Gastrodia elata active ingredient composition for preventing and treating dementia and application thereof

An active ingredient and a technology for preventing and treating dementia, which is applied in the field of medicine, can solve the problems of Gastrodia elata singleness and unreported research, and achieve the effect of clear composition, rich source of raw materials, and easy industrial production

Inactive Publication Date: 2018-08-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above research shows that the current research mainly focuses on the single effective part of Gastrodia elata, and there is no report on the combination of several effective parts or active ingredients.

Method used

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  • Gastrodia elata active ingredient composition for preventing and treating dementia and application thereof
  • Gastrodia elata active ingredient composition for preventing and treating dementia and application thereof
  • Gastrodia elata active ingredient composition for preventing and treating dementia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Gastrodia elata composition on the impact of scopolamine-induced learning and memory impairment in mice

[0022] Animal model: scopolamine-induced learning and memory impairment in mice

[0023] Modeling, administration, and grouping: 60 male KM mice were randomly divided into 6 groups according to body weight: blank control group, model group, donepezil group, Gastrodia elata composition PNA-1~PNA-3 group, 10 mice in each group . The treatment group was given 2.5 mg / kg donepezil (dissolved with 2% Tween80+0.5% CMC-Na) and Gastrodia elata compositions PNA-1-PNA-3 by intragastric administration for 10 consecutive days (dosages are shown in Table 1). The blank control group and the model group were intragastrically given equal volumes of distilled water.

[0024] Test indicators: Morris water maze test was carried out on the 6th to 10th day. After 40 minutes of administration on the 6th to 9th day, except for the blank control group, the other groups were intr...

Embodiment 2

[0029] Example 2 Effect of gastrodia elata composition on scopolamine-induced learning and memory impairment in mice

[0030] Animal model, modeling, administration, grouping and detection are all the same as in Example 1, and the experimental results are as shown in Table 2:

[0031] Table 2 Results of water maze experiment

[0032]

[0033] ***P<0.001, compared with the normal group; #P<0.05, compared with the model group. Data are expressed as means±SEM, N=10.

[0034] The results show that: the ratio shown in PNA-5 has a good memory-enhancing effect, wherein P, N, and A are respectively a compound in the Ⅰ, Ⅱ, and Ⅲ components. In this example, they are parishin C, N6- The ratio of hydroxybenzyladenosine and p-hydroxybenzaldehyde is 95:1:4. In addition, this experiment shows that the P component is less than 70% or the N and A components are greater than 20%, and there is no significant difference between the measured indexes and the model group.

Embodiment 3

[0035] Embodiment 3 Gastrodia elata composition is on H2O2 Injury rat adrenal chromoma cell (PC12) survival rate influence

[0036] (1) Buried plates: set up a blank control group, a normal control group, a model control group, 9 drug-administered groups and a positive control group, with 3 replicate wells for each group. Add 160 μl of blank culture medium (DMEM / F12-10% serum) to the blank control group, add 160 μl of PC12 single cell suspension with a cell concentration of 8000 cells / ml to the remaining columns, and place the inoculated culture plate in a CO2 incubator for cultivation.

[0037] (2) Administration: After culturing for 24 hours, 40 μL of culture solution was added to each well of the blank group, normal group and model group, and 40 μl of each drug-containing culture solution with a final concentration of 100 μg / ml was added to each well of the administration group, respectively P, N , A, composition PNA-1, PNA-2, PNA-3, PNA-4, PNA-5, PNA-6 (in PNA-1~PNA-3, P, ...

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Abstract

The invention relates to the use of a gastrodia elata active ingredient composition in the preparation of medicines for preventing and treating dementia. The composition is composed of anti-dementia active ingredients I, II and III in the traditional Chinese medicine Gastrodia elata. The anti-dementia effect can be used to prepare medicines or health care products for preventing and treating dementia.

Description

technical field [0001] The present invention belongs to the field of medicine. Specifically, it relates to a composition prepared in different proportions from the active ingredients of the traditional Chinese medicine Gastrodia elata, and its use in the preparation of medicines for enhancing memory, improving intelligence, or preventing and treating diseases such as senile dementia. Background technique [0002] Senile dementia is a common and frequently-occurring disease in the aging society, which seriously threatens the quality of life and life safety of patients. Due to its complex etiology and pathogenesis, there is no specific medicine at present. Commonly used western medicines include brain metabolism activators, cholinergic drugs, etc., which are mostly symptomatic treatments. The overall prognosis is poor, and it has side effects such as liver toxicity and headache. The components of traditional Chinese medicine have the characteristics of multi-component and mul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/708A61K31/7076A61P25/28A61K31/7034A61K31/11A61K31/075
Inventor 肖红斌王莉刘欣欣唐春兰程孟春
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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