68results about How to "Effective intake" patented technology

The invention relates to a mixed drilling bit with an enhanced core part cutting function used for petroleum, natural gas and geology drilling. The mixed drilling bit comprises a drilling bit body, wherein cutter wings and a spray nozzle are arranged on the drilling bit body, the outline of the cutter wings is divided into a core part, an inner cone, a nose part, a shoulder part and a diameter maintaining part from inside to outside, fixed cutting teeth are arranged at the inner cone, the nose part, the shoulder part and the diameter maintaining part of the outline of the cutter wings on the cutter wings, a tooth palm is arranged between the cutter wings, the upper end of the tooth palm is connected into a whole with the drill bit body, the lower end of the tooth palm is provided with a tooth wheel, and tooth wheel cutting teeth are arranged on the tooth wheel. The mixed drilling bit is characterized in that the core part of the lower end of the drilling bit body is provided with the movable cutting teeth. The mixed drilling bit has strong integral performance, and shaft bottom rock can be effectively subjected to pre-crushing, so the fixed cutting teeth of the drilling bit can effectively enter the rock, in addition, the impact on the fixed cutting teeth can be reduced, the cutting efficiency and the mechanical drilling speed of the core part of the drilling bit can be respectively improved and accelerated, and the integral cutting efficiency and the mechanical drilling speed can be respectively improved and accelerated.

The invention relates to a hybrid drill bit for petroleum, natural gas and geological drilling. The hybrid drill bit comprises a drill bit body, wherein a cutter wing and a roller cone are arranged on the drill bit body, cutting teeth are arranged on the cutter wing, the roller cone is connected with the drill bit body through a cone leg, and the hybrid drill bit is characterized in that the roller cone is a disk type roller cone. A cutting element on the disk type roller cone is shaped like a disk cutter or an intermittent disk cutter. The patent disclosed by the invention has the beneficial effects that, 1) the scraping motion of a diamond drill bit and the rolling motion of a disk type roller cone drill bit are combined for realizing precrushing at the bottom of a well, thereby ensuring that the diamond cutting teeth can effectively bite rock, eliminating the stick-slip phenomenon of the drill bit in some special formations and the probability of impact disrepair of a polycrystalline diamond compact (PDC) and improving the cutting efficiency and the mechanical drilling speed of the drill bit; and 2) the disk type roller cone can realize the precrushing of a rock layer at the bottom of the well more steadily, reduce the impact on the PDC, enhance the stability in drilling of the drill bit and enable the drill bit to realize faster and more stable drilling.

The present invention relates to food producing technology, and is especially making process of fermented plant fiber and protein food. The fermented plant fiber and protein food is made with soybean, peanut, coffee bean, rape, nut and / or nut residue containing plant fiber and protein as material, and through regulating water content to 60-85 %, cooking, fermenting through inoculating some bacterial seed, crushing the fermented product, seasoning and further treating to obtain different types of fermented plant fiber and protein food. The process is simple and feasible, and the food product has complementary and easy-to-absorb nutrients.

The invention discloses a disc cutter type multiple drill bit suitable for a hard-to-drill stratum. The disc cutter type multiple drill bit comprises a drill bit body, a plurality of cutter wings extending to the drill bit body, a disc cutter rotatably connected relatively to the drill bit body, and a water hole or a nozzle formed in the drill bit body; a plurality of first groups of cutting teeth are formed in the cutter wings, a slot is formed in the tooth surface of the cutter wing to fix the first group of cutting teeth, the disc cutter comprises a disc cutter body and disc cutter teeth arranged on the disc cutter body, the contour line of a body of at least one cutter wing and the contour line of a body of at least another cutter wing have at least one mismatched area in the common coverage area and at least one matched point or matched area. The structural feature enables the drill bit to work in an asynchronous cutting manner, so that the longitudinal abrasion length of the drill bit is increased, the service life of the drill bit is prolonged, in addition, the drill bit is kept in a high specific pressure drilling state in the whole drilling process, and the capability of the drill bit drilling in a rock is strengthened. Therefore, and the drilling speed and the service life of the drill bit in the hard-to-drill stratum are increased and prolonged.

