8 results about "Glycerophosphates" patented technology

The invention discloses a preparation method of high-purity magnesium glycerophosphate, and belongs to the technical field of organic salt synthesis. According to the method, glycerol and phosphoric acid which are low in cost and easy to obtain are taken as starting raw materials, esterification reaction is firstly carried out under the action of a specific catalyst to generate glycerophosphate, then a magnesium source is added for salt forming reaction, and a high-purity magnesium glycerophosphate product is finally obtained by regulating and controlling the type of the catalyst, the reaction temperature, the pH value and the reaction time and combining a step-by-step purification process. The method has the advantages of easily available raw materials, recyclable catalyst, mild reaction conditions, simple process flow, high product purity, no generation of harmful impurities and the like, solves the problems of high raw material cost, complex process, difficulty in ensuring the product purity and the like in the existing magnesium glycerophosphate synthesis method, and is suitable for industrial large-scale production.

The invention relates to the technical field of microchannels and synthesis, and particularly discloses a method for preparing glycerophosphate by using a microchannel continuous flow method, which comprises the following steps: S1, adding a catalyst into phosphoric acid, and uniformly mixing to obtain a feed liquid A, the catalyst containing phosphate and organic acid; s2, adding water into glycerin and mixing to prepare feed liquid B; and S3, respectively introducing the feed liquid A and the feed liquid B into a microchannel reactor, and carrying out esterification reaction under a heating condition to obtain a glycerophosphate solution. The invention solves the problems of long reaction time and more side reactions of the conventional synthesis method by using a fluid chemical method, and improves the production efficiency.

The invention discloses an SS / CTGF composite biological material based on carboxyl chitosan as well as a preparation method and application of the SS / CTGF composite biological material. A substance containing active sericin (SS) and CTGF at the same time is extracted from genetic engineering silkworm cocoons over-expressing human connective tissue growth factors (CTGF) by utilizing an alkali extraction-acid protection method. Furthermore, the active substance, carboxyl chitosan and beta-glycerophosphate are used as raw materials, and the CH-SS / CTGF composite hydrogel biological material with the core-shell structure is prepared through thermal induction gelation. The material has the characteristics that the water content is adjustable, the mechanical property is controllable, and active protein can be quickly released. Compared with pure sericin, the active SS / CTGF substance and the composite hydrogel thereof can more remarkably promote cell proliferation and migration, and show good biocompatibility. The biological material prepared by the invention has wide application prospects in the fields of wound healing, drug delivery and regenerative medicine.

The invention discloses an anticorrosive coating suitable for ocean engineering and a preparation method thereof.The preparation method comprises the steps that firstly, the surface of titanium dioxide graphene composite fiber is modified with nano silicon dioxide, a fiber material is obtained, then the fiber material is modified through glycerophosphate, and a modified fiber material is obtained; then compounding the porous boron nitride hollow microspheres with hollow nano zinc powder to obtain a powder material, and then carrying out modification treatment on the powder material through polyvinyl alcohol to obtain a modified powder material; then uniformly mixing a dispersing agent, a wetting agent, a defoaming agent, tributyl methyl ammonium tetrafluoroborate, 1-hydroxyethyl-3-methylimidazolium tetrafluoroborate and deionized water, so as to obtain a premix; adding the premix into the water-based acrylic emulsion, uniformly stirring and mixing, continuously adding the thickening agent and the modified powder material, carrying out microwave irradiation treatment, finally adding the modified fiber material, carrying out electron beam irradiation, adding the film-forming agent, and carrying out ultrasonic oscillation treatment under the condition of a pulsed magnetic field, so as to obtain the coating. The anti-corrosion coating can exert good anti-corrosion performance in a complex marine environment, can inhibit adhesion growth of marine microorganisms and the like on the surface of the coating, and guarantees the service life of the anti-corrosion coating.

The invention relates to a method for efficiently synthesizing high-purity ferric glycerophosphate. The method comprises the following steps: dropwise adding a sodium hydroxide aqueous solution into a glycerophosphate aqueous solution at 40-50 DEG C in N2 atmosphere to adjust the pH value to 5-6, dropwise adding a ferrous salt aqueous solution, fully mixing, slowly dropwise adding an alkali aqueous solution to adjust the pH value to 7-8, carrying out a heat preservation reaction for 3 hours, reducing the temperature to room temperature, and continuing the heat preservation reaction; after the reaction is finished, discharging, concentrating to remove water, adding an alcohol solution for recrystallization, and filtering to obtain a ferrous glycerophosphate crude product; adding ethanol into the crude product to prepare turbid liquid, dropwise adding the turbid liquid into an oxidation kettle filled with glycerophosphate, carrying out curing reaction after dropwise adding to obtain an iron glycerophosphate crude product, and filtering, washing and drying the crude product to obtain an iron glycerophosphate pure product.

Lysosomal membrane permeabilization is an evolutionarily conserved hallmark of stress-induced cell death. Here the inventors show that the major stress-inducible heat shock protein 70 (Hsp70) enhances cell survival by stabilizing lysosomes through a pH-dependent high affinity binding to an endo-lysosomal anionic phospholipid bis(monoacylglycero)phosphate (BMP; also referred to as lysobisphosphatidic acid). The positively charged ATPase domain of Hsp70 is responsible for the binding but the substrate-binding domain is also required for effective stabilization of lysosomes. Importantly, the cytoprotective effect can be obtained by endocytic delivery of recombinant Hsp70 and specifically reverted by extra cellular administration of BMP antibodies or Hsp70 inhibitors. Thus, this protein-lipid interaction opens exciting possibilities for the development of cytoprotective and cytotoxic lysosome-specific therapies for the treatment of degenerative diseases and cancer, respectively.

The application relates to the technical field of plant protection, and discloses the use of lipid-related metabolites of banana tissues in resisting banana wilt. The application finds the role of lipid-related metabolites generated in banana corm tissues in resisting Fusarium oxysporum f. sp. Cubense Tropical Race 4 (TR4), and for the first time reports the function of lipid-related metabolites 16-hydroxyhexadecanoic acid, erucic acid, D-sphingosine and glycerophosphates in inhibiting the activity of TR4 in plants in vivo and in vitro. The application shows that the lipid-related metabolites generated by plants have a significant prevention and control effect on TR4, and provides a green method and reference for the prevention and control of TR4.

The invention discloses a preparation method of glycerophosphate, and belongs to the field of pharmaceutical and chemical engineering technologies and food nutrition fortifiers. The preparation method comprises the following steps: (1) adding glycidol and a phosphating agent into a solvent for reaction, and treating after the reaction is finished to obtain a glycerophosphate solution; and (2) adding a metal oxide into the glycerophosphate solution obtained in the step (1), carrying out a stirring reaction, filtering after the reaction is finished, adding ethanol into the obtained filtrate, crystallizing, filtering and washing to obtain calcium glycerophosphate. According to the method, the adopted raw materials are simple and easy to obtain, excessive protection is not needed in the reaction process, the reaction route is short, the reaction is single and environmentally friendly, and the product yield is high.