Application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis
A technology of ulcerative colitis and functional food, applied in the field of functional food, can solve problems such as recurrence of the disease, increased financial burden on patients, and increased side effects
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Embodiment 1
[0050] Example 1: Narrowly distributed chitosan oligosaccharides on the body weight and DAI index of colitis mice induced by DSS
[0051] The mice were weighed every day of feeding, and the degree of body weight change from the first day was calculated. Observe the status of feces and detect occult blood, calculate the disease activity index DAI value, refer to figure 1 It can be seen that the oligochitosaccharides of the present invention can significantly improve the weight loss, loose and moist stool and occult blood in the colitis mice induced by DSS on the 3rd day after gavage, and the DAI index is significantly reduced (P<0.01).
Embodiment 2
[0052]Embodiment 2: Narrowly distributed chitosan oligosaccharides on the impact of DSS-induced colitis mice spleen index and blood indicators
[0053] The organ index refers to the percentage of organs in body weight. Such as figure 2 As shown, free drinking of 3% DSS for 7 days caused the spleen and kidney to account for a very significant increase in the body weight of the mice compared with the control group (P 0.05).
Embodiment 3
[0054] Example 3: Narrowly distributed chitosan oligosaccharides on the impact of DSS-induced colitis mice colon length and MPO
[0055] refer to image 3 It can be seen that compared with the normal group, the colon length of the mice with ulcerative colitis was significantly shortened compared with the control group, and the severity of inflammation was roughly proportional to the degree of shortening of the colon. The colonic mucosa was congested in a large area, with unclear borders, swelling visible to the naked eye, and mucosal swelling after longitudinal incision. The thickness of the intestinal wall varied, and some intestinal lumens were narrowed. There were also multiple erosions and scattered ulcers. Compared with the model group, the length of the colon of the mice in the chitosan oligosaccharide group was significantly increased (P<0.05), the inner cavity was smoother, and the ulcers were also significantly reduced. MPO is a characteristic enzyme of neutrophils, ...
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