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Biflavone compound with neuroprotective effect and extraction and separation method thereof

A technology for bisflavonoids and compounds is applied in the fields of bisflavonoids and their preparation, preparation of neuroprotective drugs, and antidepressant effects, and can solve the problems of low economic added value, improve the LDH leakage rate, and the preparation method is simple and convenient. The effect of improving the survival rate

Active Publication Date: 2020-11-20
大连五舟神草健康科技有限公司
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Problems solved by technology

At present, peacock grass is a common flower bed landscape plant, which is rarely used in China and has low economic added value. If the flowers of peacock grass can be recycled and reused after the flowering period, it can not only reduce the burden on the environment but also avoid the waste of resources

Method used

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  • Biflavone compound with neuroprotective effect and extraction and separation method thereof
  • Biflavone compound with neuroprotective effect and extraction and separation method thereof
  • Biflavone compound with neuroprotective effect and extraction and separation method thereof

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Embodiment Construction

[0026] The invention provides a kind of biflavonoid compound, molecular formula is C 33 h 24 o 14 , the chemical structure is as figure 1 shown.

[0027] The biflavonoids are named as 8,8'-methylenebis(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-chromone according to the structural name (8,8'-methylenebis(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one)), Table 1 shows the diflavonoid compound in DMSO-d 6 NMR data for the test solvent.

[0028] Table 1. NMR data of bisflavonoids.

[0029]

[0030] 1. A preparation method of biflavonoids.

[0031] Step 1. Take 8 kg of dried peacock grass flowers, cut them into pieces and grind them into powder. The weight ratio of dry malachite herb powder and ethanol aqueous solution is 1:8-15, and reflux extraction is carried out for 1-3 times, each time for 3-10 hours. Preferably, 10 times the amount of 95% ethanol is refluxed and extracted three times, each time for 6 hours. Filter and concentrate the extrac...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a biflavone compound extracted from maidenhair flowers as well as a preparation method and application thereof. The molecular formula of the biflavone compound is C33H24O16, the biflavone compound is named as 8,8'-methylene bis(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone, the chemical structural formula of the biflavone compound is shown in the specification, and the biflavone compound is used for preparing neuroprotective drugs. The preparation method sequentially comprises the following steps: ethanol extraction, n-butyl alcohol extraction, silica gel column chromatography, polyamide, and Sephadex LH-20. According to the method, the biflavone compound with high purity can be simply, conveniently and quickly extracted and separated, has a neuroprotective effect, can be prepared into tablets, granules, capsules and other dosage forms by being supplemented with pharmaceutically common auxiliary materials, and is used for improving and treating depression and other neurological diseases. Therefore, the biflavone compound can be used as a natural product to develop new drugsof traditional Chinese medicines, and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a biflavonoid compound extracted from Malachite flower, its preparation method and its use in the preparation of neuroprotective drugs, especially having antidepressant effect. Background technique [0002] Peacock grass (Tagetes patula L.) is recorded in "Guizhou Herbal Medicine" as a national medicine of the Yi nationality. It has the effects of clearing heat and detoxifying, nourishing blood and dredging menstruation, relieving cough, and can effectively relieve symptoms such as toothache, oral ulcer, red eyes, swelling and pain. In South America, residents often use malacock grass as tea to achieve the purpose of lowering blood fat, protecting liver, lowering blood pressure, preventing and treating cardiovascular diseases. In addition, it is also used in the Russian Far East as a folk medicine for prolonging life (Sneha Nawale; K.Padma Priya; P.Pranusha; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/40A61K31/352A61P25/00A61P25/24
CPCC07D311/30C07D311/40A61P25/00A61P25/24
Inventor 窦德强刘琳琳罗思敏窦培元蔡德成
Owner 大连五舟神草健康科技有限公司
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