Chitosan low-temperature hydrogel and preparation method thereof
A temperature-sensitive hydrogel and chitosan technology, applied in chitosan low-temperature hydrogel and its preparation method and in the field of medicine and biology, can solve the problems of shrinking the application of biological materials, achieve low gelation temperature, The effect of short gelation time
Active Publication Date: 2015-11-11
GUANGDONG OCEAN UNIVERSITY
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However, hydrogels directly prepared from graphene oxide and chitosan are not thermosensitive, which greatly reduces their application in biomaterials
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[0024] In order to make the purpose, technical solution and advantages of the present invention clearer, the specific implementation manners of the present invention will be described in detail below. Apparently, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.
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The invention provides a simple mixing preparation method with which a gel form of chitosan / graphene oxide / beta-isodium glycerophosphate thermosensitive hydrogel can be formed under a temperature below 37 DEG C. Through rheological tests, the influences of chitosan concentration, beta-isodium glycerophosphate concentration and graphene oxide concentration upon chitosan hydrogel gelling temperature and time are researched. As a result, the chitosan concentration, beta-isodium glycerophosphate concentration and graphene oxide concentration are negatively correlated to chitosan thermosensitive hydrogel gelling temperature and time.
Description
technical field [0001] The invention relates to a chitosan low-temperature hydrogel, a preparation method thereof and an application in medical biology. Background technique [0002] Chitosan is the only alkaline polysaccharide in nature composed of glucosamine and N-acetylglucosamine. It is obtained from chitin, which is very abundant in crustaceans, through alkalization and deacetylation. Linear mucopolysaccharide, which is insoluble in water, can dissolve in water under acidic conditions due to the protonation of the amino group on its structure and make it positively charged, so it has gelation and film-forming properties. Chitosan with good biocompatibility, special biological activity (antibacterial, hemostasis, promotion of wound healing, prevention of tissue adhesion, anti-tumor, etc.) and wide range of sources has been widely used in the fields of clinical medicine, regenerative medicine and drug carrier [2] . The outstanding biocompatibility of chitosan makes chi...
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IPC IPC(8): C08L5/08C08K3/04C08K5/521
Inventor 李承勇卢琼方吉宏武刘书成何蕾高静邵海艳
Owner GUANGDONG OCEAN UNIVERSITY