3 results about "Developing nervous system" patented technology

The invention relates to the technical field of medical diagnosis, and discloses a fetal nervous system auxiliary diagnosis method based on big data. The method comprises the following steps: collecting nervous system monitoring data of a plurality of fetuses; performing prenatal whole pregnancy dynamic tracking regularization processing on the ultrasonic radio frequency signal sequence, aligning ultrasonic characteristic differences among different fetuses, and generating a fetal nervous system development ultrasonic characteristic dynamic change curve; obtaining a non-pathological feature weight and an optimized association degree quantity of each sampling point, calculating a comprehensive importance score of each sampling point based on a product of the non-pathological feature weight and the optimized association degree quantity, and selecting the sampling points of which the scores are higher than a dynamic threshold value as key feature points; integrating amplitude data and clinical health scores of the regularized feature dynamic change curves of all fetuses at key feature points, and training a diagnosis prediction model by using a gradient boosting decision tree algorithm; and processing the ultrasonic radio frequency signal sequence of the fetus by using the diagnosis prediction model, extracting the amplitude of the key feature points, inputting the amplitude into the model, and outputting a nervous system development outcome risk prediction evaluation value.

A method for treating or reducing the severity of neurodevelopmental defects in a developing nervous system after exposure to an anesthetic by modulating or inhibiting caspase activity, for example, by administering a pan-caspase inhibitor such as pan-caspase inhibitor Q-VD-OPh to a subject having or at risk of congestive heart disease and / or having a ciliopathic disorder.

The invention discloses an MXene / enzyme modified acetylcholine nano microelectrode and application of the MXene / enzyme modified acetylcholine nano microelectrode in analysis of acetylcholine released by a single vesicle. The MXene / enzyme modified acetylcholine nano microelectrode constructed by the invention is used for analysis of acetylcholine released by the single vesicle. The method sequentially comprises the following steps: construction of an acetylcholine nano microelectrode, preparation of an acetylcholine artificial vesicle, extraction and culture of mouse primary cholinergic neurons, and release detection of acetylcholine in a single vesicle. A new thought and a new method are provided for monitoring the release condition of the acetylcholine single vesicles at the single cell level, and the method has important significance in studying nervous system development, understanding the physiological and pathological processes of nervous system diseases and regulating rules in treatment.