The invention relates to a DCs vaccine based on phospholipid hybrid polymersome jointly encapsulating an antigen and dual immunoagonists, a preparation method and application thereof. The phospholipidhybrid polymersome which can jointly load a model antigen OVA and two types of TLR agonists (TLR7 / 8 and TLR4) is used for stimulation in vitro of the DCs so as to realize the effective phagocytosis of DCs cells. The rapid and long-term immunostimulatory effect on the DCs is achieved by the internal and external co-loading of the OVA antigen. The synergistic effect of the two types of TLR agonistssignificantly enhances the immune response after antigen stimulation; the phospholipid hybrid polymersome which jointly encapsulates the antigen and the dual immunoagonists can effectively promote the activation and maturation of the DCs, increases the level of cross-presentation, promotes the migration of the DC vaccine to secondary lymphoid organs, and produces a strong specific cytotoxic T lymphocytes (CTLs) killing effect, thereby effectively killing tumor cells and realizing the immunotherapy of the DCs vaccine on tumors.

The invention discloses a magnetic nanoparticle of a layer-by-layer wrapping structure and a preparation method and application thereof.The magnetic nanoparticle is composed of an inner core, a middle layer and an outer layer, wherein the inner core and the middle layer are combined and the middle layer and the outer layer are combined by means of the electrostatic attraction effect, the inner core is a ferroferric oxide nanoparticle modified by a cationic polymer, the middle layer is a to-be-transfected gene wrapping the outside of the inner core, and the outer layer is a spermine and Pulullan copolymer wrapping the outside of the middle layer.According to the magnetic nanoparticle, the to-be-transfected gene is combined with the inner core first and then combined with the spermine and Pulullan copolymer, and therefore the to-be-transfected gene is tightly wrapped by the magnetic nanoparticle and prevented from being degraded in the transfection process; spermine and Pulullan can be recognized and absorbed by mesenchymal stem cells, and the cell entering efficiency of the magnetic nanoparticle is further improved; the spermine and Pulullan copolymer has little toxicity to mesenchymal stem cells, and the safety risks caused by transfection to stem cells are effectively reduced.

The invention discloses a punching composite drill bit suitable for difficult-to-drill stratums. The drill bit comprises a drill bit body, blades and water holes or nozzles arranged in the drill bit body, wherein each blade is provided with a plurality of first cutting teeth, the tooth arranging face of each blade is provided with sockets for fixing the first cutting teeth, the drill bit body is further provided with punching structures and an impact force transmission mechanism, the punching structures are provided with punching teeth, and the body contour line of at least one blade and the body contour line of at least another blade are provided with at least one non-overlap area and at least one overlap point or area in a joint covering area. By the structure, the drill bit can work in an asynchronous cutting manner, the longitudinal abrasion length of the drill bit can be increased, the service life of the drill bit can be prolonged, the drill bit can be allowed to be in a high-specific-pressure drilling state during the whole drilling process, the rock drilling ability of the drill bit is enhanced, the drilling speed of the drill bit in the difficult-to-drill stratums is increased, and the service life of the drill bit in the difficult-to-drill stratums is prolonged.

The invention discloses an oral vaccine delivery system. W1 of W1 / O / W2 type nanoparticles is a vaccine medicine phase, an organic phase O is selected from PLGA and HP55, an external water phase W2 and a continuous water phase are selected from poloxamer 188, and a vaccine medicine is a double epitope-double adjuvant helicobacter pylori vaccine. The method adopts a polymer material having good biological safety and good compatibility to prepare the nanoparticles, a preparation process and a formula are optimized, the oral vaccine delivery system is non-toxic, free of any side effects, easy to manufacture and low in cost. In the field of biological medicines, the nanoparticles can be used for oral taking of a helicobacter pylori subunit vaccine, accordingly helicobacter pylori infection related diseases are prevented and treated, and huge economic benefits and social benefits are brought.

The invention discloses a reaming drill bit with a long service life for strata difficult to drill. The reaming drill bit comprises a drill bit body and a plurality of blades. The drill bit body comprises a pilot body and a reaming body; the blades extend from the pilot body and the reaming body, water holes are formed in flow channels among the blades, or spray nozzles are arranged in the flow channels among the blades, a plurality of first groups of cutting teeth are arranged on the blades, pits are formed in tooth distribution surfaces of the blades and are used for fixing the first groups of cutting teeth, and contour lines of bodies of the blades of at least two pilot sections and / or at least two reaming sections have non-coincidence regions and coincidence points or coincidence regions. The reaming drill bit with structural characteristics has the advantages that the reaming drill bit can work in asynchronous cutting modes, the abrasive lengths of the blades can be increased, and the service life of the reaming drill bit can be prolonged; the reaming drill bit can be in high-specific-pressure drilling states in integral drilling procedures, the rock intrusion capacity of the reaming drill bit can be enhanced, accordingly, the drilling speeds of the reaming drill bit in the strata difficult to drill can be increased, and the service life of the reaming drill bit in the strata difficult to drill can be prolonged.

