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Trophic factors: The use of trophic factors for neuroprotection in CNS disorders is being explored, specifically in ALS. Potentially neuroprotective trophic factors include CNTF, IGF-1, VEGF, and BDNF. Anti protein aggregation agents: Protein aggregation is a known source of neuron cell death.
Use of lapf and agonists thereof for the preparation of a medicament for the treatment or prevention of post-herpetic neuralgia
This invention belongs to the field of biomedicine and provides the application of LAPF and its agonists in the preparation of drugs for the treatment or prevention of postherpetic neuralgia. This invention targets spinal microglia by administering LAPF protein, a gene vector encoding LAPF, or an upregulator of their expression / activity, restoring their antiviral immune function, inhibiting neuroinflammation, and promoting the expression of neuroprotective factors. Animal experimental results show that administering LAPF protein, a gene vector encoding LAPF, or an upregulator of their expression / activity can significantly reduce mechanical hyperalgesia, decrease HSV-1 / VZV-related nerve damage, and effectively alleviate symptoms of chronic neuralgia.
Owner:THE NAVAL MEDICAL UNIV OF PLA