19 results about "Nitric acid ester" patented technology

A method for preventing, ameliorating or treating one or more disease or disorders selected from the group consisting of a skin disease, skin aging or steroid-induced skin atrophy, erectile dysfunction, and hair loss, comprises transdermally administering a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.WhereinR1 is C1-C3alkyl;R2 is H, CHO or CH═N—OH;R3 is C1-C4alkyl;R4 is C1-C6alkyl;R5 is SO2NR6R7;wherein R6 and R7 are together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein said heterocyclic ring is selected from piperidine and piperazine, wherein said heterocyclic ring is substituted with at least one R8, and wherein said R8 is independently selected from C1-C6alkyl optionally substituted with OH, ONO2, wherein at least one of said at least one R8 comprises at least one ONO2 moiety.

The invention relates to a method for drying and / or cleaning, preferably drying and cleaning aliphatic or cycloaliphatic nitrate esters (nitrate esters), in particular for removing water and volatile and / or volatilizable impurities, in particular generated during the production and / or washing of nitrate esters, the invention also relates to a corresponding use and to a corresponding device and system for carrying out the method.

The present invention relates to a process for the preparation of α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate and to the α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate.

The invention discloses a preparation method of 4, 6-dichloro-5-methoxypyrimidine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking dimethyl methoxymalonate as a raw material, generating 2-amino-4, 6-dihydroxy-5-methoxypyrimidine from dimethyl methoxymalonate and guanidine salt under the action of sodium ethoxide; then under the action of tert-butyl nitrite, lithium chloride, salicylic acid and tris (pentafluorophenyl) boron, 4, 6-dihydroxy-5-methoxypyrimidine is generated; finally, under the action of phosphorus oxychloride, 4, 6-dichloro-5-methoxypyrimidine is generated. According to the route, in the first step, a 2-aminopyrimidine product is generated through guanidine salt, in the second step, amino is eliminated through azotization, and the synthesis method of the compound is enriched.

The invention belongs to the technical field of organic matter synthesis, and relates to a preparation method of 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, and the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide is synthesized by dissolving N-(2, 2, 2-trifluoroethyl)-2-haloacetamide, nitrite ester, hydrazine, alkali and a catalyst in an alcohol solvent and carrying out one-pot reaction in the presence of hydrogen. The invention provides a new method for preparing the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, provides a new scheme with good yield for the preparation of the 2-amino-N-(2, 2, 2-trifluoroethyl) acetamide, and has important practical significance and practical value.

The present invention belongs to the technical field of chemical synthesis, and particularly relates to a method for synthesizing flecainide. 4-Bromo-2-methyl-benzoic acid undergoes a substitution reaction with n-butyl vinyl ether to generate 4-acetyl-2-methylbenzoic acid, which successively undergoes a condensation reaction with 2-amino-N-(2,2,2-trifluoroethyl)acetamide, an addition reaction with 3,5-dichlorobenzaldehyde, an isocyclization reaction with tert-butyl nitrite, a substitution reaction with (trifluoromethyl)trimethylsilane, and preferably a heating reaction to generate flecainide. By controlling the types and dosages of catalysts in each step of the reaction, each step of the reaction has a high yield, and finally flecainide is obtained with a high yield.

The invention discloses a catalyst for synthesizing nitrous acid ester and a preparation method thereof. The catalyst is composed of the following components: a main active component loaded on a carrier, wherein the main active component is noble metal, and the loading amount is 0.5-5wt% of the mass of the carrier; the carrier is a modified mesoporous molecular sieve, and the loading capacity is 40-60% of the mass of the carrier; the cocatalyst is a rare earth metal oxide, and the loading capacity is 5-15% of the mass of the carrier; the acid catalyst is p-toluenesulfonic acid, and the loading capacity is 0.3%-1.5% of the mass of the carrier. The invention relates to a preparation method and application of a catalyst for synthesizing nitrite, and the catalyst has the beneficial effects that the catalyst is a heterogeneous catalyst which is high in catalytic activity, good in stability and reusable, in an esterification reaction of alcohol and nitrite, the activity of the catalyst is improved by more than 30%, and the reaction time is shortened to 2-4 hours; after the catalyst is recycled for 5 times, the catalytic activity is still kept above 90%; the product selectivity reaches 98% or above, and no complex purification step is needed.

