11 results about "Developing nervous system" patented technology

The invention relates to the technical field of medical diagnosis, and discloses a fetal nervous system auxiliary diagnosis method based on big data. The method comprises the following steps: collecting nervous system monitoring data of a plurality of fetuses; performing prenatal whole pregnancy dynamic tracking regularization processing on the ultrasonic radio frequency signal sequence, aligning ultrasonic characteristic differences among different fetuses, and generating a fetal nervous system development ultrasonic characteristic dynamic change curve; obtaining a non-pathological feature weight and an optimized association degree quantity of each sampling point, calculating a comprehensive importance score of each sampling point based on a product of the non-pathological feature weight and the optimized association degree quantity, and selecting the sampling points of which the scores are higher than a dynamic threshold value as key feature points; integrating amplitude data and clinical health scores of the regularized feature dynamic change curves of all fetuses at key feature points, and training a diagnosis prediction model by using a gradient boosting decision tree algorithm; and processing the ultrasonic radio frequency signal sequence of the fetus by using the diagnosis prediction model, extracting the amplitude of the key feature points, inputting the amplitude into the model, and outputting a nervous system development outcome risk prediction evaluation value.

The invention belongs to the field of nutrient substance research, and particularly relates to a nutrient composition for improving brain development. The nutritional composition provided by the invention comprises necessary active ingredients shown in the following (i) and (ii): (i) lactose-N-neotetraose, (ii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and (iii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine. The nutritional composition comprises lactose-N-neotetraose and 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine is 1: (0.010-2.5). The research shows that the combination of the lactose-N-neotetraose and the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine can be used for improving offspring brain immune disorder and / or nervous system dysplasia caused by maternal immune activation, and the lactose-N-neotetraose and the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine have a synergistic interaction effect.

The invention belongs to the field of food, and particularly relates to a nutritional composition and application thereof in improving intestinal microecology. The invention provides application of a nutritional composition in preparation of food for improving offspring intestinal microecological imbalance caused by maternal immune activation. The nutritional composition comprises essential active ingredients shown as the following (i) and (ii): (i) a neutral fucosylated breast milk oligosaccharide, (ii) a neutral non-fucosylated breast milk oligosaccharide; wherein the neutral fucosylated breast milk oligosaccharide at least comprises 2 '-fucosylated lactose, and the neutral non-fucosylated breast milk oligosaccharide at least comprises lactose-N-neotetraose; moreover, in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 2 '-fucosyllactose is 1: (1-9), and the 2'-fucosyllactose and the lactose-N-neotetraose can achieve a synergistic effect to improve the intestinal microecology of the offspring and provide benefits for the development of the nervous system of the offspring.

The invention discloses a coccidoxane sesquiterpene CNA as well as a preparation method and application thereof, and belongs to the field of traditional Chinese medicine preparation. According to the present invention, cold soaking, silica gel and gel column chromatography are adopted to separate and extract the cocculin type sesquiterpene CNA compound represented by a formula I from coriaria sinica linn; the CNA compound has a novel cis-hydrogenated indene core structure, contains nine continuous chiral centers, has the characteristic of a highly crowded polycyclic skeleton, and has good biological activity. Cell experiments show that the coccidoxane sesquiterpene CNA can inhibit signal transduction of GABAB receptors in endogenous and exogenous systems, and can be used for preparing drugs for treating or preventing nervous system related diseases. A new direction is opened up for developing novel GABAB receptor antagonists or modulators, exploring GABA receptor related therapeutic targets and developing nervous system disease drugs.

The invention belongs to the field of food, and particularly relates to a nutritional composition for improving intestinal microecology and application thereof. The nutritional composition provided by the invention comprises necessary active ingredients as shown in the following (I) and (II): (I) lactose-N-neotetraose, (II) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and (f) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, the nutritional composition comprises lactose-N-neotetraose and 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine is 1: (0.010-3.0). Researches show that lactose-N-neotetraose and 1, 2-diacyl-sn-glycerol-3-phosphorylcholine can improve offspring intestinal microecological imbalance caused by maternal immune activation in a synergistic manner, and benefit is provided for offspring nervous system development.

A method for treating or reducing the severity of neurodevelopmental defects in a developing nervous system after exposure to an anesthetic by modulating or inhibiting caspase activity, for example, by administering a pan-caspase inhibitor such as pan-caspase inhibitor Q-VD-OPh to a subject having or at risk of congestive heart disease and / or having a ciliopathic disorder.

