Application of methyl allyl trisulfide in preparation of medicine for treating acute lung injury
A technology of methallyl trisulfide and acute lung injury, which is applied in the field of medicine and can solve the problems of no specific prevention and treatment drugs for ALI
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Embodiment 1
[0028] Chemical Reagents and Instruments
[0029] AMTS (CAS No.: 34135-85-8) was purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd., LPS was purchased from Sigma, BCA kit was purchased from Thermo Fisher Scientific, TNF-α, IL-1β kits were purchased from Corn oil was purchased from the market from Wuhan Cloud Clone Technology Co., Ltd. Desktop refrigerated centrifuge Eppendorf (5804R), pipette gun (Eppendorf), Ruiwode R540 enhanced small animal anesthesia machine.
[0030] Animal experiment
[0031] 60 ICR male mice, weighing 18-22 g, were purchased from Jinan Pengyue Experimental Animal Breeding Co., Ltd., and the animals were raised in the IVC Animal Breeding Department, with free access to water and food. After one week of adaptive feeding, they were randomly divided into blank control group, model control group, AMTS low-dose intervention group (25mg / kg.bw), AMTS medium-dose intervention group (50mg / kg.bw), AMTS high-dose intervention group (100mg / kg.bw), 12...
Embodiment 2
[0053] The invention discloses a soft capsule containing methallyl trisulfide for treating acute lung injury. The soft capsule comprises: methallyl trisulfide, auxiliary materials and a soft capsule shell, and is directly packed by a soft capsule filling process. Usage and dosage: oral administration, 2.78~11.1mg / kg.bw, it can be determined according to the actual condition.
Embodiment 3
[0055] Disclosed is a drop pill containing methallyl trisulfide for treating acute lung injury. The drop pill comprises: methallyl trisulfide and a substrate, and is directly prepared into pills through a drop pill process. Usage and dosage: oral administration, 2.78~11.1mg / kg.bw, it can be determined according to the actual condition.
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