The invention belongs to the technical field of medicines, and particularly relates to a linarin targeted slow-release nano
drug-loading
system as well as a preparation method and application thereof. A
polylactic acid-polyglycolic acid
copolymer is used as a matrix,
polyvinyl alcohol is used as a cross-linking agent, and coated
drug-loaded microspheres are formed through cross-linking and
grafting of the matrix and the cross-linking agent; and then
chitosan is used as a protective agent,
chitosan and the coated
drug-loaded microspheres are crosslinked and grafted to form double-coated composite drug-loaded microspheres, the
chitosan in the composite drug-loaded microspheres is used as a shell, the coated drug-loaded microspheres are used as a core, and the linarin targeted slow-release nano drug-loaded
system is obtained. Through the double-target design, the targeting property to
cornea and
lacrimal gland is enhanced, the treatment efficiency of the
medicine is improved, stable release and
continuous release of linarin are realized, and the problem of unstable release of the
medicine is solved; in addition, the targeted slow-release nano drug-loading
system is combined with the anti-inflammatory activity and the mitochondrial protection function of linarin, so that the side effects on eyes are reduced, and the safety is improved.