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A technology of extract and white thorn fruit, applied in the field of medicine
Pending Publication Date: 2020-07-28
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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[0023] The described Nitraria chloroform extract is prepared through the following preparation method, including pretreatment, extraction, extraction and posttreatment steps, specifically including:
[0024] A, pre-treatment: dry, pulverize and sieve the fruit part of the dried Nitraria plant to obtain material a; add petroleum ether 3 to 5 times the quality of material a to material a, degrease and depigment to obtain material b;
[0025] B. Extraction: adding 92-97% ethanol solution by volume percentage to the material b to reflux extraction for 2-4 times, combining the extracts, concentrating under reduced pressure to obtain extract c;
[0026] C. Extraction: add 2 to 3 times the volume of extract c to the extract c to suspend and disperse to obtain material d, which is extracted 2 to 4 times with equal volumes of chloroform, ethyl acetate and n-butanol, and recovered Solvent to obtain chloroform extract f, ethyl acetate extract g, n-butanol extract h and aqueous phase part...
Embodiment 1
[0035] Preparation of Nitraria chloroform extract:
[0036] (1) Dried the fruit part of the dried Nitraria plant and crushed it into powder, took 500g of freeze-dried and crushed Nitraria, first degreased and depigmented with petroleum ether, and then heated and refluxed with 95% ethanol to extract 3 times ( The extraction temperature is 80°C, the ratio of solid to liquid is 1:5, and the extraction time is 2h, 1.5h, and 1h respectively), the extracts are combined and concentrated under reduced pressure to obtain the extract.
[0037] (2) Suspend and disperse the extract prepared in (1) with water, extract three times with equal volumes of chloroform, ethyl acetate and n-butanol respectively, recover the solvent, and obtain chloroform extract, ethyl acetate extract, n-butanol extract and aqueous fraction.
[0038] (3) The chloroform extract obtained in (2) was concentrated under reduced pressure for subsequent experiments.
Embodiment 2
[0040] Observation on the efficacy of chloroform extract of Nitraria japonica on UC mouse model
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Abstract
The invention discloses an application of a Nitraria fruit chloroform extract, particularly relates to an application of the Nitraria fruit chloroform extract in the preparation of drugs for preventing/treating colitis diseases. Experiments prove that the Nitraria fruit chloroform extract has significant effects on mice with DSS-induced ulcerative colitis by means of intragastric administration. The effects comprise effectively improving the general state of the mice with ulcerative colitis, significantly inhibiting DSS-induced mouse colon shortening, improving colonic histopathology, reducingmyeloperoxidase, significantly reducing inflammation, reducing the expression of pro-inflammatory factors in serum, promoting the production of inflammation suppression factors, and thereby playing anti-inflammatory effects. The Nitraria fruit chloroform extract has application prospects in treating ulcerative colitis diseases.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a chloroform extract of Nitraria japonica. Background technique [0002] Ulcerative colitis (UC) is a major type of inflammatory bowel disease (inflammatory bowel disease, IBD). It can recur. In recent years, the incidence of inflammatory bowel disease has shown a trend of global spread, showing that the incidence rate in many regions is increasing, especially in Asia, the Middle East and South America. Its clinical manifestations are abdominal pain, diarrhea, mucus and bloody stools, etc., limited to the colonic mucosa and submucosa. The disease has a long course and often recurs. At present, there is no definite cause of the disease, and there is still no specific drug for the treatment of UC, so it is listed by the World Health Organization as one of the modern intractable diseases. [0003] The pathogenic factors and pathogenesis of UC are no...
Claims
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