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Method for synthesizing calcium glycerinophosphate

A technique for calcium glycerophosphate and its synthesis method, which is applied in the field of synthesis of calcium glycerophosphate, can solve problems such as obsolete production methods, expensive prices, and complex production processes, and achieve the effects of stable quality, low cost, and simple processes

Active Publication Date: 2008-07-16
RES INST OF PHYSICAL & CHEM ENG OF NUCLEAR IND
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Although there is production in China, the production scale is relatively small, the production method is outdated, and most of its products are used in food and medicine
Calcium glycerophosphate produced abroad has been widely used in toothpaste as an additive, but there are many raw materials added in the production, the production process is complicated, and the price is expensive

Method used

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  • Method for synthesizing calcium glycerinophosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Pharmaceutical grade glycerin 1000ml Food grade phosphoric acid 1060ml

[0016] The temperature is 120℃ and the vacuum is 0.05MPa

[0017] Esterification reaction time 7 hours

Embodiment 2

[0019] Pharmaceutical grade glycerin 2500ml Food grade phosphoric acid 2500ml

[0020] The temperature is 150℃ and the vacuum is 0.1MPa

[0021] Esterification reaction time 14 hours

[0022] When the temperature drops to about 110° C., 2000 ml of deionized water is taken to dilute the product obtained from the chemical reaction of the above-mentioned examples 1 and 2, and 0.3% activated carbon of the mass of the reaction system is added for decolorization. Pour the decolorized reaction product into an ultrasonic stirrer, and add 60 g of food-grade calcium hydroxide with a mass concentration of 6%. The reaction was stirred for 3-5 hours and filtered. Bubble CO into the filtrate 2 , so that the pH of the filtrate is 8-10, stop feeding carbon dioxide and filter. 45% (volume) food-grade ethanol of the filtrate was added to the filtrate for precipitation. Then, it is dried by a spray dryer, wherein the inlet air temperature is 110° C., and the air frequency is 60 Hz to obtain...

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Abstract

The invention discloses a synthesis method of calcium glycerophosphate. The method includes the following procedures: esterification is performed in a reactor with pharmaceutical-grade glycerine and food-grade phosphonic acid as the raw materials; cooling the reaction solution after completion of the reaction and adding deionized water for dilution; adding active carbon into the solution for decolorization; then adding a certain amount of calcium hydroxide and filtering the reactants to get a clear filtrate after reaction under ultrasonic wave agitation; pumping CO2 into the filtrate to keep PH of the filtrate ranging from 8 to 10 and then filtering again; then adding alcohol into the filtrate and performing spray drying after agitation. The white powder obtained is the product. The invention has the advantages of simple process and low cost. The synthesized calcium glycerophosphate has stable quality and meets the standard of European Pharmacopoeia (63 Edition).

Description

technical field [0001] The invention belongs to a production method of a toothpaste additive, in particular to a synthesis method of calcium glycerophosphate. Background technique: [0002] Calcium glycerophosphate is widely used in food, medicine, and toothpaste. When used in toothpaste, it can reduce tooth enamel demineralization or enhance its remineralization, and can reduce tooth cavity. Although there is production in China, the production scale is relatively small, the production method is outdated, and its products are mostly used in food and medicine. Calcium glycerophosphate produced abroad has been widely used in toothpaste as an additive, but there are many raw materials added in the production, the production process is complicated, and the price is expensive. Invention content: [0003] The present invention proposes in order to overcome the shortcoming that exists in the prior art, and its purpose is to provide a kind of production technology simple, with l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10
Inventor 李强王红朱昱郝连发于景阳周红艳
Owner RES INST OF PHYSICAL & CHEM ENG OF NUCLEAR IND
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