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Biological agent with neuroprotective effect

A technology of neuron protection and biological preparations, which is applied in the field of medicine, can solve problems such as the route of administration and the way of administration have not been well resolved, and achieve the effect of improving symptoms and reducing local inflammatory reactions

Inactive Publication Date: 2015-03-25
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, issues such as the route of drug administration in the central nervous system, the method of administration, whether the drug can penetrate the blood-brain barrier, and whether neurons can absorb the drug through layers of glial cells have not been well resolved.

Method used

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  • Biological agent with neuroprotective effect
  • Biological agent with neuroprotective effect
  • Biological agent with neuroprotective effect

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Experimental program
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Effect test

Embodiment

[0019] 1. Measure the temperature-sensitive hydrogel and activin B according to the proportion, operate on ice, gently pipette and mix well, and prepare preparations with different concentrations. The concentration of activin B in preparations 1 to 4 is 10 ng in sequence / μl, 15ng / μl, 20ng / μl, 25ng / μl.

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Abstract

The invention discloses a biological agent with the neuroprotective effect. A temperature sensitive hydrogel coats an activin B to obtain a composite biological agent. The activin B has neuroprotective effect, the novel temperature sensitive hydrogel has neuroprotective effect, and functions of inflammation inhibition and slow release; the activin B in the composite biological agent slowly releases in the brain to play drug effect. The biological agent can synergistically inhibit mice corpus striatum dopaminergic neuron injury caused by Mptp, reduce local inflammation reaction, and improve the symptoms of Parkinson's disease from the perspective of behavioristics. The invention provides important medication reference for the clinic treatment of Parkinson's disease and other neurodegeneration diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a biological preparation with neuron protection effect. Background technique [0002] Parkinson's disease (PD) is a common movement disorder among middle-aged and elderly people with progressive degeneration of dopaminergic neurons in the substantia nigra of the midbrain and lack of neurotransmitter dopamine as the main pathological and biochemical basis. Its clinical symptoms mainly manifest as resting tremor, muscle rigidity, and bradykinesia. Recent epidemiological surveys show that the incidence of Parkinson's disease among people over 65 years old in my country is 1.7%, and the average survival period from diagnosis to death is 15 years. The etiology and pathogenesis of Parkinson's disease are very complex and have not been fully clarified so far. All current treatments for Parkinson's disease are symptomatic treatments, and there is no radical cure. Carrying ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61K47/32A61P25/16A61P25/00
Inventor 张璐张琳顾晶晶
Owner SOUTHERN MEDICAL UNIVERSITY
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