Preparation method of genistein nitric oxide donor type derivant and uses thereof

Abstract

The present invention provides a dye lignin derivative containing nitrogen monoxide donor, and in particular relates to a compound which is produced by ester bond connection of dye lignin (Genistein, Gen) and nitric acid ester NO (nitrogen monoxide) donor. The precursor derivative of nitrogen monoxide donor dye lignin (NO-G) with connected ester bonds is produced through chemical reaction between dye lignin (genistein) and a corresponding nitric acid ester NO donor. The ester bonds are broken in the structure through biological changes and drift out of the original drug Gen and the NO donor; NO can be slowly released to coordinate with the Gen, and the dual coordinated anti-tumor mechanism demonstrates excellent effects on apoptosis inhibition for ovary cancer and apoptosis induction of the ovary cancer.

Description

technical field [0001] The present invention relates to a novel genistein nitric oxide donor derivative, its preparation process, as a compound with anti-tumor activity, after biotransformation in vivo, the ester bond is broken, and the original drug genistein (Genistein, Gen) and The NO donor part, the latter can slowly release NO, and act synergistically with Gen, through a dual synergistic anti-tumor mechanism, it has shown a good effect on inhibiting the proliferation of ovarian cancer cells or inducing the apoptosis of ovarian cancer cells, specifically a New compounds for the treatment of gynecological tumors. Background technique [0002] Ovarian tumor is one of the three most common malignant tumors of female genitalia. Among them, the mortality rate of ovarian cancer ranks first among gynecological malignancies. Most patients are in the middle and advanced stages when they see a doctor. . The first choice of treatment for ovarian cancer is surgery and chemotherap...

AI Technical Summary

Problems solved by technology

However, as a gas signal molecule, NO has a short half-life in the body, is unstable, and has poor controllability. Therefore, more and more researches focus on using specific carriers to couple with NO donors to release NO at a certain site. achieve the effect of killing cancer cells

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