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Ointment for treating precancerous lesions of chronic atrophic gastritis and preparation method thereof

A technology for atrophic gastritis and precancerous lesions, applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as troublesome decoction and brewing, uncontrollable costs, and unpalatable medicines, and improve gastric Mucosal lesions and pathology, improvement of epigastric pain, and effect of relieving epigastric pain

Inactive Publication Date: 2020-03-27
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditional Chinese medicine has a remarkable curative effect, oral administration of traditional Chinese medicine (or decoction-free granules) has more or less problems such as inconvenience in carrying, troublesome decoction and ingestion, unpalatable medicine, difficult quality control, difficult cost control, and poor patient compliance. There are very few oral Chinese patent medicines with curative effect

Method used

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  • Ointment for treating precancerous lesions of chronic atrophic gastritis and preparation method thereof
  • Ointment for treating precancerous lesions of chronic atrophic gastritis and preparation method thereof
  • Ointment for treating precancerous lesions of chronic atrophic gastritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 prepares the ointment for the treatment of precancerous lesions of chronic atrophic gastritis

[0022] The prescription is: Astragalus 30g, Scutellaria barbata 18g, Coix seed 30g, Vinegar Trillium 6g, Angelica dahurica 9g, Kaempferia 6g, Shanzi mushroom 6g, Rhodiola rosea 12g, cinnamon 6g, borneol 3g.

[0023] Proceed as follows:

[0024] (1) Take Astragalus, Scutellaria barbata and Rhodiola rosea, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste;

[0025] Take Coix seed, Angelica dahurica and Arrowhead mushroom, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate, concentrate to a thick paste; ...

Embodiment 2

[0032] Embodiment 2 prepares the ointment for the treatment of precancerous lesions of chronic atrophic gastritis

[0033] The prescription is: Astragalus 28g, Scutellaria barbata 20g, Coix seed 28g, Vinegar Trillium 8g, Angelica dahurica 8g, Kaempferia 8g, Shanzi mushroom 5g, Rhodiola rosea 15g, cinnamon 2g, borneol 4g.

[0034] Proceed as follows:

[0035] (1) Take Astragalus, Scutellaria barbata and Rhodiola rosea, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste;

[0036] Take Coix seed, Angelica dahurica and Arrowhead mushroom, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate, concentrate to a thick paste; ...

Embodiment 3

[0043] Embodiment 3 prepares the ointment for the treatment of precancerous lesions of chronic atrophic gastritis

[0044] The prescription is: Astragalus 32g, Scutellaria barbata 16g, Coix seed 32g, Vinegar Trillium 5g, Angelica dahurica 10g, Kaempferia 5g, Shanzi mushroom 8g, Rhodiola rosea 10g, cinnamon 4g, borneol 2g.

[0045] Proceed as follows:

[0046] (1) Take Astragalus, Scutellaria barbata and Rhodiola rosea, add 8 times the amount of 50% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate , concentrated into a thick paste;

[0047] Take Coix seed, Angelica dahurica and Arrowhead mushroom, add 8 times the amount of 80% ethanol solution, heat and reflux for extraction twice, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol under reduced pressure at 50-60°C from the filtrate, concentrate to a thick paste;...

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Abstract

The invention discloses ointment for treating chronic atrophic gastritis precancerous lesion. The ointment is prepared from, by weight, 28-32g of Mongolian milkvetch roots, 16-20g of barbed skullcap herb, 28-32g of jobstears seeds, 5-8g of vinegar common burreed rhizomes, 8-10g of dahurian angelica roots, 5-8 parts of galanga resurrectionlily rhizomes, 5-8 parts of appendiculate cremastra pseudobulb, 10-15g of integripetal rhodiola herb, 2-4g of cassiabarktree barks and 2-4g of borneol. When the ointment is used for treating the chronic atrophic gastritis precancerous lesion, the ointment is applied on a Zhongwan point, a Zusanli point, a Pishu point and a Weishu point by the aid of a point application therapy method, gastric mucosal lesion and pathology of patients can be obviously improved, the ointment can effectively improve the symptoms such as gastric cavity pain, gastric cavity distention and fullness, anorexia and debilitation, gastric upset and eructation, the living quality of the patients is improved, the treatment effect of the ointment is obviously superior to that of that of Qilian shupi Granule and Weifuchun, and a statistic difference exists (P<0.05).

Description

technical field [0001] The invention relates to an ointment for treating precancerous lesions of chronic atrophic gastritis and a preparation method thereof. Background technique [0002] Chronic atrophic gastritis (Chronic Atrophic Gastritis, CAG) is a common and frequently occurring disease of the digestive system, because it has a certain relationship with the occurrence of gastric cancer. In 1978, WHO listed it as a precancerous disease or precancerous state of gastric cancer. Gastric cancer is the most common malignant tumor, which seriously endangers human health. Gastric mucosal cancer is not a "jump" from normal cells to cancer cells, but a multi-step process of canceration, that is, chronic superficial gastritis → atrophic gastritis → intestinal metaplasia → dysplasia → gastric cancer. The lesions that appear during this period are called precancerous lesions. Precancerous lesions refer to a kind of pathological and histological changes of gastric mucosa that are ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/906A61K9/70A61P1/04A61P1/14A61K31/045
CPCA61K9/7053A61K31/045A61K36/232A61K36/41A61K36/481A61K36/539A61K36/54A61K36/898A61K36/8994A61K36/902A61K36/906A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 曹志群王晓妍王伟王建波张新王永森胡东青陈婷薛晔
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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