Aspects of the present invention are directed to structurally modified opioids (SMOs) that result in improved modulating activity at the NMDAR and improved PK and PD parameters over existing drugs with NMDAR modulating activity. The structural modifications of an opioid or opioid enantiomer that result in the SMOs can be obtained by starting the synthetic process de novo; by modifying the synthetic process for the opioid at any intermediate step during the synthesis of the racemate or of one enantiomer; or by modifying the structure of the opioid or opioid enantiomer after the synthesis. The nitric acid ester substitutions are of particular relevance, especially when associated to deuterated substitutions and / or halogen substitutions.

A sensitivity trap comprises a polymer matrix, an analyte(s) within the polymer matrix and a plasticizer. An amount and type of the plasticizer is sufficient to increase a diffusion coefficient of the

The invention belongs to the field of chemical synthesis, and particularly relates to a synthetic method of m-trifluoromethyl acetophenone, which comprises the following steps: 1, preparing nitrite through nitrosation reaction, 2, simultaneously dropwise adding the nitrite and m-trifluoromethyl aniline into an acetic anhydride substrate for reaction to directly obtain a product m-trifluoromethyl acetophenone feed liquid, and 3, carrying out post-treatment to obtain the m-trifluoromethyl acetophenone. And washing and rectifying to obtain the product. According to the scheme, the process route of preparing the m-trifluoromethyl acetophenone through diazotization, coupling and acidolysis reaction in the traditional process is broken through, the nitrite and the m-trifluoromethyl aniline react with the acetic anhydride under the action of the catalyst to directly synthesize the m-trifluoromethyl acetophenone in one step, the reaction steps are shortened, the generation of wastewater is greatly reduced, and the production cost is reduced. And the effect of reducing the cost is achieved.

Pharmaceutical compositions including R-MDMA salts O-Methyl Mandelate Form A, Nitrate Form A, and Mandelate Form B exhibit properties that are favorable for a pharmaceutical active ingredient. Methods of treating disorders, including neurological disorders, by administration of these compositions are described.

The application discloses a macromolecular NO donor hydrogel precursor solution for promoting wound healing and a preparation method and application thereof, and belongs to the field of medicinal polymer materials; the preparation method comprises the following steps: nitrate cyclic carbonate monomers are subjected to ring-opening polymerization under the action of an initiator and a catalyst to obtain a polymer functionalized at the end with a hydroxyl group, the polymer is then activated by nitro chloroformic acid ethyl ester, and then reacted with polyacetimide to obtain a polycarbonate block copolymer containing an NO donor; aldehyde groups are introduced into hyaluronic acid under the action of an oxidizing agent to form oxidized hyaluronic acid, and then the oxidized hyaluronic acid is reacted with dopamine to obtain dopamine-modified oxidized hyaluronic acid; the polycarbonate block copolymer containing the NO donor and the oxidized hyaluronic acid are respectively dissolved in an aqueous solution, and then an oxidizing agent is added to induce the formation of a hydrogel precursor solution. After the hydrogel precursor solution is administered orally, by injection or externally, the hydrogel precursor solution is further formed into a gel in situ under the oxidizing condition at a lesion site, NO is precisely and slowly released, and the effect of promoting wound healing is achieved.

A method for producing oxidized lignin includes providing a material including lignin; oxidizing the lignin in the material to form oxidized lignin, the oxidized lignin includes a reactive group; and collecting the oxidized lignin. The reactive group can include a carboxyl (-COOH) functional group, a hydroxyl (-OH) functional group, an aldehyde (-CHO) functional group, or a nitrate ester (-ONO2). The material can include organic waste, agricultural residues, plant-based materials, synthetic or genetically modified lignin, or industrial byproducts. The oxidized lignin can include molecular fragments, oligomers, or monomers.

The application discloses a micro-reaction synthesis method of trimethylolethane trinitrate. The method comprises the following steps: continuously feeding trimethylolethane aqueous solution and mixed nitric-sulfuric acid into a micro-channel reactor by a power pump respectively, with a total flow rate of 60 mL / min-70 mL / min, mixing and reacting at 5-15 DEG C, feeding into ice water after the reaction is completed to terminate the reaction, adding dichloromethane to extract, then washing with alkali and water, removing the extractant by rotary evaporation, and obtaining trimethylolethane trinitrate. The micro-channel reaction system is used to continuously synthesize trimethylolethane trinitrate, the temperature and flow rate in the reaction can be accurately controlled, the mixing effect and mass transfer efficiency of the reactants are significantly improved, the process is mild, the operation can be continuous, and the product has high quality and high yield.

