Application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis

A technology of ulcerative colitis and functional food, applied in the field of functional food, can solve problems such as recurrence of the disease, increased financial burden on patients, and increased side effects

Pending Publication Date: 2020-02-07
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the long-term application of commonly used drugs for clinical UC treatment, such as aminosalicylic acid preparations, hormones, and immunosuppressants, can easily cause an increase in obvious side effects, and it is easy to cause disease recurrence after drug withdrawal, which aggravates the psychological burden of patients, and the curative effect is not satisfactory. people are satisfied
However, biological agents are still expensive, which increases the economic burden of patients and greatly affects their clinical promotion.
[0003] Chitosan oligosaccharides are obtained by chemical or enzymatic hydrolysis of chitosan. Studies have found that chitosan oligosaccharides have various activities such as anti-tumor, lowering cholesterol, and lowering blood pressure. They are used as antioxidants and antibacterial agents in food. Chitosan oligosaccharides There is a close relationship between the molecular weight of chitosan and the effect of application technology, but the application and mechanism of action of chitosan oligosaccharides in the preparation of functional foods for intervention in ulcerative colitis have not been reported, which affects its further application

Method used

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  • Application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis
  • Application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis
  • Application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1: Narrowly distributed chitosan oligosaccharides on the body weight and DAI index of colitis mice induced by DSS

[0051] The mice were weighed every day of feeding, and the degree of body weight change from the first day was calculated. Observe the status of feces and detect occult blood, calculate the disease activity index DAI value, refer to figure 1 It can be seen that the oligochitosaccharides of the present invention can significantly improve the weight loss, loose and moist stool and occult blood in the colitis mice induced by DSS on the 3rd day after gavage, and the DAI index is significantly reduced (P<0.01).

Embodiment 2

[0052]Embodiment 2: Narrowly distributed chitosan oligosaccharides on the impact of DSS-induced colitis mice spleen index and blood indicators

[0053] The organ index refers to the percentage of organs in body weight. Such as figure 2 As shown, free drinking of 3% DSS for 7 days caused the spleen and kidney to account for a very significant increase in the body weight of the mice compared with the control group (P 0.05).

Embodiment 3

[0054] Example 3: Narrowly distributed chitosan oligosaccharides on the impact of DSS-induced colitis mice colon length and MPO

[0055] refer to image 3 It can be seen that compared with the normal group, the colon length of the mice with ulcerative colitis was significantly shortened compared with the control group, and the severity of inflammation was roughly proportional to the degree of shortening of the colon. The colonic mucosa was congested in a large area, with unclear borders, swelling visible to the naked eye, and mucosal swelling after longitudinal incision. The thickness of the intestinal wall varied, and some intestinal lumens were narrowed. There were also multiple erosions and scattered ulcers. Compared with the model group, the length of the colon of the mice in the chitosan oligosaccharide group was significantly increased (P<0.05), the inner cavity was smoother, and the ulcers were also significantly reduced. MPO is a characteristic enzyme of neutrophils, ...

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PUM

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Abstract

The invention discloses an application of chitosan oligosaccharide to preparation of functional foods for intervening ulcerative colitis. The dosage of the chitosan oligosaccharide which is used is close to that of human bodies, the chitosan oligosaccharide of which the relative molecular weight is 1299 and the deacetylation degree is 85%, is used, and the ulcerative colitis can be intervened. Because the molecular weight of the chitosan oligosaccharide which is used is distributed in a relatively centralized manner, and the mechanism study exerting anti-inflammatory action is clear. Through relieving anemia, improving colon tissue pathology, reducing myeloperoxidase, reducing expression of pro-inflammatory factors in serum, promoting generation of anti-inflammation factors, and influencing the content of short chain fatty acid in intestines, the anti-inflammatory action is further exerted.

Description

technical field [0001] The invention relates to the application of chitosan oligosaccharide in the preparation of functional food for intervening ulcerative colitis, belonging to the technical field of functional food. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a chronic non-specific inflammatory disease that predominates in the colorectum. Genetics, environment, immunity, and intestinal flora all mediate the occurrence of the disease. At present, there is no definitive cure. The purpose of clinical medication is to induce and maintain clinical remission and mucosal healing, prevent complications, and improve the quality of life of patients. However, the long-term application of commonly used drugs for clinical UC treatment, such as aminosalicylic acid preparations, hormones, and immunosuppressants, can easily cause an increase in obvious side effects, and it is easy to cause disease recurrence after drug withdrawal, which aggravates the psy...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61P1/00A61P1/04A61P7/06A61P29/00A23L29/30A23L33/125
CPCA61K31/722A61P1/00A61P1/04A61P7/06A61P29/00A23L29/30A23L33/125A23V2002/00
Inventor 夏文水王斌陈爽姜启兴许艳顺刘晓丽于沛沛
Owner JIANGNAN UNIV
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