A kind of pharmaceutical composition for treating ulcerative colitis and application thereof

A kind of ulcerative colitis and composition technology, applied in the field of traditional Chinese medicine

Inactive Publication Date: 2017-07-18
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no literature report that the extract of Longan Leaf has the effect of treating ulcerative colitis

Method used

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  • A kind of pharmaceutical composition for treating ulcerative colitis and application thereof
  • A kind of pharmaceutical composition for treating ulcerative colitis and application thereof
  • A kind of pharmaceutical composition for treating ulcerative colitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Preparation of Dragon's Leaf Extract

[0016] Remove impurity, clean, pulverize and grind about 32 meshes. Weigh 10kg of the leaves powder and place it in a reflux extraction device. Add 85L of purified water to soak for 1 hour, then heat to reflux for 1 hour, and extract 2 times. The extracts were combined, concentrated under reduced pressure to 1.5 times (v / w) of the weight of the raw material of scorpion leaf, added with equal volume of ethyl acetate and extracted 3 times, combined the extracts, recovered the ethyl acetate and lyophilized with a freeze dryer, crushed, Delongia leaf extract.

Embodiment 2

[0017] Example 2 Preparation of Dragon's Leaf Extract

[0018] Remove impurity, clean, pulverize the leaves of dragon worms to a particle size of about 32 meshes, weigh 10 kg of powder of dragon worms leaves, place them in the extraction device, add 100L of purified water and soak for 1 hour, then heat and reflux for 1.5 hours, and extract 2 times. The extracts were combined, concentrated under reduced pressure to 1 time (v / w) of the weight of the raw material of scorpion leaf, added with an equal volume of ethyl acetate for extraction twice, combined the extracts, recovered the ethyl acetate and lyophilized with a freeze dryer, crushed, Delongia leaf extract.

Embodiment 3

[0019] Example 3 Therapeutic test study of the extract of serrata leaves on mice with ulcerative colitis

[0020] Forty healthy adult Kunming mice, male, weighing 20-24g, were randomly divided into the following 4 groups: blank control group, model control group, low-dose drug group, and high-dose drug group. The blank control group drank distilled water freely, and the other groups drank 5% dextran sodium sulfate aqueous solution freely for 6 days to create a mouse colitis model. During the modeling period, the blank control group and the model control group were intragastrically administered with normal saline every day; the low and high-dose drug groups were intragastrically administered with 50, 150 mg / kg Glycine max leaf extract daily (prepared in Example 1 of the present invention).

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PUM

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Abstract

The present invention relates to a pharmaceutical composition for treating ulcerative colitis and its application. It is prepared from the extract of Asparagus leaves and pharmaceutically available auxiliary materials. The extract of Asparagus leaves is prepared by the following method: weighing The raw material of asparagus leaves is removed, crushed, soaked in water and extracted under reflux, the extract is concentrated and then extracted with ethyl acetate, the obtained extract is recovered with ethyl acetate, freeze-dried to obtain the extract of asparagus leaves. The extract has significant therapeutic effect on ulcerative colitis.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine and relates to a pharmaceutical composition for treating ulcerative colitis and its application. Background technique [0002] The dry leaves of Sauropus spatuli folius Beille are the dried leaves of Sauropus spatuli folius Beille, which are mainly distributed in Guangxi, Guangdong, Fujian and other places. Both "Selected Materia Medica of Guangxi" (First Edition) and "List of Guangxi Medicinal Plants" Collection. Long 脷 leaves are both edible and used as medicine: Zhuang medicine records that long 脷 leaves can ventilate the airways and valleys, moisturize the lungs and relieve cough, smooth the intestines and relieve bowel movements. Because of the effects of moisturizing the lungs and relieving coughs, it is used to treat AIDS (cough), chest tightness, and Ah Italian sac (constipation) is a commonly used medicine in clinic. The 2010 edition of the "Chinese Pharmacopoeia" includ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/47A61P1/04A61K127/00
Inventor 吴秀媛李玉梅林凯辛素文
Owner QINGDAO MUNICIPAL HOSPITAL
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