particle forming, and standing for later use; adding water in an amount which is 4-10 times that of soaked Chinese medicinal materials including fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel for a first time, adding water in an amount which is 4-10 times that of the Chinese medicinal materials for a second time, and decocting; concentrating an obtained compound extract till the relative density is 1.065, adding an auxiliary material, i.e., micro-powder silica gel, performing spraying drying to obtain extract powder; and adding lactose and ethanol into the extract powder, uniformly mixing, granulating, drying and regulating particles.

Disclosed is a Chinese medicament for treating hypertension which is prepared from the following raw materials: evodia rutaecarpa 10-90g, pinellia tuber 10-40g, hooked uncaria 10-80g, sulfur 10-35g, Loranthus mulberry mistletoe 10-42g, lodestone 10-48g, Ligusticum wallichii 10-90g, chrysanthemum flower 10-80g, wofberry bark 10-65g, kudzuvine root 10-80g, riddle 10-48g, cassia twig 10-26g, malt 10-33g, earthworm 10-80g, alisol 10-65g, rhubarb horsetails 10-65g, sphene 10-45g, soybean 10-90g, eucommia bark 10-80g, trogopterus dung 10-42g, cattail pollen 10-42g, haw 10-50g, areca-nut 10-42g, weeping-willow leaves 10-90g and nifedipine 2-3g.

Methods are for detecting cells over-expressing of Programmed Death Ligand 2 (PD-L2), in particular, damaged and / or senescent cells, and the identification thereof. Antagonists of Programmed Death Ligand 2 (PD-L2) and Programmed Cell Death Protein 1 (PD-1) interaction, or inhibitors of PD-1 or PD-L2 expression are used to eliminate damaged and / or senescent cells, which are involved in numerous pathologies and aging, and are also produced as a result of exposure to toxic substances.

The invention belongs to the technical field of composite materials, and particularly discloses a bio-optical composite material, a preparation method and an application thereof. The bio-optical composite material comprises the following raw materials in parts by weight: 0.5-3 parts of mica, 0.5-2 parts of mirabilite, 0.5-3 parts of haematite, 0.5-1 part of gypsum, 0.5-1 part of magnetite, 0.5-3 parts of cinnabar, 0.5-2 parts of tourmaline, 0.5-3 parts of alum and 0.5-2 parts of medical stone. The raw material fine powder of the bio-optical composite material is evenly mixed in a high-speed mixer, and is irradiated for 12-24 hours by a laser with 457-600nm frequency band and a continuous output power of 400mW. The composite material can convert infrared waves emitted by human bodies to generate short-wave biological waves, can promote cell metabolism, improve cell pathology and improve cell physiology, has the functions of quickly relieving pain, repairing cell damage, dispelling glandhyperplasia, improving cell hypoxia, enhancing muscle fiber strength, strengthening physiological state of human organs and the like, can be used for medical treatment and human body rehabilitation health care, such as preparing multiple medical patches, eyeglass frames and other human body contact articles for daily use.

The invention relates to biological medicine, and discloses application of cowherb seed flavonoid glycoside in preparation of a medicine for treating sepsis, the cowherb seed flavonoid glycoside has the beneficial effects that the cowherb seed flavonoid glycoside is used for preparing the medicine for treating sepsis, the expression and secretion level of cell inflammatory factors can be reduced, and the effect of treating sepsis can be improved. An FKBP5 / NF-kappa B inflammation signal channel of the cell is inhibited; the compound also can reduce the expression levels of inflammatory factors IL-1beta, IL-6 and TNF-alpha and chemotactic factors MCP-1 in serum of animals infected with sepsis, improve the pathology of kidney tissues and lung tissues of the animals infected with sepsis, inhibit the expression of NF-kappa B signaling pathways such as p-P65, NLRP3 and C-caspase-1 in the kidney tissues, reduce the levels of creatinine and urea nitrogen in serum of the kidney tissues, improve pulmonary edema and improve the curative effect of the kidney tissues. The survival rate of animals infected with sepsis is improved, and the kit has a potential treatment effect on sepsis.

