39results about How to "Improve pathology" patented technology

The invention discloses a traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis. Active pharmaceutical ingredients of the traditional Chinese medicine composition comprise, by weight, 10-15 parts of the root of red-rooted salvia, 10-60 parts of astragalus membranaceus, 10-30 parts of herba epimedii, 5-30 parts of sinensis and 3-30 parts of prepared rhubarb. Clinical researches show that 168 patients with chronic renal insufficiency are treated by the traditional Chinese medicine composition, a remarkable clinical effect is obtained, clinical symptoms are reduced, the clinical symptoms of some patients are basically eliminated, the renal functions of the patients can be remarkably improved, blood urea nitrogen (BUN) and creatinine (Scr) are obviously reduced, and total effective rate achieves 88.66%. Animal researches show that the traditional Chinese medicine composition can delay development of chronic renal failure, and the mechanism of the traditional Chinese medicine composition is relative to effects of effectively restraining precipitation of renal tissue collagen and secretion of TGF (transforming growth factor)-beta, accordingly restraining renal fibrosis, and the like. The traditional Chinese medicine composition is low in clinical application cost and excellent in curative effect, and is safe and reliable.

The present invention provides a therapeutic treatment for a neurodegenerative disease with a pan-PPAR agonist, such as bezafibrate. In particular, the present invention provides that pan-PPAR agonists enhance PPAR related responses in both the central nervous system and peripheral tissues in Huntington's Disease (HD) and tauopathy. Therapeutic compositions comprising one or more pan-PPAR agonist(s), and kit thereof, for treating a neurodegenerative disease or disorder are also provided.

The invention relates to a compound fructus crataegi-turmeric root tuber particle, which is prepared from the following bulk pharmaceuticals in parts by weight: 130-170 parts of fructus crataegi, 60-90 parts of turmeric root tuber, 60-90 parts of oriental waterplantain rhizome, 80-120 parts of seaweed, 60-90 parts of bulb of thunberg fritillary, 80-120 parts of milk thistle and 40-60 parts of peach kernel. The invention further provides a preparation method for the compound fructus crataegi-turmeric root tuber particle. The method comprises the following steps of: weighing fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel according to parts by weight, and adding water for soaking; preparing micro-powder silica gel serving as a single auxiliary material of spray drying and lactose serving as an auxiliary material of particle forming, and standing for later use; adding water in an amount which is 4-10 times that of soaked Chinese medicinal materials including fructus crataegi, turmeric root tuber, oriental waterplantain rhizome, seaweed, bulb of thunberg fritillary, milk thistle and peach kernel for a first time, adding water in an amount which is 4-10 times that of the Chinese medicinal materials for a second time, and decocting; concentrating an obtained compound extract till the relative density is 1.065, adding an auxiliary material, i.e., micro-powder silica gel, performing spraying drying to obtain extract powder; and adding lactose and ethanol into the extract powder, uniformly mixing, granulating, drying and regulating particles.

The invention discloses ointment for treating chronic atrophic gastritis precancerous lesion. The ointment is prepared from, by weight, 28-32g of Mongolian milkvetch roots, 16-20g of barbed skullcap herb, 28-32g of jobstears seeds, 5-8g of vinegar common burreed rhizomes, 8-10g of dahurian angelica roots, 5-8 parts of galanga resurrectionlily rhizomes, 5-8 parts of appendiculate cremastra pseudobulb, 10-15g of integripetal rhodiola herb, 2-4g of cassiabarktree barks and 2-4g of borneol. When the ointment is used for treating the chronic atrophic gastritis precancerous lesion, the ointment is applied on a Zhongwan point, a Zusanli point, a Pishu point and a Weishu point by the aid of a point application therapy method, gastric mucosal lesion and pathology of patients can be obviously improved, the ointment can effectively improve the symptoms such as gastric cavity pain, gastric cavity distention and fullness, anorexia and debilitation, gastric upset and eructation, the living quality of the patients is improved, the treatment effect of the ointment is obviously superior to that of that of Qilian shupi Granule and Weifuchun, and a statistic difference exists (P<0.05).

The invention provides an application of lonicerin in treating respiratory injury caused by atmospheric particulates and a drug prepared from the lonicerin. The drug comprises the lonicerin and a medicinal carrier, wherein the content of the lonicerin in the drug is 60 mg-100 mg / g, the dosage form of the drug is any one of pharmaceutically acceptable dosage forms including tablets, capsules, oral liquids, buccal tablets, granules, pills, powder, sublimed preparation, suspension concentrate, injections and the like. The respiratory injury symptoms include chest distress, cough, expectoration, wheeze and the like. The blank for research of intervention of the lonicerin in harm of the atmospheric particles to human health is filled up, the real drug effect of the lonicerin for intervention of respiratory inflammation is obtained, and the lonicerin also has good effect on diseases of the whole body system.

The invention discloses ointment for treating chronic atrophic gastritis precancerous lesion. The ointment is prepared from, by weight, 28-32g of Mongolian milkvetch roots, 16-20g of barbed skullcap herb, 28-32g of jobstears seeds, 5-8g of vinegar common burreed rhizomes, 8-10g of dahurian angelica roots, 5-8 parts of galanga resurrectionlily rhizomes, 5-8 parts of appendiculate cremastra pseudobulb, 10-15g of integripetal rhodiola herb, 2-4g of cassiabarktree barks and 2-4g of borneol. When the ointment is used for treating the chronic atrophic gastritis precancerous lesion, the ointment is applied on a Zhongwan point, a Zusanli point, a Pishu point and a Weishu point by the aid of a point application therapy method, gastric mucosal lesion and pathology of patients can be obviously improved, the ointment can effectively improve the symptoms such as gastric cavity pain, gastric cavity distention and fullness, anorexia and debilitation, gastric upset and eructation, the living quality of the patients is improved, the treatment effect of the ointment is obviously superior to that of that of Qilian shupi Granule and Weifuchun, and a statistic difference exists (P<0.05).

