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Use of physically modified Chinese cobra snake venom in the preparation of medicines for treating acute and chronic kidney diseases

A technology of Chinese cobra and cobra snake venom, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of large side effects, easy recurrence, difficult to cure, etc., and achieve low toxicity, large effective range, and medicine. Efficient effect

Active Publication Date: 2015-11-18
SUZHOU RENBEN PHARMA
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  • Description
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Problems solved by technology

Nephrotic syndrome is a relatively difficult disease to cure clinically, and proteinuria is the main diagnostic index clinically. At present, the drug treatment for nephrotic syndrome is still based on prednisone and other glucocorticoids, but long-term application of side effects large and prone to recurrence

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  • Use of physically modified Chinese cobra snake venom in the preparation of medicines for treating acute and chronic kidney diseases
  • Use of physically modified Chinese cobra snake venom in the preparation of medicines for treating acute and chronic kidney diseases
  • Use of physically modified Chinese cobra snake venom in the preparation of medicines for treating acute and chronic kidney diseases

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Embodiment Construction

[0046] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions adopted in the examples can be further adjusted according to the conditions of specific experiments, and the implementation conditions not indicated are usually the conditions in routine experiments.

[0047] The animal pharmacodynamics experiment of the Chinese cobra snake venom after embodiment physical treatment

[0048] (1) Acute kidney disease experiment in rats induced by glycerol

[0049] In this experiment, after the rats were deprived of water for 24 hours, 50% glycerol was injected intramuscularly into both sides of the buttocks according to the weight of the rats at 8ml / kg to reproduce the acute kidney disease model. The Wistar rats were randomly divided into 5 groups: normal saline control group a...

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Abstract

The invention discloses an application of physically-modified Chinese cobra venom in preparation of medicaments for treating acute and chronic nephrosis. The physically-modified Chinese cobra venom is obtained by dissolving Chinese cobra venom with deionized water, heating for denaturation and then performing renaturation; the heating temperature is controlled to be 50-100 DEG C, and the heating time is controlled to be 1 min-300 min. The invention finds that the heated and denaturated Chinese cobra venom can effectively reduce urine protein in acute and chronic nephrosis, reduce serum creatinine, and urea nitrogen, improve the pathological damage degree of the kidney, and recover kidney functions.

Description

technical field [0001] The invention relates to the use of physically modified Chinese cobra venom in the preparation of medicines for treating acute and chronic kidney diseases. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. Snake venom is a complex mixture of components secreted by the snake's venom glands. Fresh venom is egg white-like viscous liquid with a special fishy smell. The venom of different snake species has different colors, and the venom of the Chinese cobra is light yellow. More than 90% of the dry matter of snake venom is protein, which is the main component of its toxicity and biological activity. The components of Chinese cobra venom mainly include cobra venom factor (1%-2%), cardiotoxin (40%-50%, also known as cytotoxin, membrane toxin), neurotoxin (10%) and other proteins. The traditional medicine of the motherland believes that cobra and its toxic components can clear the meridians,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/583A61P13/12
Inventor 秦正红王姝之何鹤
Owner SUZHOU RENBEN PHARMA
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