The invention discloses an additive premix for stereo cultivation of Tilapia mossambica as well as a preparation method and a use method thereof. The premix comprises a material A which is prepared from vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B16, DL-calcium pantothenate, niacin, folic acid, inositol, 2% biotin, 35% vitamin C, an antioxidant, bacillus subtillis, a mildew preventive, immunopolysaccharide, bile acid and defatted rice bran; the premix which is prepared from the following components such as vital cobalt, copper sulfate pentahydrate, ferrous sulfate, magnesium sulfate, manganese sulfate, zinc sulfate, sodium selenite, choline chloride, an acidifier, calcium dihydrogenphosphate, table salt, garlicin, kelp powder, zeolite powder and the like is added into Tilapia mossambica feed in proportion. Various special components are added to satisfy the demand of Tilapia mossambica on components of vitamins or mineral elements under the stereo cultivation condition, so that the immunity of Tilapia mossambica can be effectively improved and the incidence of Tilapia mossambica under severe environments can be reduced.

One kind of beverage is prepared, which includes ester type catechin (A), free catechin (B) and caffeine (C) in the amount of A+B=500-6000 mg / L, A / (A+B)=0.7-1.0, and A / C=6-27. The beverage has high concentration of catechin with high biological function, improved flavor and improved quality, especially improved precipitation performance.

The invention belongs to the technical field of microorganisms and particularly relates to high-conversion-rate bacillus subtilis and preparation and application thereof. The problem that the bacillus subtilis A164 is low in conversion efficiency is solved through a plasmid expression method, then a linear fragment containing a comk expression cassette is integrated on an A164 genome through an induced conversion method, and resistance is eliminated by the aid of a cre / lox specific recombination system to obtain bacillus subtilis A164S which is free of resistance marker, easy to operate and high in conversion efficiency and secretion capability. Research results show that conversion efficiency of the bacillus subtilis A164S is more than 1000 times of that of the bacillus subtilis A164; the bacillus subtilis A164S can effectively take in homologous DNA, can efficiently secrete heterologous proteins, and has high application potential in recombinant expression of exogenous genes.

The invention provides a fancy fish dosing device and dosing method. The device comprises a fishing device and a dosing bottle. The fishing device is provided with a fish inlet ring and a size-adjustable fish outlet ring. The fish inlet ring and the fish outlet ring are connected via a mesh sleeve. Multiple non-return bands, which extend to the center and bend into the fishing device under the effect of external force, are evenly arranged on the fish inlet ring. The fish inlet ring or the fish outlet ring is provided with a handle. The dosing bottle comprises a bottle body and a bottle cap which is matched with the bottle body. The bottle body is an elastic bottle body made of elastic material. A flexible conduit is connected on the bottle cap. The fishing device is reasonable in design and convenient for catching fishes under dosing, and the fish outlet ring can be adjusted according to the size of the fishes so that practicality is high. According to the fancy fish dosing method, pertinence of fancy fish disease treatment can be enhanced, medicine effect can be enhanced, waste can be reduced, pollution can be lowered and environmental protection can be enhanced so as to be simple and rapid.

The invention relates to a food formula and a processing method, and especially relates to a formula and a processing method of tea dumplings. The method comprises the following steps: picking and disinfecting fresh tea, performing enzyme deactivation and processing, preparing a wrapper material by 10 parts of tea powder and 400 parts of flour, wherein the wrapper material has a tea green color; performing infusion of 50 parts of the processed tea with boiling water, washing the tea, cooling with cold water, performing dehydration, adding 500 parts of meat, 3 parts of table salt, 1 parts of edible sugar, 2 parts of ginger, 30 parts of edible oil, 1 parts of fermented bean curd as fillings. The formula and the processing method of tea dumplings of the invention mix the tea component with dumpling wrappers and fillings, which provides people with effective intake of various nutritional components in tea during daily eating of dumplings, reduces greasiness of the meat fillings, and is more beneficial to human diet health.