The invention discloses traditional Chinese medicine compound hydrogel for skin wound treating and healing. The traditional Chinese medicine compound hydrogel for skin wound treating and healing is prepared from a traditional Chinese medicine composition and a substrate, and is characterized in that the traditional Chinese medicine composition is prepared from the following ingredients in parts byweight: 25 to 35 parts of stir-fried radix scutellariae, 25 to 35 parts of radix codonopsis, 15 to 25 parts of radix angelicae sinensis, 25 to 35 parts of stir-fried bighead atractylodes rhizome, 25to 35 parts of radix paeoniae alba, 25 to 35 parts of poria cocos, 6 to 15 parts of pericarpium citri reticulatae, 10 to 20 parts of frankincense preparata, 10 to 20 parts of myrrh preparata, 15 to 25parts of rhizoma bletillae, 15 to 25 parts of honeysuckle flowers, 15 to 25 parts of rhizoma coptidis and 6 to 15 parts of raw liquorice roots. Compared with the prior art, the traditional Chinese medicine compound hydrogel for skin wound treating and healing has the advantages that the effects of promoting skin wound healing, relieving wound skin tissue pathological conditions of mice, promotingfibroblast chemotaxis and inhibiting inflammation-related transcription factors are achieved; meanwhile, various ingredients are used to achieve synergistic effects; the effects of clearing away heatand toxic materials, eliminating dampness, invigorating qi and blood, nourishing yin, removing stasis and promoting tissue regeneration are achieved; and the efficacies are more.

The invention discloses an application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis. The dosage of the chitosan oligosaccharide which is used is close to that of human bodies, the chitosan oligosaccharide of which the relative molecular weight is 1299 and the deacetylation degree is 85%, is used, and the ulcerative colitis can be intervened. Because the molecular weight of the chitosan oligosaccharide which is used is distributed in a relatively centralized manner, and the mechanism study exerting anti-inflammatory action is clear. Through relieving anemia, improving colon tissue pathology, reducing myeloperoxidase, reducing expression of pro-inflammatory factors in serum, promoting generation of anti-inflammation factors, and influencing the content of short chain fatty acid in intestines, the anti-inflammatory action is further exerted.

The invention discloses ointment for treating chronic atrophic gastritis precancerous lesion. The ointment is prepared from, by weight, 28-32g of Mongolian milkvetch roots, 16-20g of barbed skullcap herb, 28-32g of jobstears seeds, 5-8g of vinegar common burreed rhizomes, 8-10g of dahurian angelica roots, 5-8 parts of galanga resurrectionlily rhizomes, 5-8 parts of appendiculate cremastra pseudobulb, 10-15g of integripetal rhodiola herb, 2-4g of cassiabarktree barks and 2-4g of borneol. When the ointment is used for treating the chronic atrophic gastritis precancerous lesion, the ointment is applied on a Zhongwan point, a Zusanli point, a Pishu point and a Weishu point by the aid of a point application therapy method, gastric mucosal lesion and pathology of patients can be obviously improved, the ointment can effectively improve the symptoms such as gastric cavity pain, gastric cavity distention and fullness, anorexia and debilitation, gastric upset and eructation, the living quality of the patients is improved, the treatment effect of the ointment is obviously superior to that of that of Qilian shupi Granule and Weifuchun, and a statistic difference exists (P<0.05).

The invention provides an application of lonicerin in treating respiratory injury caused by atmospheric particulates and a drug prepared from the lonicerin. The drug comprises the lonicerin and a medicinal carrier, wherein the content of the lonicerin in the drug is 60 mg-100 mg / g, the dosage form of the drug is any one of pharmaceutically acceptable dosage forms including tablets, capsules, oral liquids, buccal tablets, granules, pills, powder, sublimed preparation, suspension concentrate, injections and the like. The respiratory injury symptoms include chest distress, cough, expectoration, wheeze and the like. The blank for research of intervention of the lonicerin in harm of the atmospheric particles to human health is filled up, the real drug effect of the lonicerin for intervention of respiratory inflammation is obtained, and the lonicerin also has good effect on diseases of the whole body system.

Methods and agents for suppressing expression of a mutant allele of a gene and providing a replacement nucleic acid are provided. The methods of the invention provide suppression effectors such as, for example, antisense nucleic acids, ribozymes, or RNAi, that bind to the gene or its RNA. The invention further provides for the introduction of a replacement nucleic acid with modified sequences such that the replacement nucleic acid is protected from suppression by the suppression effector. The replacement nucleic acid is modified at degenerate wobble positions in the target region of the suppression effector and thereby is not suppressed by the suppression effector. In addition, by altering wobble positions, the replacement nucleic acid can still encode a wild type gene product. The invention has the advantage that the same suppression strategy could be used to suppress, in principle, many mutations in a gene. Also disclosed is a transgenic mouse that expresses human rhodopsin (modified replacement gene) and a transgenic mouse that expresses a suppression effector targeting rhodopsin. Also disclosed in intraocular administration of siRNA.

