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Pharmaceutical composition for treating chronic nephritis

A technology of chronic nephritis and composition, applied in the field of medicine, can solve problems such as poor prognosis

Inactive Publication Date: 2017-09-19
魏芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there are main symptoms such as edema, proteinuria, and hematuria. If timely and effective treatment cannot be obtained, most patients will turn into chronic renal insufficiency, and the prognosis is poor.

Method used

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  • Pharmaceutical composition for treating chronic nephritis
  • Pharmaceutical composition for treating chronic nephritis
  • Pharmaceutical composition for treating chronic nephritis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] The characterization of experimental example 1 medicine of the present invention

[0023]

[0024] 1 H NMR (400MHz, CDCl 3 )δ8.14(d, J=2.4Hz, 1H), 7.7(dd, J=8.4, 2.4Hz, 1H), 7.70(d, J=8.4Hz, 1H), 7.64(d, J=2.4Hz, 1H), 7.23-7.16(m, 2H), 5.17(s, 2H), 2.92(t, J=6.4Hz, 2H), 2.65(dd, J=13.2, 6.0Hz, 2H), 2.60(s, 3H ),2.16-2.10(m,2H).

experiment example 2

[0025] Experimental example 2 the effect of medicine treatment chronic nephritis of the present invention

[0026] Animals and Groups

[0027] Select healthy and clean male SD rats with a body weight of 120-150 g, and feed them with an adaptive common diet at room temperature for 1 week. The rats are divided into blank group, model group, and high, medium and low dose groups of the drug of the present invention by random number table method , 10 each. The urine protein was qualitatively negative for 2 times (test strip method) and then the model was established. Rats were sacrificed at the end of the 16th week.

[0028] modeling

[0029] Reference literature (Zhang Xiaoqiang, Liu Pinli, Li Mengfang, et al. Development of animal models of allergic purpura epilepsy. Chinese Journal of Traditional Chinese Medicine, 2011, 26(10): 2319-2324.): Model group and the drug of the present invention have high, medium and low The dose group used the BSA+SFB method to create the IgA nep...

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Abstract

The invention relates to a pharmaceutical composition for treating chronic nephritis, which is composed of effective pharmaceutical ingredients and auxiliary materials. The pharmaceutical composition can significantly improve the renal histopathology of patients and reduce the amount of 24-hour urine protein of patients. More specifically, the drug of the present invention can effectively promote the expression and activity of Ak phosphorylation, thereby promoting the anti-apoptotic effect of the p-Akt signaling pathway, and finally exerting the therapeutic effect on chronic nephritis. The present invention also provides the application of the active pharmaceutical ingredient in the preparation of a pharmaceutical composition for treating chronic nephritis.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating chronic nephritis. Background technique [0002] Chronic glomerulonephritis (chronic nephritis) is a common clinical difficult disease, which is composed of many reasons and various pathological types. , Many have a history of acute nephritis. The clinical feature is that the course of the disease is long, there may be a period of asymptomatic period, and the course of the disease is slowly progressive. Chronic nephritis is a common disease, frequently-occurring disease, long course of disease, and difficult to treat. According to relevant literature reports, patients with chronic renal failure account for about 1 / 10,000 in my country. Among the various causes of end-stage chronic renal failure, chronic renal failure Nephritis takes the first place, accounting for about 64.1%. Clinically, there are main symptoms such as ed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P13/12
CPCA61K31/122
Inventor 魏芳
Owner 魏芳
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