The invention discloses an orthoester 5-fluorouracil prodrug molecule. The orthoester 5-fluorouracil prodrug molecule is N-5-fluorouracil1-ethyl-2-carbonalkoxy-(1,3) dioxolane-4-methylformamide havinga structure as shown in formula (I) described in the specification, wherein n=2-32 and m=n+2. The invention further discloses a preparation method of the abovementioned prodrug molecule and a nanoparticle prepared therefrom and an application thereof. The orthoester 5-fluorouracil prodrug molecule, the preparation method and the nanoparticle and the application thereof have the advantages that the nanoparticle prepared by the orthoester 5-fluorouracil prodrug molecule not only has the advantages of a small molecule prodrug but also is endowed with the advantage of a nano drug delivery system(that is a drug carrier), the prodrug nanoparticle not only has excellent acid degradation property and reduced tumor cytotoxicity and realizes passive targeting enrichment of a drug in a tumor, the nanoparticle has high drug loading capacity because the drug is used as a main part of the carrier, and the nanoparticle is capable of loading other antitumor drugs and achieves the effect of cooperatively treating the tumor and thus has good application prospects in the field of tumor treatment.

The invention discloses a composite drill bit with a roller cone arranged on a tool blade. The composite drill bit comprises a drill bit body, wherein the fixed tool blade and a spray nozzle are arranged on the drill bit body; fixed cutting teeth and the roller cone are arranged on the fixed tool blade; cone roller cutting teeth are arranged on the roller cone. The composite drill bit with the roller cone arranged on the tool blade has the advantages that rock is impacted and pre-crushed by the roller cone cutting teeth, and the fixed cutting teeth on the fixed tool blade are assisted to effectively enter the rock; by arranging the roller cone on the tool blade, the space utilization rate of the composite drill bit is increased, jaws are not used, manufacturing technological steps are reduced, the assembly error is reduced, and the quality of the drill bit is improved.

The invention relates to a PDC drill bit with module cutting teeth. The PDC drill bit comprises a drill bit body (1) and a drill bit joint (2) arranged at one end of the drill bit body (1); multiple main blades (3) and multiple secondary blades (4) are arranged at the other end of the drill bit body (1) at intervals; multiple main cutting teeth are respectively arranged on the nose parts and the side surfaces of the main blades (3) and the secondary blades (4); the main cutting teeth comprise wear-resisting module cutting teeth (7) and impact-resisting module cutting teeth (8), wherein the wear-resisting module cutting teeth (7) and the impact-resisting module cutting teeth (8) are of cylindrical structures, the wear-resisting module cutting teeth (7) are composed of a base A (9) and a composite sheet A (10), and the impact-resisting module cutting teeth (8) are composed of a base B (11) and a composite sheet B (12). The PDC drill bit disclosed by the invention has the advantages that the high drilling speed can be maintained, and the long service life is guaranteed, the PDC drill bit is especially suitable for the drilling operation of the complex and abrasiveness stratum.

The invention relates to a method for detecting the content of vitamin C in fruits, which comprises the following steps: detecting the content of the vitamin C in various fruits by titration; dividingthe fruits into three classes according to the content; and analyzing the growing environment of each class of fruits and the activity state of the vitamin C. Compared with the prior art, the methodfor detecting the content of the vitamin C in the fruits has the characteristics of simplicity, convenience, low price and the like.

The invention provides a nano-composite and a preparation method and application thereof. The raw materials of the nano-composite include Imatinib, pegylated polymer and mannose-modified chitosan oligosaccharide, wherein the outer layer of the nano-composite is wrapped by the mannose-modified chitosan oligosaccharide, Imatinib is wrapped and loaded by the pegylated polymer as a carrier inside thenano-composite, and the mass ratio of the pegylated polymer raw material to Imatinib is (8-50):1. The nano-composite can be taken in effectively by macrophages, M2-type differentiation of the macrophages can be blocked, M1-type differentiation of the macrophages is promoted, and the activity of the macrophages is improved, so that the survival time of immunosuppression-state mice which are infected with acute invasive fungi is prolonged, and the purpose of resistance to fungal infection is achieved.

The invention discloses a cigarette appearance defect visual detection system and a detection method thereof. The cigarette appearance defect visual detection system comprises an image acquisition module, an image processing module, a controller module and a rejecting module, and is characterized in that the difference between a target and the background is obtained clearly by arrangement of a light source, the good light source can effectively take in information and reduce interference, and through an AI algorithm, two-stage detection is carried out on the defects of the cigarette, the detection accuracy is greatly improved, two CCD cameras are used for collecting images of the outer surface of the cigarette, an advanced image analysis processing algorithm is used, the defects on the surface of the cigarette can be accurately analyzed and detected, and the defect type is distinguished through the AI algorithm, if the cigarette is abnormal, an alarm can be prompted or a machine can becontrolled to stop, and cigarettes which do not meet requirements can be rejected after being detected. According to the system, the labor intensity of the detection personnel can be effectively reduced, the detected products can be finely classified, the product quality can be improved, and the actual production can be guided by utilizing big data.