The invention discloses a hypoglycemic application of petroleum ether extract from Derris eriocarpa, having good effect on hyperglycemia of diabetes mellitus in particular. The results showed that theextract could increase the body weight of diabetic mice and decrease the blood glucose of mice, and increase the utilization rate of glucose of HepG2 cells in high glucose model. Experimental research shows that the extract of has better pancreatic protection, improvement of pancreatic pathological degree and hypoglycemic effect on streptozotocin-induced diabetic mice. As such, that present application provide a theoretical basis for further research and development of the Zhuang medicine Derris eriocarpa, so as to provide a novel modern traditional Chinese medicine preparation for treat diabetes by hypoglycemia effect for clinic.

The invention discloses ointment for treating chronic atrophic gastritis precancerous lesion. The ointment is prepared from, by weight, 28-32g of Mongolian milkvetch roots, 16-20g of barbed skullcap herb, 28-32g of jobstears seeds, 5-8g of vinegar common burreed rhizomes, 8-10g of dahurian angelica roots, 5-8 parts of galanga resurrectionlily rhizomes, 5-8 parts of appendiculate cremastra pseudobulb, 10-15g of integripetal rhodiola herb, 2-4g of cassiabarktree barks and 2-4g of borneol. When the ointment is used for treating the chronic atrophic gastritis precancerous lesion, the ointment is applied on a Zhongwan point, a Zusanli point, a Pishu point and a Weishu point by the aid of a point application therapy method, gastric mucosal lesion and pathology of patients can be obviously improved, the ointment can effectively improve the symptoms such as gastric cavity pain, gastric cavity distention and fullness, anorexia and debilitation, gastric upset and eructation, the living quality of the patients is improved, the treatment effect of the ointment is obviously superior to that of that of Qilian shupi Granule and Weifuchun, and a statistic difference exists (P<0.05).

The invention relates to the use of a gastrodia elata active ingredient composition in the preparation of medicines for preventing and treating dementia. The composition is composed of anti-dementia active ingredients I, II and III in the traditional Chinese medicine Gastrodia elata. The anti-dementia effect can be used to prepare medicines or health care products for preventing and treating dementia.

The invention relates to a pharmaceutical composition for treating ulcerative colitis and application of the pharmaceutical composition. The pharmaceutical composition is prepared from folium sauropi extractive and pharmaceutically available auxiliary materials. A preparation method of the folium sauropi extractive comprises the following steps: weighing a folium sauropi raw material, removing impurities, grinding, adding water for soaking, carrying out heating reflux extraction, concentrating an extraction solution and then extracting by using ethyl acetate, recycling the ethyl acetate by using the prepared extraction solution, freezing and drying to obtain the folium sauropi extractive. The extractive is remarkable in treatment effect on ulcerative colitis.

The invention discloses the use of methallyl trisulfide in the preparation of medicines for treating acute lung injury. And a methallyl trisulfide is used as an active ingredient of a drug for treating acute lung injury in preparations and compound preparations. The experimental results showed that compared with the blank control group, the ratio of lung wet weight to body weight in the model group increased, the pathological damage was obvious, and the protein content, cell number and pro-inflammatory factor levels in BALF increased, and the difference was statistically significant (P<0.05 ), indicating that the model is established.

The invention relates to a composition for relieving and treating acne and application thereof. The composition is prepared from the following raw materials in parts by weight: 5-15 parts of paris polyphylla, 20-40 parts of flos chrysanthemi indici, 20-40 parts of hairy euphorbia and 5-15 parts of radix angelicae. In the formula, the paris polyphylla is used as a monarch drug for clearing away heat and toxic materials and relieving swelling and pain; the wild chrysanthemum is used as a ministerial drug for enhancing the heat-clearing and detoxifying effects of the paris polyphylla; the radix angelicae is used as an adjuvant drug for relieving pain and swelling, and the haworthia chrysantha is used as a conductant drug for assisting the main drug for relieving swelling and toxic materials; and the four drugs are combined to achieve the effects of clearing away heat and toxic materials and relieving swelling and pain. The invention is proper in formula, the rabbit ear acne model experiment and the propionibacterium acnes in-vitro inhibition experiment research prove that the apparent symptom and the pathology of the acne animal model can be significantly improved, the growth of the propionibacterium acnes can be significantly inhibited, and the effect is prominent. Therefore, the acnes can be applied to the research of acne-removing products in the fields of clinical acne treatment medicines or cosmetics.

