6 results about "Post stroke" patented technology

The present invention relates to a biomarker composition for diagnosing stroke or post-stroke neurological damage, for diagnosing the severity of stroke or post-stroke neurological damage, and for predicting stroke prognosis, and the like. Using an ischemic stroke mouse disease model, a tissue damage analysis and a behavioral analysis were performed, and the mRNA level expression was confirmed, and as a result, Prox1 or Dcx could be selected as a biomarker. In addition, it was confirmed that the expression of Prox1 or Dcx increased as the severity of stroke or post-stroke neurological damage was higher, and thus the present invention is expected to be useful for diagnosing stroke or post-stroke neurological damage, for diagnosing the severity of stroke or post-stroke neurological damage, and for predicting stroke prognosis.

The application discloses a tail suspension test device and method for evaluating the behavioral despair of mice after stroke, wherein a slope plate is arranged below the hanging piece for hanging the mice in the hanging chamber, so as to prevent the mice from struggling due to movement coordination disorders, to help the suspended mice keep balance, and to prevent the mice from shaking even if the movement ability of the mice is impaired, and the application is particularly suitable for evaluating the despair of the mice with impaired movement coordination after stroke. The application supports part of the body weight of the mice through the slope plate, the pain caused during the test is slight, and the application can also be used for rats once the size of the device is adapted to the rats. The application is a modified detection method (mTST for short) of TST, and is used for evaluating the behavioral despair of the mice after stroke. The application can be applied to the evaluation of the curative effect of antidepressant drugs on the model mice of chronic mild stress (CMS) and post-stroke depression (PSD), and is favorable to the basic research of diseases such as PSD and the clinical transformation of drugs.

The invention relates to a traditional Chinese medicine composition for preventing constipation after stroke, an application and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 to 15 parts of fructus aurantii, 9 to 12 parts of radix aucklandiae, 10 to 15 parts of fructus akebiae, 6 to 8 parts of cassia twig, 10 to 12 parts of vinegar rhizoma cyperi, 6 to 8 parts of rhizoma zingiberis, 10 to 15 parts of poria cocos and 3 to 5 parts of rhizoma cimicifugae. The traditional Chinese medicine composition disclosed by the invention is reasonable in compatibility, has the effects of relaxing bowel, warming yang, relaxing bowels, invigorating spleen, replenishing qi, ascending lucidity, descending turbid and the like, promotes the recovery of normal conduction functions of intestinal tracts, and effectively prevents the occurrence of early constipation of apoplexy patients.

Astrocytes are known to regulate the body responses to diseases and injuries in central nervous system (CNS). Embodiments of the instant disclosure relate to biomaterial for delivering extracellular vesicles derived from reactive cell populations for improving brain healing after injury. Also provided are methods of improving angiogenesis, axonogenesis, or inducing tissue repair using the disclosed biomaterials. Also provided are methods of making the biomaterials.

Disclosed herein are methods of reducing or preventing cerebral edema in a subject after a stroke by administering systemically a therapeutically effective amount of a PD-1 agonist to the subject. Also disclosed herein are methods of treating neuroinflammation, improving gait, improving sensorimotor deficits, reducing the number of PD-1 positive monocytes in the brain, decreasing intracranial pressure, shifting the phenotype of monocytes in the brain from a classical inflammatory subtype to a non-classical subtype, and limiting or reducing secondary inflammatory injury, reducing a risk of a second or more stroke events in a subject after a stroke.

A method of predicting an effect of ischemic stroke on an individual's cognitive status comprises (1) acquiring at least one medical brain image of an individual's brain after the ischemic stroke of the individual; (2) processing the medical brain image to obtain at least one feature of the image; (3) generating a gray matter brain age (GMBA) value of the individual based on the at least one feature of the image; and (4) predicting an effect of the ischemic stroke on the individual's post-stroke cognitive status (PSCI) using the GMBA value.