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Glossy ganoderma extract and preparation method and use thereof

A technology of Ganoderma lucidum extract and extract solution, which is applied in the preparation of medicines. In the field of fat-soluble extract of Ganoderma lucidum spore powder, it can solve the problems of high price and controversial clinical efficacy, and achieve low cost, induction of nerve cell differentiation, The effect of simple preparation process

Inactive Publication Date: 2005-07-06
苏州中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if these neurotrophic factors are derived from animal bodies, they are expensive, and if they are genetically engineered products, their clinical efficacy is still controversial

Method used

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  • Glossy ganoderma extract and preparation method and use thereof
  • Glossy ganoderma extract and preparation method and use thereof
  • Glossy ganoderma extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of Ganoderma lucidum extract:

[0038] Using Ganoderma lucidum broken spore powder as raw material, first reflux and degrease with petroleum ether (60-90°C) for 2 times, each time for 30 minutes, the degreased spore powder evaporates until there is no ether smell; Extract 3 times, half an hour each time, combine the extracts, recover the ethanol to extract, and obtain the ganoderma lucidum extract.

[0039] Effect test on cell differentiation:

[0040] Nerve growth factor (NGF) is one of the important neurotrophic factors in the body. It can promote the development and differentiation of the central and peripheral nervous systems, maintain the normal function of the nervous system, and accelerate the repair of the nervous system after injury. Current research shows that when central cholinergic neurons and some motor neurons are injured (hypoxia, neurotoxicity, virus infection, mechanical injury), NGF can provide protection, reduce the degree of injury, and...

Embodiment 2

[0057] Preparation of Ganoderma lucidum extract:

[0058] Using Ganoderma lucidum broken spore powder as raw material, first reflux and degrease with petroleum ether (60-90°C) for 2 times, each time for 30 minutes, the degreased spore powder evaporates until there is no ether smell; Extract 3 times, half an hour each time, combine the extracts, recover ethanol until it is in the form of an extract; mix in diatomaceous earth at a ratio of 1:1 between diatomaceous earth and extract, evaporate to dryness under reduced pressure at 60°C until there is no alcohol smell Ultrasonic extraction 3 times with 5 times the amount of chloroform, and recover chloroform; 3 times ultrasonic extraction with 5 times the amount of ethyl acetate, combine the extracts, recover the solvent under reduced pressure until dry, and obtain the powder of Ganoderma lucidum extract.

[0059] The Ganoderma lucidum extract obtained in this example was compared with NGF.

[0060] attached image 3 It is the mo...

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PUM

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Abstract

The invention discloses a glossy ganoderma extract, its preparation method and use, wherein the glossy ganoderma extract is prepared through the following steps, using wall-broken glossy ganoderma spore powder as raw material, degreasing with petroleum ether, volatilizing, extracting the powder by ethanol backflow, concentrating the extract to concrete form, preparing powder form from the obtained concrete substance, chloroform extracting solid body, extracting again with acetic acid ethyl ester, decompressing and drying the extract. The extract can be used for preparing the medicament for treating nerve damage and nerve retrogression pathology.

Description

technical field [0001] The invention relates to a Ganoderma lucidum extract, in particular to a fat-soluble extract of Ganoderma lucidum spore powder, and also relates to a preparation method of the extract and its application in preparing medicines. Background technique [0002] Ganoderma lucidum is a basidiomycete polyporaceae Ganoderma plant, and its growth process includes three stages: fruiting body, mycelium and spore powder. Ganoderma lucidum has been considered as an effective tonic and strong medicine since ancient times, and the most widely used is the fruiting body of Ganoderma lucidum. Studies have shown that the main chemical components of Ganoderma lucidum are polysaccharides, nucleosides, triterpene acids, sterols, biological Alkalis and amino acids, etc., have a wide range of effects in many aspects such as sedation, cardiac strengthening, anti-aging, improving the body's ability to withstand hypoxia, anti-fatigue, and anti-tumor. ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61P25/00A61P25/08A61P25/14A61P25/16
Inventor 秦正红张丽彭少平顾振纶
Owner 苏州中药研究所有限公司
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