Hypoglycemic application of petroleum ether extract from Derris eriocarpa

A technology of petroleum ether extraction and deer vine, applied to medical preparations containing active ingredients, drug combinations, plant raw materials, etc., can solve problems such as weight gain

Inactive Publication Date: 2019-01-15
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional anti-diabetic drugs may cause side effects such as hypoglycemia, gastrointestinal reactions, cardiovascular disease and weight gain

Method used

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  • Hypoglycemic application of petroleum ether extract from Derris eriocarpa
  • Hypoglycemic application of petroleum ether extract from Derris eriocarpa
  • Hypoglycemic application of petroleum ether extract from Derris eriocarpa

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] One, the preparation of deervine trichocarpa petroleum ether extract

[0013] Dried deer vine stems are cut into 0.5-1cm slices, crushed into coarse powder through a traditional Chinese medicine grinder, and passed through a 30-mesh sieve to obtain deer vine powder; weigh 1 kg of deer vine powder, and use 95% volume concentration After soaking the medicinal powder in ethanol for 24 hours, heat and reflux to extract twice, each time for 1 hour, combine the ethanol extracts, concentrate, and evaporate the ethanol to obtain the ethanol extract of Deervine trichome (92.5g); Suspended in water, added 500mL of petroleum ether for extraction, extracted 3 times, combined the extracts, concentrated, and finally obtained 20g of dark green deervine trichome petroleum ether extract extract.

[0014] 2. Pharmacological experiment on hypoglycemic effect of deervine trichocarpa petroleum ether extract in vitro

[0015] Experimental procedure

[0016] Hep62 cells in good growth state...

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Abstract

The invention discloses a hypoglycemic application of petroleum ether extract from Derris eriocarpa, having good effect on hyperglycemia of diabetes mellitus in particular. The results showed that theextract could increase the body weight of diabetic mice and decrease the blood glucose of mice, and increase the utilization rate of glucose of HepG2 cells in high glucose model. Experimental research shows that the extract of has better pancreatic protection, improvement of pancreatic pathological degree and hypoglycemic effect on streptozotocin-induced diabetic mice. As such, that present application provide a theoretical basis for further research and development of the Zhuang medicine Derris eriocarpa, so as to provide a novel modern traditional Chinese medicine preparation for treat diabetes by hypoglycemia effect for clinic.

Description

technical field [0001] The invention belongs to the technical field of Zhuang medicine Deervine trichomes, in particular to the hypoglycemic application of a deervine trichome petroleum ether extract. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia, and it is a chronic hyperglycemia syndrome caused by genetic, environmental, insulin secretion defects and other factors. In diabetes, the body's persistent high blood sugar and long-term metabolic disorder will damage the body's tissues and organs and cause dysfunction, which seriously endangers the health of diabetic patients. Drugs protect the pancreas to protect β cells and enhance insulin secretion to treat diabetes. However, traditional antidiabetic drugs may cause side effects such as hypoglycemia, gastrointestinal reactions, cardiovascular disease, and weight gain. Chinese herbal medicine and traditional medicine have long been reported in the literature on the treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P3/10
CPCA61K36/48A61K2236/333A61K2236/39A61K2236/51A61K2236/55
Inventor 杨立芳邓丽姚姜明国吴霜吴家法石松标郭洋洋姜昱
Owner GUANGXI UNIV FOR NATITIES
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