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Application of lncRNA (long noncoding RNA) TUNAR to regulation of cerebral nervous system development

A brain nervous system and reagent technology, applied in the application field based on lncRNA, can solve problems such as unclear functions

Inactive Publication Date: 2017-11-28
陈梦麟 +4
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Problems solved by technology

The lincRNA TUNAR is evolutionarily conserved and shows a CNS-specific expression pattern, but its function is not clearly defined

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  • Application of lncRNA (long noncoding RNA) TUNAR to regulation of cerebral nervous system development
  • Application of lncRNA (long noncoding RNA) TUNAR to regulation of cerebral nervous system development
  • Application of lncRNA (long noncoding RNA) TUNAR to regulation of cerebral nervous system development

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Embodiment Construction

[0031] The technical solution of the present invention will be further described below in combination with experiments.

[0032] Identification and functional prediction of prognostic long noncoding RNA genes in nervous system development

[0033]1. In June 2016, from the GEO chip data of NCBI in the United States, the gene group data related to the development of the human nervous system was mined, a total of 60,000 pieces of human genome expression profile data. Through co-expression analysis, find out the gene group related to the relevant expression level: the inventor through the co-expression analysis of the expression profile of the GEO Affy chip, is to find the genes that have a positive correlation between the expression level and the gene TUNAR, for example, through the correlation function. The top 319 genes with positive regulatory correlation (corr>0.40) were found (Table 1).

[0034] Table 1. The 319 genes with the highest co-expression positive correlation of T...

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Abstract

The invention discloses an application of lncRNA (long noncoding RNA) TUNAR to regulation of cerebral nervous system development. Signaling pathways, such as a nervous system development pathway and the like closely related to nervous system development molecular functions, as well as 319 target genes, related to prognosis of nervous system development, of long noncoding TUNAR are predicted successfully through co-expression analysis on the basis of a GEO chip common data base of NCBI (National Center of Biotechnology Information) in the USA. Further, RNA-seq sequencing results show high expression of both TUNAR and related nervous system proteins in nervous system specimens, and the correlation is quite remarkable. On the basis of the discovery, the mechanism of TUNAR induced cerebral dysplasia is expected to be determined clearly, a molecular regulation network based on neural cell differentiation is established gradually, and a theoretical basis is provided for searching new targets of prevention and drug treatment of cerebral dysplasia.

Description

technical field [0001] The present invention relates to the application based on lncRNA, in particular to the application of lincRNA TUNAR in regulating the development of brain nervous system. Background technique [0002] Congenital Cerebral Dysplasia (Congenital Cerebral Dysplasia) is a heterogeneous disease, neonatal abnormal brain development, including abnormal cortical proliferation (abnormal cortical proliferation) and abnormal neuron migration (abnormal neuronal migration) [1] and so on Types of. [0003] Abnormalities of cortical proliferation are predominantly manifested by microcephaly, which is associated with neurologic abnormalities and mental retardation [2]. The diagnosis is based on the measurement of the head circumference at the level of the skull base, and the diagnostic standard is less than 3 SD above the mean. The incidence rate is about 1.6 per 1000 single births, and only 14% of the small heads detected at birth are diagnosed as microcephaly withi...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68A61K45/00A61P25/00
CPCC12Q1/6883A61K45/00C12Q2600/136C12Q2600/158
Inventor 陈梦麟陈敏张楠黄凯铃骆颖筠刘艳卉陈卓娜史晓舜乐小兵
Owner 陈梦麟
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