New skeleton large ring mixed peptide polyketide and preparation method and application thereof

A compound and drug technology, applied in the field of new skeleton macrocyclic mixed peptide polyketide compound, can solve the problem of no isolated compound and achieve the effect of inhibiting apoptosis

Active Publication Date: 2019-12-20
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there is no report of isolating the compound of the present invention from Fukang tree

Method used

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  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof
  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof
  • New skeleton large ring mixed peptide polyketide and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0046] Embodiment 1, the preparation of compound of the present invention

[0047] 1. Experimental materials

[0048] 1.1 Experimental reagents

[0049] Column chromatography silica gel, 200-300 mesh (experimental grade), Qingdao Haiyang Silica Gel Desiccant Factory.

[0050] MCI gel CHP 20P, 75-150 μm, Mitsubishi Chemical Corporation, Japan.

[0051] gel ODS-A, 50 μm, Japan YMC Company.

[0052] Analytical reagents such as petroleum ether, ethyl acetate, and acetone were purchased from Chengdu Kelong Chemical Reagent Factory.

[0053] 1.2 Experimental Instruments

[0054] Q-TOFII high-resolution time-of-flight mass spectrometer (Bruker, USA);

[0055] Bruker-AV-800 nuclear magnetic resonance instrument (Bruker, Switzerland);

[0056] Fourier transform infrared spectrometer (Perkin-Elmer);

[0057] V-650 UV spectrometer (JASCO);

[0058] RE-2000B rotary evaporator (Shanghai Yarong Instrument Company);

[0059] Perkin-Elmer 341 polarimeter (Perkin-Elmer, USA);

[0060] ...

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Abstract

The invention discloses a new skeleton large ring mixed peptide polyketide and a preparation method and application thereof. The invention provides the compound shown as a formula I (please see the specification for the formula I), or a stereoisomer, a crystal form or a pharmaceutically acceptable salt thereof, wherein in the formula I, R is selected from hydrogen, hydroxyl, halogen, C1-C4 alkoxyand C1-C6 alkyl. The invention further provides the preparation method and application of the compound. Experimental results prove that the compound provided by the invention can inhibit apoptosis ofnerve cells, has a neuroprotective effect, can be used as a potential drug for preventing and treating neurodegenerative diseases, and provides a new drug option for clinical application.

Description

technical field [0001] The invention relates to a new skeleton macrocyclic mixed peptide polyketide compound and its preparation method and application. Background technique [0002] Voacanga africana Stapf., also known as African potato fruit, is a plant of the genus Voacanga of the family Apocynaceae, mainly produced in West Africa, Congo, Tanzania and other places. It occupies an important position in the field of African traditional medicine and is often used in the treatment of leprosy, dysentery, generalized edema, convulsions in children, epilepsy, diuretics, and tonics for children. Decoctions of stems and bark were used to treat mental disorders, and the gum was used to granulate calendars. The decoction of the bark is considered an analgesic and is added to bruise medicine. A decoction of the bark and root was also used to treat heart cramps. Decoctions of the bark and roots are also used to treat choking, fruit decoctions are used as a disinfectant, and leaf de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D267/00A61K31/395A61P25/00A61P25/28
CPCC07D267/00A61P25/00A61P25/28
Inventor 邓赟李鸿翔谭玉柱刘海峰但小梅郭大乐彭腾
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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