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Application of pomegranate peel in preparation of medicine for promoting bone marrow mesenchymal stem cell migration, medicine and preparation method thereof

A bone marrow mesenchymal and stem cell technology, applied in the field of medicine, can solve problems such as low migration rate and achieve the effect of promoting expression

Active Publication Date: 2021-05-18
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a kind of application of pomegranate peel in the preparation of promoting the migration of bone marrow mesenchymal stem cells, the medicine and its preparation method, which aims to effectively induce the migration and differentiation of bone marrow mesenchymal stem cells to the lesion tissue. Drugs to Improve Efficacy to Address Low Migration in Bone Marrow Mesenchymal Stem Cell Transplantation

Method used

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  • Application of pomegranate peel in preparation of medicine for promoting bone marrow mesenchymal stem cell migration, medicine and preparation method thereof
  • Application of pomegranate peel in preparation of medicine for promoting bone marrow mesenchymal stem cell migration, medicine and preparation method thereof
  • Application of pomegranate peel in preparation of medicine for promoting bone marrow mesenchymal stem cell migration, medicine and preparation method thereof

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preparation example Construction

[0044] A preparation method of a medicine for promoting migration of bone marrow mesenchymal stem cells, comprising: soaking pomegranate peels in an aqueous solution for 2-3 hours, decocting the solution soaked in pomegranate peels for 30-50 minutes, and then filtering.

[0045] Further, the ratio of the pomegranate peel to the aqueous solution is 1:15-20.

[0046] Further, after decocting the solution soaked with pomegranate peels for 30-50 minutes, water is added to the decocted mixture, decocted and then filtered.

[0047] Specifically, the preparation method in this example is as follows: Weigh 50 g of the dried pomegranate peel raw material, soak it in distilled water for 2 hours in a 1000 mL beaker (the liquid surface submerges the medicinal material by about 3 cm). Decoct twice, add 400ml of water each time; decoct for 30 minutes, filter through gauze to remove slag, combine the filtrate, continue heating and concentrating the total decoction to 476.5mL, and obtain pome...

Embodiment 1

[0050] This embodiment provides a kind of medicine, and this medicine is made by following preparation method:

[0051] Weigh 50g of the dried pomegranate peel raw material, soak it in distilled water for 2h in a 1000mL beaker (the liquid surface submerges the medicinal material by about 3cm). Decoct twice, add 400ml of water each time; decoct for 30 minutes, filter through gauze to remove slag, combine the filtrate, continue heating and concentrating the total decoction to 476.5mL, and obtain pomegranate peel with a crude drug content of 0.105g / ml Water decoction, store in the refrigerator at 4°C for later use. Warm up to 25°C in a water bath.

Embodiment 2

[0053] This embodiment provides a kind of medicine, and this medicine is made by following preparation method:

[0054] Weigh 50g of dried pomegranate peel raw material and soak it in distilled water for 3h in a 750mL beaker. Boil the solution soaked with pomegranate peel for 50 minutes and then filter. Heat and concentrate the filtrate to 476.5mL to obtain a water decoction of pomegranate peel with a crude drug content of 0.105g / ml, and store it in the refrigerator at 4°C for later use. Warm up to 25°C in a water bath.

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Abstract

The invention relates to the field of medicines, in particular to the application of pomegranate peel in preparing medicines for promoting the migration of bone marrow mesenchymal stem cells, medicines and preparation methods thereof. Application of pomegranate peel in preparation of medicine for promoting migration of bone marrow mesenchymal stem cells. A drug for promoting migration of bone marrow mesenchymal stem cells, the raw material of which includes pomegranate peel. A preparation method of a medicine for promoting the migration of bone marrow mesenchymal stem cells, comprising: soaking pomegranate peels in an aqueous solution for 2-3 hours, decocting the solution soaked in pomegranate peels for 30-50 minutes, and then filtering. Pomegranate peel or pomegranate peel water decoction can effectively induce bone marrow mesenchymal stem cells to migrate and differentiate into diseased tissues, and at the same time, pomegranate peel or pomegranate peel water decoction can promote the expression of SDF‑1 protein.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of pomegranate peel in preparing medicines for promoting the migration of bone marrow mesenchymal stem cells, medicines and preparation methods thereof. Background technique [0002] Bone marrow mesenchymal stem cells (mesenchymal stem cells, MSCs) is one of the stem cells with the most research and application potential, and is an ideal model for studying the mechanism of proliferation and differentiation. However, the content of MSCs in the bone marrow is very small, and clinical administration is usually administered by intravenous injection. Therefore, after intravenous administration, the amount of stem cells migrating and homing to the damaged tissue becomes an important factor affecting the efficacy of stem cells. Numerous animal experiments, clinical experiments, and cell experiments have shown that the migration and homing ability of transplanted MSCs is not enou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K35/28A61P1/04
CPCA61K35/28A61K36/185A61K2236/331A61K2236/39A61K2300/00
Inventor 宋小莉胡亚洁郑志娟刘慧敏杨莹闫宾雒岁芳
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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