The invention relates to the use of a gastrodia elata active ingredient composition in the preparation of medicines for preventing and treating dementia. The composition is composed of anti-dementia active ingredients I, II and III in the traditional Chinese medicine Gastrodia elata. The anti-dementia effect can be used to prepare medicines or health care products for preventing and treating dementia.

The invention discloses the use of methallyl trisulfide in the preparation of medicines for treating acute lung injury. And a methallyl trisulfide is used as an active ingredient of a drug for treating acute lung injury in preparations and compound preparations. The experimental results showed that compared with the blank control group, the ratio of lung wet weight to body weight in the model group increased, the pathological damage was obvious, and the protein content, cell number and pro-inflammatory factor levels in BALF increased, and the difference was statistically significant (P<0.05 ), indicating that the model is established.

The invention relates to a composition for relieving and treating acne and application thereof. The composition is prepared from the following raw materials in parts by weight: 5-15 parts of paris polyphylla, 20-40 parts of flos chrysanthemi indici, 20-40 parts of hairy euphorbia and 5-15 parts of radix angelicae. In the formula, the paris polyphylla is used as a monarch drug for clearing away heat and toxic materials and relieving swelling and pain; the wild chrysanthemum is used as a ministerial drug for enhancing the heat-clearing and detoxifying effects of the paris polyphylla; the radix angelicae is used as an adjuvant drug for relieving pain and swelling, and the haworthia chrysantha is used as a conductant drug for assisting the main drug for relieving swelling and toxic materials; and the four drugs are combined to achieve the effects of clearing away heat and toxic materials and relieving swelling and pain. The invention is proper in formula, the rabbit ear acne model experiment and the propionibacterium acnes in-vitro inhibition experiment research prove that the apparent symptom and the pathology of the acne animal model can be significantly improved, the growth of the propionibacterium acnes can be significantly inhibited, and the effect is prominent. Therefore, the acnes can be applied to the research of acne-removing products in the fields of clinical acne treatment medicines or cosmetics.

The invention discloses the application of a prolyl hydroxylase inhibitor in the preparation of a drug for improving the symptoms of hepatolenticular degeneration disease. The prolyl hydroxylase inhibitor used in the invention can stabilize HIF‑1α and activate it. Transcriptional activity; the gray scale of the liver was weakened, and the expression of lipid metabolism factors was significantly reduced. H&E staining of the liver showed that prolyl hydroxylase inhibitors can effectively improve liver pathology and reduce liver copper accumulation; Expression of neuronal signaling and factors related to dopaminergic neuronal signaling was improved, and motor performance was improved.

The present invention provides a therapeutic treatment for a neurodegenerative disease with a pan-PPAR agonist, such as bezafibrate. In particular, the present invention provides that pan-PPAR agonists enhance PPAR related responses in both the central nervous system and peripheral tissues in Huntington's Disease (HD) and tauopathy. Therapeutic compositions comprising one or more pan-PPAR agonist(s), and kit thereof, for treating a neurodegenerative disease or disorder are also provided.

Disclosed is a Chinese medicament for treating hypertension which is prepared from the following raw materials: evodia rutaecarpa 10-90g, pinellia tuber 10-40g, hooked uncaria 10-80g, sulfur 10-35g, Loranthus mulberry mistletoe 10-42g, lodestone 10-48g, Ligusticum wallichii 10-90g, chrysanthemum flower 10-80g, wofberry bark 10-65g, kudzuvine root 10-80g, riddle 10-48g, cassia twig 10-26g, malt 10-33g, earthworm 10-80g, alisol 10-65g, rhubarb horsetails 10-65g, sphene 10-45g, soybean 10-90g, eucommia bark 10-80g, trogopterus dung 10-42g, cattail pollen 10-42g, haw 10-50g, areca-nut 10-42g, weeping-willow leaves 10-90g and nifedipine 2-3g.

The invention discloses a traditional Chinese medicine for treating atrophic gastritis and precancerous lesions thereof, relating to the technical field of traditional Chinese medicines. The traditional Chinese medicine contains the following raw materials in parts by weight: 10-20 parts of lizards, 10-30 parts of radix pseudostellariae, 10-50 parts of radix astragali, 10-20 parts of dendrobe, 10-20 parts of coaled dark plum, 10-20 parts of radix paeoniae alba, 10-30 parts of herba scutellariae barbatae, 10-30 parts of mock strawberries, 3-6 parts of pseudo-ginseng, 10-20 parts of fructus aurantii and 6-10 parts of liquorice. The traditional Chinese medicine has the efficacies of benefiting vital energy, nourishing yin, relieving internal heat or fever, dredging collaterals, regulating vital energy and alleviating pain, is capable of effectively improving clinical symptoms and gastric mucosa pathology of patients with atrophic gastritis and has relatively good effects on the promotionof mucosal recovery and the interdiction of canceration.

The invention discloses a mycobecterium tuberculosis vaccine series medicaments and its use, wherein the series medicaments consist of matched mycobacterium tuberculosis vaccine and Calmette, the mycobacterium tuberculosis vaccine being nucleic acid sequences obtained through subjecting Ag85B, MPT-83 and MPT-64 to fusion or deletion of partial sequence or partial mutation with other nucleic acidscapable of encoding nucleic acid sequences having the same reactive protein as Ag85B, MPT-83 and MPT-64, they are cloned into eucaryon expressed carrying agent, thus obtaining at least two of the prepared expression carriers for combination.