2results about How to "Control inflammation" patented technology

The invention belongs to the field of medical instruments, and discloses a medical silica gel dressing fixing adhesive tape which comprises an adhesive tape body, and the adhesive tape body sequentially comprises a carrier layer, a silica gel adhesive layer and a stripping liner from outside to inside; the carrier layer is made of an elastic breathable material, and the silica gel adhesive layer is made of medical-grade organic silica gel; a plurality of first microcapsules are dispersed in the silica gel adhesive layer, the first microcapsules are drug-loaded microcapsules, and wall materials of the drug-loaded microcapsules are made of materials responding to the pH value, enzyme concentration or temperature change of a wound environment. Enzyme or ions are released after the second microcapsule is broken, the wall material of the first microcapsule is actively degraded, cascade response of'exudate increase-developing prompt-drug accelerated release 'is realized, a large amount of drugs are quickly released when the exudate appears, and infection or inflammation is effectively controlled.

The invention belongs to the technical field of medicines, and particularly discloses application of targeted mesenchymal stem cell NAT10 and RNA acetylation in inflammatory diseases. The invention reveals for the first time that NAT10 mediated ac4C modification is a key positive regulatory factor for regulating the immune function of mesenchymal stem cells (MSC), and an inflammatory environment can inhibit the pathway so as to cause weakening of the MSC function. Based on the discovery, NAT10 expression in the MSC is up-regulated through a genetic means, and the MSC with the enhanced function is prepared. The cell shows a higher ac4C acetylation level, and the expression of key immunosuppressive factors iNOS and COX2 and the secretion of products NO and PGE2 are remarkably improved, so that a stronger T cell inhibition capability is obtained. Animal experiments show that the MSC with the enhanced function shows a remarkably superior treatment effect compared with common MSC in disease models of inflammatory liver injury, periodontitis and the like.