4 results about "Neural cell differentiation" patented technology

The invention relates to the technical field of nerve cell differentiation, and discloses a culture medium for promoting neural differentiation of SH-SY5Y cells. The culture medium disclosed by the invention is prepared from the following components: tazarotene (tazarotene) and a basic culture medium. The culture medium can promote SH-SY5Y cells to present neuron-like differentiation within 5 days, significantly improves the length of neurite and the expression level of neuron markers, and is low in cytotoxicity. The invention provides an efficient, safe and standardized new tool for neural disease in-vitro model construction, drug screening and mechanism research.

The invention discloses a nutritional composition for synergistically regulating neural stem cells to differentiate into specific nerve cells. The invention provides a nutritional composition. The nutritional composition comprises the following necessary components: a grease component and a sialic acid oligosaccharide component, moreover, in the nutritional composition, the molar ratio of the grease component to the sialic acid oligosaccharide component is (1-5): (0.01-5). The nutritional composition provided by the invention can effectively promote the neural stem cells to differentiate into specific nerve cells and achieve function maturation, especially significantly promote the neural stem cells to differentiate into neurons, and shows a synergistic enhancement effect on the structure and function aspects, and the components have a synergistic effect.

The present invention provides a use of SQB-DNA nanostructures, prepared using DNA origami technology, for inducing differentiation into nerve cells or nerve cell regeneration, or treating nerve damage or neurological diseases. The present invention is the first instance of achieving nerve recovery through precise ligand presentation using DNA origami nanostructures, and the widespread use of SQB as a therapeutic drug for various types of nerve damage and neurological diseases requiring nerve regeneration is expected due to the provision of the present invention.

The application discloses a nerve regeneration guide conduit for promoting nerve cell differentiation and a preparation method and application thereof. The nerve regeneration guide conduit can realize stable and long-acting release of bioactive factors, effectively reduce the risk of tissue adhesion, efficiently induce nerve cell differentiation, promote axon growth and function recovery, and provides a novel and effective solution for nerve regeneration and repair. In addition, the nerve regeneration guide conduit has excellent conductivity, biocompatibility, mechanical adaptability and the like, and therefore has a wide application prospect in the field of nerve regeneration and repair.