The invention discloses the application of a prolyl hydroxylase inhibitor in the preparation of a drug for improving the symptoms of hepatolenticular degeneration disease. The prolyl hydroxylase inhibitor used in the invention can stabilize HIF‑1α and activate it. Transcriptional activity; the gray scale of the liver was weakened, and the expression of lipid metabolism factors was significantly reduced. H&E staining of the liver showed that prolyl hydroxylase inhibitors can effectively improve liver pathology and reduce liver copper accumulation; Expression of neuronal signaling and factors related to dopaminergic neuronal signaling was improved, and motor performance was improved.

The invention relates to a pharmaceutical composition for treating chronic nephritis, which is composed of effective pharmaceutical ingredients and auxiliary materials. The pharmaceutical composition can significantly improve the renal histopathology of patients and reduce the amount of 24-hour urine protein of patients. More specifically, the drug of the present invention can effectively promote the expression and activity of Ak phosphorylation, thereby promoting the anti-apoptotic effect of the p-Akt signaling pathway, and finally exerting the therapeutic effect on chronic nephritis. The present invention also provides the application of the active pharmaceutical ingredient in the preparation of a pharmaceutical composition for treating chronic nephritis.

The invention discloses an application of methyl allyl trisulfide in preparation of a medicine for treating acute lung injury. The invention further discloses application of the methyl allyl trisulfide serving as a medicine active ingredient for treating acute lung injury in preparations and compound preparations. Experimental results show that compared with a blank control group, the lung-damp weight ratio of a model group is increased, pathological damage is obvious, the protein content, the cell number and the proinflammatory factor level in BALF are increased, the difference has statistical significance (P is smaller than 0.05), and it is indicated that the model is established.

The invention discloses an application of a Nitraria fruit chloroform extract, particularly relates to an application of the Nitraria fruit chloroform extract in the preparation of drugs for preventing / treating colitis diseases. Experiments prove that the Nitraria fruit chloroform extract has significant effects on mice with DSS-induced ulcerative colitis by means of intragastric administration. The effects comprise effectively improving the general state of the mice with ulcerative colitis, significantly inhibiting DSS-induced mouse colon shortening, improving colonic histopathology, reducingmyeloperoxidase, significantly reducing inflammation, reducing the expression of pro-inflammatory factors in serum, promoting the production of inflammation suppression factors, and thereby playing anti-inflammatory effects. The Nitraria fruit chloroform extract has application prospects in treating ulcerative colitis diseases.

Disclosed is a Chinese medicament for treating hypertension which is prepared from the following raw materials: evodia rutaecarpa 10-90g, pinellia tuber 10-40g, hooked uncaria 10-80g, sulfur 10-35g, Loranthus mulberry mistletoe 10-42g, lodestone 10-48g, Ligusticum wallichii 10-90g, chrysanthemum flower 10-80g, wofberry bark 10-65g, kudzuvine root 10-80g, riddle 10-48g, cassia twig 10-26g, malt 10-33g, earthworm 10-80g, alisol 10-65g, rhubarb horsetails 10-65g, sphene 10-45g, soybean 10-90g, eucommia bark 10-80g, trogopterus dung 10-42g, cattail pollen 10-42g, haw 10-50g, areca-nut 10-42g, weeping-willow leaves 10-90g and nifedipine 2-3g.

The invention discloses a mycobecterium tuberculosis vaccine series medicaments and its use, wherein the series medicaments consist of matched mycobacterium tuberculosis vaccine and Calmette, the mycobacterium tuberculosis vaccine being nucleic acid sequences obtained through subjecting Ag85B, MPT-83 and MPT-64 to fusion or deletion of partial sequence or partial mutation with other nucleic acidscapable of encoding nucleic acid sequences having the same reactive protein as Ag85B, MPT-83 and MPT-64, they are cloned into eucaryon expressed carrying agent, thus obtaining at least two of the prepared expression carriers for combination.