The present application belongs to the field of food, and particularly relates to a nutritional composition for improving intestinal microecology and use thereof. The nutritional composition provided by the present application comprises essential active ingredients shown in (I) and (II) as follows: (I) lacto-N-neotetraose, (II) 1,2-diacyl-sn-glycero-3-phosphocholine; and in the nutritional composition, the mass ratio of the lacto-N-neotetraose to the 1,2-diacyl-sn-glycero-3-phosphocholine is 1:(0.010-3.0). Studies show that both lacto-N-neotetraose and 1,2-diacyl-sn-glycero-3-phosphocholine can synergistically improve the intestinal microecological imbalance of offspring caused by maternal immune activation and provide benefits for the nervous system development of offspring.

The invention discloses an MXene / enzyme modified acetylcholine nano microelectrode and application of the MXene / enzyme modified acetylcholine nano microelectrode in analysis of acetylcholine released by a single vesicle. The MXene / enzyme modified acetylcholine nano microelectrode constructed by the invention is used for analysis of acetylcholine released by the single vesicle. The method sequentially comprises the following steps: construction of an acetylcholine nano microelectrode, preparation of an acetylcholine artificial vesicle, extraction and culture of mouse primary cholinergic neurons, and release detection of acetylcholine in a single vesicle. A new thought and a new method are provided for monitoring the release condition of the acetylcholine single vesicles at the single cell level, and the method has important significance in studying nervous system development, understanding the physiological and pathological processes of nervous system diseases and regulating rules in treatment.

The utility model discloses a balance table for exercising hand-eye coordination of children, which comprises a long-strip-shaped table body, side baffles are arranged on two sides of the table body along the length direction, a fixed baffle and a game panel are respectively arranged on two sides of the table body along the width direction, and a plurality of arranged spacing plates are arranged on the table body along the length direction. A barrier area is formed between every two adjacent partition plates, a movable device capable of rotating universally is installed on the fixed baffle, a game bridge is fixed to the movable device, an operating rod is installed at the other end of the game bridge, and the operating rod extends out of the table body from the game panel. The ball rolls into a target level area through the game bridge, so that the effects of exercising the matching ability of eyes and hands of children and the reaction speed, promoting nervous system development, improving the athletic ability and the learning ability, cultivating confidence and achievement, promoting the children to be willing to accept challenges, forming a virtuous circle and promoting comprehensive physical and mental development are achieved.

The invention discloses a newborn encephalopathy assessment system, and relates to the technical field of newborn encephalopathy assessment. The invention aims to improve the evaluation effect on neonatal encephalopathy. Comprising a whole body motion (GMs) quality evaluation unit which can record and analyze activity awakening state videos of the newborns so as to identify and classify GMs of the newborns and identify high-risk children with abnormal motion development in the early stage; and the neurology evaluation unit is used for evaluating the maturity of the nervous system of the newborn by detecting a plurality of indexes such as adaptive capacity, muscular tension and original reflex of the newborn. According to the neonatal training system, the whole-body movement quality of the neonatal is evaluated, multiple indexes such as the adaptive capacity, the muscular tension and the original reflex of the neonatal are comprehensively evaluated in combination with the neurology evaluation unit, and the comprehensive evaluation is beneficial for doctors to more accurately know the nervous system development condition of the neonatal, so that a personalized treatment scheme is formulated, and the neonatal training efficiency is improved. The treatment effect is improved.

The invention discloses a three-dimensional brain organ culture method based on electric field stimulation, and belongs to the technical field of biomedicine. According to the method, firstly, embryonic stem cells or induced pluripotent stem cells are cultured and differentiated into three-dimensional brain organs, then an electric field device is used for conducting stimulation intervention in the development process of the brain organs, the structural change of the three-dimensional brain organs is detected, and it is proved that non-contact electric field stimulation promotes the maturity of the brain organs to be improved; in addition, the effect of non-contact electric field stimulation on the culture of the human MECP2 knockout Rater's syndrome brain organ disease model is researched, a reliable and effective in-vitro research model is provided for studying the nervous system development process, and a new way is provided for studying the treatment of diseases such as the Rater's syndrome related to the nervous development.