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Glossy ganoderma extract and preparation method and use thereof

A technology of Ganoderma lucidum extract and extract solution, which is applied in the preparation of medicines. In the field of fat-soluble extract of Ganoderma lucidum spore powder, it can solve the problems of controversial clinical efficacy and high price, and achieve low cost, simple preparation process, and cell The differentiation-promoting effect of

Inactive Publication Date: 2009-09-23
苏州中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, if these neurotrophic factors are derived from animal bodies, they are expensive, and if they are genetically engineered products, their clinical efficacy is still controversial

Method used

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  • Glossy ganoderma extract and preparation method and use thereof
  • Glossy ganoderma extract and preparation method and use thereof
  • Glossy ganoderma extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of Ganoderma lucidum extract:

[0038] Using Ganoderma lucidum broken spore powder as raw material, first reflux and degrease with petroleum ether (60-90°C) for 2 times, each time for 30 minutes, the degreased spore powder evaporates until there is no ether smell; Extract 3 times, half an hour each time, combine the extracts, recover the ethanol to extract, and obtain the ganoderma lucidum extract.

[0039] Effect test on cell differentiation:

[0040] Nerve growth factor (NGF) is one of the important neurotrophic factors in the body. It can promote the development and differentiation of the central and peripheral nervous systems, maintain the normal function of the nervous system, and accelerate the repair of the nervous system after injury. Current research shows that when central cholinergic neurons and some motor neurons are injured (hypoxia, neurotoxicity, virus infection, mechanical injury), NGF can provide protection, reduce the degree of injury, and...

Embodiment 2

[0059] Preparation of Ganoderma lucidum extract:

[0060] Using Ganoderma lucidum broken spore powder as raw material, first reflux and degrease with petroleum ether (60-90°C) for 2 times, each time for 30 minutes, the degreased spore powder evaporates until there is no ether smell; Extract 3 times, half an hour each time, combine the extracts, recover ethanol until it is in the form of an extract; mix in diatomaceous earth at a ratio of 1:1 between diatomaceous earth and extract, and evaporate to dryness under reduced pressure at 60°C until there is no alcohol smell Ultrasonic extraction with 5 times the amount of chloroform for 3 times, and recovery of chloroform; ultrasonic extraction with 5 times the amount of ethyl acetate for 3 times, combining the extracts, recovering the solvent under reduced pressure to dryness, and obtaining the powder of Ganoderma lucidum extract.

[0061] The Ganoderma lucidum extract obtained in this example was compared with NGF.

[0062] attach...

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Abstract

The invention discloses a ganoderma lucidum extract, a preparation method and application thereof. The Ganoderma lucidum extract can be prepared by the following method: taking the broken spore powder of Ganoderma lucidum as raw material, degreasing with petroleum ether, and volatilizing until there is no ether smell; refluxing the obtained powder with ethanol for extraction, and concentrating the extract to extract. Further, the obtained extract can be made into powder, and the solid matter extracted with chloroform is then extracted with ethyl acetate, and the extract is recovered under reduced pressure and dried to obtain powdered Ganoderma lucidum extract. The extract can effectively induce nerve cell differentiation, and can be used for preparing medicines for treating nerve injury and neurodegeneration.

Description

technical field [0001] The invention relates to a Ganoderma lucidum extract, in particular to a fat-soluble extract of Ganoderma lucidum spore powder, and also relates to a preparation method of the extract and its application in preparing medicines. Background technique [0002] Ganoderma lucidum is a basidiomycete polyporaceae Ganoderma plant, and its growth process includes three stages: fruiting body, mycelium and spore powder. Ganoderma lucidum has been considered as an effective tonic and strong medicine since ancient times, and the most widely used is the fruiting body of Ganoderma lucidum. Studies have shown that the main chemical components of Ganoderma lucidum are polysaccharides, nucleosides, triterpene acids, sterols, biological Alkalis and amino acids, etc., have a wide range of effects in many aspects such as sedation, cardiac strengthening, anti-aging, improving the body's ability to withstand hypoxia, anti-fatigue, and anti-tumor. Therefore, it is used to pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/074A61K9/14A61P25/08A61P25/14A61P25/16A61P25/00
Inventor 秦正红张丽彭少平顾振纶
Owner 苏州中药研究所有限公司
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