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Sunscreen and gel composition, preparation method and application thereof

A technology of gel composition and sunscreen agent, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., to achieve the effects of preventing direct contact, avoiding irritation and allergic effects, and improving UV protection ability

Inactive Publication Date: 2011-10-12
SHANGHAI LIGHT IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology provides a preparation method of oily gel, which is suitable for water-in-oil emulsification system, but has certain limitations in application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of the sunscreen gel composition of the present invention is usually first to prepare chitosan / glycerophosphate hydrosol, then add chemical sunscreen agent, after mixing evenly, the resulting hydrosol containing sunscreen agent is converted into a gel by heating , to complete the coating of the sunscreen.

[0025] The preparation of chitosan hydrogel refers to the method published in "Carbohydrate Polymers" 2001 Volume 46 by A. Chenite et al. Dissolve chitosan in 0.1M dilute acid solution, adjust the pH value at about 7.02, slowly add the aqueous solution of glycerol phosphate dropwise, and stir rapidly for 30 minutes to obtain the temperature-sensitive hydrogel of chitosan / glycerophosphate.

[0026] The above-mentioned acids are known in the art to facilitate the dissolution of chitosan in water to form an aqueous solution. The acid includes, for example, acetic acid, hydrochloric acid, oxalic acid, citric acid, lactic acid or mixtures thereof. ...

Embodiment 1

[0043] 0.2 g of chitosan powder was dissolved in 0.9 ml of 0.1 M acetic acid solution to form chitosan acetic acid solution. Stir at room temperature. After the chitosan is completely dissolved, let stand to remove air bubbles. Dissolve 0.4 gram of sodium glycerophosphate powder in 1.0 gram of deionized water, add it dropwise to the chitosan acetic acid solution under stirring, and continue stirring for 30 minutes after adding. Dissolve 0.2 gram of benzophenone-4 in 0.4 gram of deionized water, slowly add it dropwise to the above-mentioned chitosan-sodium glycerophosphate hydrosol, continue stirring for 15 minutes after adding, pour into a stoppered test tube and put Put it into a constant temperature incubator at 37°C, and coagulate into a gel for 25 minutes to obtain a sunscreen system coated with a temperature-sensitive hydrogel of 3.1 grams of chitosan / sodium glycerophosphate. The loading rate of benzophenone-4 reaches 80% by HPLC detection; the absorbance of the obtained...

Embodiment 2

[0045] 0.2 g of chitosan powder was dissolved in 0.9 ml of 0.1 M hydrochloric acid solution to form a chitosan hydrochloric acid solution. Stir at room temperature. After the chitosan is completely dissolved, let stand to remove air bubbles. Dissolve 0.4 gram of sodium glycerophosphate powder in 1.0 gram of deionized water, add dropwise to the chitosan hydrochloric acid solution under stirring, and continue stirring for 30 minutes after adding. Dissolve 0.2 gram of benzophenone-4 in 0.4 gram of deionized water, slowly add it dropwise to the above-mentioned chitosan-sodium glycerophosphate hydrosol, continue stirring for 15 minutes after adding, pour into a stoppered test tube and put Put it into a constant temperature incubator at 37°C, and coagulate into a gel for 25 minutes to obtain a sunscreen system coated with a temperature-sensitive hydrogel of 3.1 grams of chitosan / sodium glycerophosphate. The loading rate of benzophenone-4 was detected by HPLC to reach 81%; the absor...

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Abstract

The invention provides a sunscreen and gel composition, a preparation method and an application in cosmetics thereof. The sunscreen and gel composition comprises the following components in percentage by weight: 2 to 20 percent of chitin, 5 to 25 percent of glycerophosphate, 2 to 20 percent of sunscreen, and 40 to 80 percent of water, on the basis of the total weight of the sunscreen and gel composition. The sunscreen and gel composition can stably cover the sunscreen to prevent the sunscreen from directly contacting with human skins and effectively avoid irritation and allergy of a human body, and can remarkably improve the ultraviolet protection capability of sunscreen products.

Description

technical field [0001] The invention relates to a sunscreen gel composition and its preparation method and application, in particular to a sunscreen gel composition containing chitosan and its preparation method and application. Background technique [0002] The sunscreen agents widely used in the world can be roughly divided into two types according to their different mechanisms, namely physical ultraviolet shielding agents and chemical ultraviolet absorbers. Among them, physical sunscreens are mainly titanium oxide or zinc oxide; chemical sunscreens are mainly substances containing unsaturated or unpaired electron groups, including p-aminobenzoic acid (PABA) and its esters, anthranilate, water, etc. Salylic acid esters, p-methoxycinnamic acid esters, benzophenone and its derivatives, methane derivatives and camphor derivatives, etc. In recent years, the reports of adverse reactions caused by chemical sunscreen ingredients are on the rise. Adverse reactions include allergi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/55A61K8/02A61Q17/04
Inventor 强正
Owner SHANGHAI LIGHT IND RES INST
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