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Pharmaceutical composition for treating ulcerative colitis and application thereof

A technique for ulcerative colitis and composition, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2014-09-24
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no literature report that the extract of Longan Leaf has the effect of treating ulcerative colitis

Method used

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  • Pharmaceutical composition for treating ulcerative colitis and application thereof
  • Pharmaceutical composition for treating ulcerative colitis and application thereof
  • Pharmaceutical composition for treating ulcerative colitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 asparagus leaf extract

[0016] Remove impurities from the leaves of asparagus, clean them, crush them to a particle size of about 32 meshes, weigh 10kg of asparagus leaves powder, place them in a reflux extraction device, add 85L of purified water to soak for 1 hour, then heat and reflux for 1 hour of extraction, and extract 2 times in total. Combine the extracts, concentrate under reduced pressure to 1.5 times (v / w) of the weight of the leaves of Asparagus leaves raw materials, add an equal volume of ethyl acetate to extract 3 times, combine the extracts, reclaim the ethyl acetate and freeze-dry it with a lyophilizer, pulverize, Lemongrass Leaf Extract.

Embodiment 2

[0017] The preparation of embodiment 2 asparagus leaf extract

[0018] Remove impurities from the leaves of asparagus, clean them, crush them to a particle size of about 32 mesh, weigh 10kg of asparagus leaf powder, place them in an extraction device, add 100L of purified water to soak for 1 hour, then heat and reflux for extraction for 1.5 hours, and extract twice in total. Combine the extracts, concentrate under reduced pressure to 1 time (v / w) of the weight of the leaves of Asparagus leaf raw materials, add an equal volume of ethyl acetate to extract twice, combine the extracts, reclaim the ethyl acetate and freeze-dry it with a freeze dryer, pulverize, Lemongrass Leaf Extract.

Embodiment 3

[0019] Example 3 Therapeutic Experimental Research of Asparagus Leaf Extract on Ulcerative Colitis Mice

[0020] 40 healthy adult Kunming mice, male, weighing 20-24 g, were randomly divided into the following 4 groups: blank control group, model control group, low-dose drug group, and high-dose drug group. The blank control group drank distilled water freely, and the rest of the groups drank 5% dextran sodium sulfate aqueous solution freely for 6 days to create a mouse colitis model. During the modeling period, the blank control group and the model control group were intragastrically administered normal saline every day; the drug low and high dose groups were intragastrically administered 50, 150 mg / kg Longania leaf extract (prepared in Example 1 of the present invention) every day.

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Abstract

The invention relates to a pharmaceutical composition for treating ulcerative colitis and application of the pharmaceutical composition. The pharmaceutical composition is prepared from folium sauropi extractive and pharmaceutically available auxiliary materials. A preparation method of the folium sauropi extractive comprises the following steps: weighing a folium sauropi raw material, removing impurities, grinding, adding water for soaking, carrying out heating reflux extraction, concentrating an extraction solution and then extracting by using ethyl acetate, recycling the ethyl acetate by using the prepared extraction solution, freezing and drying to obtain the folium sauropi extractive. The extractive is remarkable in treatment effect on ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating ulcerative colitis and its application. Background technique [0002] Asparagus leaves are the dry leaves of Euphorbiaceae plant Sauropus spatuli folius Beille, mainly distributed in Guangxi, Guangdong, Fujian and other places, "Guangxi Materia Medica Selected Edition" (first edition) and "Guangxi Medicinal Plant Catalogue" all have load. The leaves of Longan are both edible and used as medicine: Zhuang medicine records that Longan leaves can ventilate the airways and valleys, moisten the lungs and relieve coughs, smooth the intestines and laxatives, and are used to treat coughs (coughs), chest tightness, and diarrhea due to the effect of moistening the lungs and relieving coughs. Yi Sac (constipation) is a commonly used strong medicine in clinical practice. The 2010 edition of "Chinese Pharmacopoeia" includes Longan ...

Claims

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Application Information

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IPC IPC(8): A61K36/47A61P1/04A61K127/00
Inventor 吴秀媛李玉梅林凯辛素文
Owner QINGDAO MUNICIPAL HOSPITAL
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