The invention provides a manufacturing method of a soybean milk-like drink and a soybean curd, and an airstream grinding device to use for the manufacturing method, wherein the soybean milk-like drink and the soybean which are rich in healthy functional components, flavor and mouth feel can be manufactured through a simple equipment structure in a low-power, low-cost and short-time manner. The manufacturing method comprises the following steps: a blank hypocotyl powder preparing step with the procedures of drying raw soybeans, peeling, taking out the hypocotyls, heating the hypocotyls, performing air current crushing on the hypocotyls at a temperature below 55 DEG C, fine-crushing to hypocotyl powders of which the median diameter (d50) is 20-40 mu m and the proportion of the powders with diameter below 100 mu m is higher than 90%; a soybean powder preparing step of performing air current crushing on the soybeans without hypocotyls, and fine-crushing to soybean powders of which the median diameter (d50) is 20-40 mu m and furthermore the proportion of the powders with diameter below 100 mu m is higher than 90%; and a raw material mixing step of mixing 0.05-2wt% of the hypocotyl powder and 2-22wt% of the soybean powders, thereby preparing the soybean milk-like drink.

The invention discloses a composite biological preparation for treating domestic sludge, a preparation method and a treatment method thereof. The composite biological preparation comprises: alcaligenes, arthrobacter, and stenotrophomonas maltophilia; wherein the weight ratio of alcaligenes, arthrobacter, and stenotrophomonas maltophilia is 22-26: 15-20:10-14. The method combines specific strains together, and can effectively decompose organic substances in the sludge after being treated for a certain period of time under normal temperature conditions, and stabilizes the sludge after standing for a certain period of time, which can effectively remove ammonia and H2S from the sludge, removes the foul odor in the sludge, and releases most of the moisture in the sludge in a short time, the treated sludge can be used as a soil amendment, an organic fertilizer, and the like, can be directly used for planting crops without affecting the growth and development of crops, and does not affect thequality of crops.

The invention relates to a mixed drilling bit with an enhanced core part cutting function used for petroleum, natural gas and geology drilling. The mixed drilling bit comprises a drilling bit body, wherein cutter wings and a spray nozzle are arranged on the drilling bit body, the outline of the cutter wings is divided into a core part, an inner cone, a nose part, a shoulder part and a diameter maintaining part from inside to outside, fixed cutting teeth are arranged at the inner cone, the nose part, the shoulder part and the diameter maintaining part of the outline of the cutter wings on the cutter wings, a tooth palm is arranged between the cutter wings, the upper end of the tooth palm is connected into a whole with the drill bit body, the lower end of the tooth palm is provided with a tooth wheel, and tooth wheel cutting teeth are arranged on the tooth wheel. The mixed drilling bit is characterized in that the core part of the lower end of the drilling bit body is provided with the movable cutting teeth. The mixed drilling bit has strong integral performance, and shaft bottom rock can be effectively subjected to pre-crushing, so the fixed cutting teeth of the drilling bit can effectively enter the rock, in addition, the impact on the fixed cutting teeth can be reduced, the cutting efficiency and the mechanical drilling speed of the core part of the drilling bit can be respectively improved and accelerated, and the integral cutting efficiency and the mechanical drilling speed can be respectively improved and accelerated.

The invention relates to a standard abrasion piece suitable for petroleum drilling stratum rock abrasivenesss detection. The standard abrasion piece is characterized by adopting a mini-type coring bit structure comprising a grinding component and a steel connecting component, wherein the grinding component comprises a phenolic resin base material and an artificial polycrystalline diamond grinding material; the standard abrasion piece is integrally formed via sintering according to a hot pressing technology, and is connected onto the spindle of a test device via the steel connecting component after being machined and trimmed. The standard abrasion piece has the benefits that the wear resisting property is reasonable; the self-sharpening property is excellent; rock can be drilled effectively; moreover, own abrasion of the standard abrasion piece reflects the abrasion of a diamond bit during a practical well drilling process; the structural is small and exquisite; the matched test device is simple; the operation is convenient; the technical conditions are stable; the consumption of a test rock sample or an on-site rock core can be greatly reduced under the condition that simulation requirements of a diamond bit dynamic grinding rock breaking process are met, and test cost is reduced.