This invention discloses a method for preparing 6,10,10-trinitro-2-oxa-6-azaadamantane-4,8,9-triol trinitrate, belonging to the field of organic synthesis technology. Using 1,3,5,7-cyclooctatetraene as a starting material, the method involves oxidative cyclization, ammonolytic cyclization, Boc protection and silane ether protection, secondary alcohol oxidation, deBoc acetylation, oximeization, geminitrohydration, and nitration to finally synthesize 6,10,10-trinitro-2-oxa-6-azaadamantane-4,8,9-triol trinitrate. The synthesis method is simple, and the final product exhibits stable properties. This invention addresses the lack of research on "azaadamantanes" (alkanes with nitrogen and oxygen heteroatoms synergistically introduced onto the same adamantane skeleton) and the general lack of substituents available for in-depth functionalization in existing adamantane skeleton construction methods. Furthermore, it introduces six explosive groups into the synthesized skeleton, resulting in a product with high density and excellent detonation performance.

The invention discloses a polycarbonate copolymer, a nano-micelle, a preparation method and application, a nitrate-containing cyclic carbonate structure is synthesized through nitration reaction, the polycarbonate copolymer is further prepared from a nitrate cyclic carbonate monomer and an initiator through ring opening polymerization, and the polycarbonate copolymer has the advantages of high yield, high purity, environmental friendliness and the like. Compared with a traditional method, the method is more suitable for large-scale production, realizes controllable synthesis of multi-element rings, and has a wide clinical application prospect; moreover, in combination with a nanofluidic technology, accurate control of assembly conditions of the macromolecular nitric oxide donor nano-micelle is realized, directional synthesis of a multi-element ring can be realized through simple condition adjustment in a reaction system, the development cost is reduced, and the difference between high reaction activity of a six-membered ring and stability of a seven-membered ring is reduced. And a new strategy is provided for NO release kinetics regulation and control.

The invention provides a kettle type overflow synthesis method of a glycerol trinitrate / diethylene glycol dinitrate mixture. The kettle type overflow synthesis method comprises the following steps: step 1, mixing concentrated nitric acid and concentrated sulfuric acid to prepare nitric acid and sulfuric acid mixed acid; mixing glycerol with diethylene glycol to obtain mixed polyol; step 2, continuously pumping the mixed acid of nitric acid and sulfuric acid and the mixed polyol according to the formula ratio into an overflow reaction kettle by virtue of a metering pump, carrying out nitration reaction, and enabling a reaction product to flow out of an overflow port of the reaction kettle and enter a separator; step 3, separating in a separator to obtain an organic phase; 4, the organic phase enters a collecting tank after being subjected to water washing and alkali washing, and a glycerol trinitrate / diethylene glycol dinitrate mixture is obtained. According to the method disclosed by the invention, a kettle type overflow synthesis method is adopted, so that the process operation is simplified, the online amount of reaction is reduced, the safety of a nitration reaction process is improved, and the reaction yield of a glycerol trinitrate / diethylene glycol dinitrate mixture is improved.

The hydrazine-containing composition is a liquid mixture that includes from 5 mol % to 95 mol % of unprotonated hydrazine selected from hydrazine, monomethylhydrazine, dimethylhydrazine, ethylhydrazine, and combinations thereof, and from 5 mol % to 90 mol % of at least one oxygen-containing solute or solvent selected from acetals, acetyls, alcoxyamines having two or more carbon atoms, aldehydes, amides, amides and particularly carboxamides, aminoalcohols, carbazides, semicarbazides, carbon-containing nitrate salts comprising cations with logarithmic dissociation constants less than 9.2, hydroxyalkyl nitro compounds, hydroxyalkylhydrazines, carbonates, carboxylic acids and anhydrides of carboxylic acids, esters, ethers, ketals, ketones, mono- and poly-alcohols in 31% or greater mass fraction, nitrate esters, nitrosamines, sugars, and combinations thereof. The unprotonated hydrazine has a first vapor pressure and the oxygen-containing solvent has a second vapor pressure that is less than the first vapor pressure.