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Saliva polypeptide group AD biomarker

A biomarker, saliva technology, applied in instruments, measuring devices, scientific instruments, etc., can solve problems such as changes in test results, false negatives, etc.

Inactive Publication Date: 2019-11-01
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a salivary polypeptide group AD biomarker, which aims to solve the problem of false negatives that may be caused by changes in the application test results of the existing AD biomarkers, and improve the accuracy of the biomarkers. reliability

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  • Saliva polypeptide group AD biomarker

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Embodiment Construction

[0016] The present invention provides a salivary polypeptide group AD biomarker. In order to make the purpose, technical scheme and effect of the present invention more clear and definite, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0017] The present invention provides a salivary polypeptide group AD biomarker, wherein, the salivary polypeptide group AD biomarker includes histones, inflammatory proteins, energy metabolism proteins and proteins related to cytoskeleton and nervous system development.

[0018] In some embodiments, the histones include one or more of Histone H2A, Histone H3.2, Histone H1.3, Histone H2B type 1-J, Histone H3.1t, Histone H1.4, and Histone H4 . The histone is not only a model molecule of disease damage, but also a component of epigenetic regulation of the occurrence of AD and ...

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Abstract

The invention discloses a saliva polypeptide group AD biomarker. The saliva polypeptide group AD biomarker comprises a histone, an inflammatory protein, an energy metabolism protein and cytoskeleton and nervous system development-related proteins. According to the scheme of the invention, the histone, the inflammatory protein, the energy metabolism protein and the cytoskeleton and nervous system development-related proteins can be used as biomarkers of AD; the histone, the inflammatory protein, the energy metabolism protein and the cytoskeleton and nervous system development-related proteins are all simple and non-invasive saliva polypeptide group AD biomarkers, and can achieve more than 80% specificity and sensitivity to AD; and by adopting the saliva polypeptide group AD biomarker as anAD detection kit, whether a patient suffers AD can be quickly and effectively predicted, so that the intervention and delay of potential AD can be achieved.

Description

technical field [0001] The invention relates to the technical field of AD biomarkers, in particular to a salivary polypeptide group AD biomarker. Background technique [0002] As the most common type of Alzheimer's disease, Alzheimer's disease (AD) is a neurodegenerative disease caused by the death of nerve cells in the brain. It was first described by German psychiatrist and neuropathologist Alois Alzheimer in 1907 Named after the first report. Early diagnosis and intervention are the most effective ways to delay the occurrence of AD, and are of great significance to improving the quality of life of individuals and families and relieving the pressure of China's entry into an aging society. Neuropsychological scales, imaging, and biomarkers are the three main approaches to diagnosing AD. Biomarkers are substances (proteins, peptides, lipids or metabolites) that can predict or reflect changes in specific biological processes. AD disease may occur many years before cognitive...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N33/6848
Inventor 王勇程思明李水明倪嘉缵
Owner SHENZHEN UNIV
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