The invention relates to an apparatus of a treatment system for southern rural domestic sewage and a method used by the same. The apparatus comprises a system I and a system II; the system I comprises an influent distribution pipe, an upper gravel layer, a river sand layer, a waterproof non-woven fabric, a lower gravel layer, an anti-blocking water-collecting groove and a wetland plant A; the system II comprises an upper gravel layer, a system II river sand layer, a crushed rock layer, a lower gravel layer, a downstream effluent pipe, an upstream effluent pipe and a wetland plant B; detailed structure and method are described in the specification. The apparatus provided in the invention is designed based on the characteristics of domestic water quality and sewage discharge in southern rural areas, has simple process requirements, is convenient to operate and manage, does not need external electric power facilities, produces a good effect on treatment of domestic sewage and is suitablefor popularization and application in southern rural areas.

The invention discloses a magnetic targeting cell membrane modified ligand, a drug-loading material, a preparation method of the magnetic targeting cell membrane modified ligand and the drug-loading material and an application of the drug-loading material. The structural general formula of the magnetic targeting cell membrane modified ligand is shown as I series or II series in the formula (1). The magnetic targeting cell membrane drug-loading material is obtained by performing chemical covalent bond modification on a cell membrane to modify the magnetic targeting cell membrane modified ligand, an in-vitro test shows that the material is good in stability, can be effectively taken in by tumor cells, and has relatively high selectivity on the tumor cells, and besides, the material has remarkable paramagnetism. Under the condition of an external magnetic field, a magnetic targeting effect can be achieved. In an in-vitro anti-tumor test, the drug-loading material is remarkable in anti-tumor activity and hardly has toxicity to normal cells, so that the drug-loading material has a potential application of targeted therapy of malignant tumors.

The invention discloses a platinum sulfide protein nanoparticle with a near-infrared photothermal effect and a multi-mode imaging function as well as a preparation method and application of the platinum sulfide protein nanoparticle. By carrying out formulation screening and process limitation, the platinum sulfide protein nanoparticle with the near-infrared photothermal effect and the multi-mode imaging function is prepared in a water phase, has an ultra-small particle size and good stability, tumor targeting property and photothermal effect and is integrated with near-infrared imaging, CT imaging, photoacoustic imaging and thermal imaging functions, the high-sensitivity and high-resolution precise localization of tumors is realized, an efficient photothermal effect is generated under thestimulation of near-infrared light, tumor cells are killed through thermal ablation, and the efficient, safe, visual and accurate treatment of the tumors is realized; and the platinum sulfide proteinnanoparticle has potential to be further applied to the clinic.

The invention discloses a long-service-life drill bit suitable for difficult-to-drill stratums. The drill bit comprises a drill bit body and a plurality of blades extending from the drill bit body, wherein water holes or nozzles are arranged in runners among the blades, each blade is provided with a plurality of first cutting teeth, the tooth arranging face of each blade is provided with sockets for fixing the first cutting teeth, and the contour lines of at least two blades have both non-overlap areas and overlap points or areas. By the structure, the drill bit can work in an asynchronous cutting manner, the longitudinal abrasion length of the drill bit can be increased, the service life of the drill bit can be prolonged, the drill bit can be allowed to be in a high-specific-pressure drilling state during the whole drilling process, the rock drilling ability of the drill bit is enhanced, the drilling speed of the drill bit in the difficult-to-drill stratums is increased, and the service life of the drill bit in the difficult-to-drill stratums is prolonged.

The invention provides a pH-responsive mesoporous silicon nanoparticle treatment vaccine based on a co-entrapped antigen and a photosensitizer as well as a preparation method and an application thereof, and relates to the technical field of treatment vaccine; the inventor designs a nano platform, mesoporous silicon dioxide nanoparticles are used as a carrier, co-loaded photo-thermal treatment agent dopamine and sulfhydrylated antigen are used for photo-thermal combined immune treatment of tumors. According to the preparation method provided by the invention, the pH-responsive mesoporous silicon nanoparticle treatment vaccine based on the co-entrapped antigen and the photosensitizer is obtained, and the antigen entrapment rate is up to 92.20%. Meanwhile, the preparation method is simple inprocess, convenient to operate, capable of being achieved without expensive instruments or high-end technicians, low in cost and suitable for application and popularization.