5results about How to "Effective intake" patented technology

This invention belongs to the field of drilling equipment technology and discloses a PDC drill bit, including a body and multiple cutter wings. The body has flow holes for drilling fluid. Multiple cutter wings are spaced apart circumferentially on the body, and the cutter wings can slide relative to the body along its axial direction. The drilling fluid can drive the cutter wings to extend along the axial direction of the body. By enabling the cutter wings to move relative to the body along its axial direction, and by allowing the drilling fluid to drive the cutter wings to extend along the axial direction of the body, during drilling operations, the PDC drill bit drills into the formation under the drive of the drill pipe's drilling pressure. When the formation resistance experienced by the cutter wings is less than the driving force of the drilling fluid driving the cutter wings to extend, the cutter wings extend under the drive of the drilling fluid; when the formation resistance experienced by the cutter wings is greater than the driving force of the drilling fluid driving the cutter wings to extend, the cutter wings retract under the action of the formation. This allows each cutter wing of the PDC drill bit to automatically extend or retract according to its respective formation resistance, thereby effectively penetrating the formation.

This invention discloses carbon nanodots, their preparation method, and their applications, relating to the field of carbon nanomaterials technology. The carbon nanodots are prepared by solvothermal treatment of nicotinamide, urea, and citric acid or its derivatives. The citric acid derivative is selected from citrate, citric acid hydrate, or citrate hydrate. This invention synthesizes carbon nanodots using nicotinamide as a precursor under solvothermal treatment, simultaneously integrating intrinsic bioactivity, efficient photothermal conversion capability, and red fluorescence imaging function. This multifunctional synergistic therapy overcomes the limitations of single-therapy approaches. Furthermore, the carbon nanodots provided by this invention exhibit extremely high biocompatibility.

The invention relates to stem cell-derived engineered nano-vesicles (e-NVs) for promoting hair growth, the engineered nano-vesicles are prepared from stem cells through engineering induction, apoptosis induction and programmed serial extrusion processes in sequence, and an inducer used for engineering induction is 3, 3 '-diindolylmethane. The particle size of the engineered nano vesicle is mainly distributed in a range of 50-300 nm, the polydispersity coefficient is 0.05-0.20, and the expression proportion of phosphatidylserine is 40%-50%. The rice vesicles can effectively improve the hair follicle microenvironment, adjust the hair growth cycle, promote proliferation and differentiation of hair follicle stem cells and remarkably increase the hair regeneration rate of androgenetic alopecia model mice, and a safe, convenient and efficient clinical strategy is provided for hair regeneration treatment.

The utility model relates to a novel diamond brazing drill bit belongs to the drilling equipment technical field for geological exploration, technical scheme is: the end of steel body is equipped with a plurality of even arrangement's diamond cutting tool along the circumferential direction, and the space between two adjacent diamond cutting tools is water gap, and the cutting surface of diamond cutting tool end is arc lip face, the arc lip face is made of brazing binder inlaying diamond, and the diamond is inlaid in the inside and surface of brazing binder, the utility model has the following active effect: the top of diamond cutting tool is arc lip face, can guarantee that the drill bit effectively eats into the stratum and makes rock produce effective crushing, and can guarantee stability. The diamond is inlaid in the inside and surface of brazing binder, can realize the chemical metallurgical combination of diamond, Ni base binder and metal matrix interface, has higher bonding strength, and the diamond is not easy to fall off, can drill in any rock stratum, and overcomes the problem of low drilling efficiency.

The application discloses a glutamine transport inhibitor and a pharmaceutical composition and application thereof. The structure of the inhibitor is shown as formula I, and the inhibitor also comprises isomers, pharmaceutically acceptable salts or mixtures thereof. The inhibitor and the pharmaceutical composition thereof have ASCT2 inhibiting activity, can effectively inhibit tumor cell glutamine uptake, and realize the inhibiting effect on tumor cells. The application has wide application and can be prepared into a medicine for treating diseases related to ASCT2, and the medicine can exert the pharmacodynamic effect at the molecular level and the cell level. In addition, the compound preparation method is simple and easy to operate.