103results about How to "Improve damage" patented technology

A tissue culture model of oxygen / glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the incubation medium a model is established that shows conspicuous similarities with the temporal and special development of cell death in vivo: selective and delayed CA1 damage, a damage mitigated by blockade of the NMDA and AMPA receptors, and a striking augmentation of damage by high levels of glucose.

The invention discloses a coal mine gob-side entry retaining side supporting method. The coal mine gob-side entry retaining side supporting method comprises the following steps of supporting the coal mine gob-side entry retaining side through intensive individual hydraulic supporting columns; constructing anchor cable supports for the gob-side entry retaining top plates based on the original rocker bolt supports, enabling the gob-side entry retaining to adopt double-line rocker bolt supports, enabling the distance between the rocker bolts to be 2 m and the row distance to be 2.2 m and enabling the anchor bolts which are close to one side of the coal wall to be installed along a certain inclination angle and the anchor bolts which are close to one side of a gob to be installed perpendicular to the top plates; constructing a row of single hydraulic supporting columns on the inner side of the intensive single hydraulic supporting columns after the designed pretress of the anchor bolts is achieved and enabling the column distance to be 1.2 to 1.5 m; enabling the insensitive single hydraulic supporting columns to be out successively from back to front and enabling supplement single hydraulic supporting columns and the installed anchor bolts to be formed into a gob-side entry retaining side auxiliary supporting system. The coal mine gob-side entry retaining side supporting method solves the problem that the gob-side entry retaining side supporting is difficult.

The invention discloses a heat-reflecting thermal insulation coating which is characterized by comprising the following ingredients by weight: 15 to 30 parts of epoxy resin, 10 to 40 parts of a filler, 0.1 to 7 parts of an additive and 1 to 15 parts of a curing agent. The heat-reflecting thermal insulation coating is a novel material changing the conventional thermal insulation manner, not only is anti-corrosion, but also can effectively insulate an object from sunlight infrared radiation heat under the condition that the coating is only 1 mm thick, and has the advantages that the temperature difference between the wall of a tank and a liquid in the tank can be 7 to 12 DEG C, and the temperature of the storage tank can be further lowered by 3 to 8 degrees compared with the condition that the storage tank is treated according to the conventional water spraying method.

Embodiments of the invention relate generally to the use of formulations comprising DMSO and MSM to treat arthritis (such as osteoarthritis), pain, inflammation, and / or degeneration. DMSO and MSM formulations are administered orally and / or topically in several embodiments and provide effective treatment of both chronic and acute symptoms of arthritis (e.g., osteoarthritis), pain, inflammation, and / or degeneration. Solid forms of DMSO are provided in several embodiments.

A hydraulic control device for a lockup clutch prevents stagnation and accumulation of air bubbles in a torque converter when a vehicle is at a stop at low oil temperature, preventing impairment of vehicle drive performance caused by insufficient transmission torque at the time of start of the vehicle. It occurs sometimes that air-mixed hydraulic oil is supplied into a torque converter (32) from a second oil path (132) when a vehicle is at a stop, with a transmission set to a drive range such as a D range, at a low oil temperature in a time, for example, immediately after an engine (30) is started. In such a case, when a lockup clutch is disengaged, in which a second line hydraulic pressure (PL2) is supplied from the second oil path (132) to the lockup clutch (28), a third oil path (134) is interrupted (closed) to prohibit discharge of the hydraulic oil. As a result, despite large pipe path resistance due to high viscosity, the hydraulic oil in the torque converter (32) is reliably discharged from a first oil path (130) to an oil cooler (142) via a cooler oil path (140). Thus, air bubbles in the torque converter (32) are reduced with the discharge of the hydraulic oil.

The invention provides a heat dissipation structure of a module spot lamp. The heat dissipation structure includes lamp modules, shell assemblies and a pressing cover, the shell assemblies are a plurality of detachable shells, the shell assemblies are arranged as the multiple detachable shells, meanwhile, the lamp modules are detachably mounted in the shell assemblies, the pressing cover is used for packaging, thus the module spot lamp can be conveniently disassembled and maintained, meanwhile, the purpose of good heat dissipation can further be achieved, the shell assemblies are all set as copper materials, and heat energy generated by the lamp modules is further improved; and the lamp modules and the shell assemblies are separately produced and manufactured, the maintenance cost is greatly saved, quick maintenance after the fault of the lamp modules is convenient, and meanwhile, the purpose of no needing to replace the entire lamp is achieved. The shell assemblies are arranged as themultiple detachable shells, the maintenance efficiency of the shell assemblies is greatly improved, and better heat dissipation is further realized.

The invention provides automatic labelling method and device. The device comprises a label sucking module unit and a control unit, wherein the label absorbing module unit comprises one or more label sucking components; each label sucking component comprises a labelling head and a pressure detection sensor; the control unit is set to be used for receiving a labelling pressure real-time value sent by the pressure sensor; according to the received labelling pressure real-time value, a motion execution unit drives the label sucking module unit so as to enable the label sucking components in the label sucking module unit to move to the preset position; and the label sucking components are used for executing the corresponding labeling operation corresponding to the preset position after moving to the preset positions. Through detecting the pressure, the pressure of the labelling head acted on a labelling object product is always accurately controlled within a pressure value range allowable by the labelling object product, so that the occurrence of the phenomenon that the product is damaged due to over pressure is avoided.

The invention discloses a deep thick and hard rock stratum roof directional long drill hole staged fracturing weakening method and system, and relates to the technical field of coal mining. The method comprises the following steps: determining a fracturing target horizon according to mining area geological data and to-be-treated working face monitoring data; a drill site construction position is determined, and drilling track parameters are determined in the fracturing target horizon; a fracturing assembly is installed, fracturing construction parameters are determined, and the operation sequence of drilling construction and fracturing construction is determined; and drilling construction is conducted according to the operation sequence, fracturing construction is conducted through the fracturing assembly, and the stability condition of the roadway is monitored in the whole process and before and after. The technical scheme aims at weakening far-field strong stress of a top plate of a thick and hard coal rock stratum overlying a deep coal mine underground roadway, and is particularly suitable for design of a directional long drilling hole fracturing weakening scheme in the field of deep thick and hard rock stratum top plate pressure relief and roadway protection engineering. And the roadway deformation condition under the disturbance influence of advanced high supporting stress and mining strong stress of the working face is improved.

The invention discloses a rectifier for use at a high temperature. The rectifier comprises a conductive type semiconductor substrate, a conductive type epitaxial layer, a plurality of conductive type doped regions, an edge conductive type doped region which surrounds the plurality of conductive type doped regions, at least one outer conductive type doped region which surrounds the edge conductive type doped region, a first metal layer which covers the plurality of conductive type doped regions entirely and at least contacts a part of the edge conductive type doped region, and a second metal layer which is an outer conductive type doped region of the edge conductive type doped region and is formed at the back of the conductive type semiconductor substrate. The rectifier has the characteristics of a low forward voltage and a low reverse leakage current, so that the rectifier is suitable to be used in an operating environment at the high temperature; and in addition, in order to improve the impact resistance property of an element, a structure which can reduce electric field accumulation is arranged on the periphery of the rectifier, so that the damage situation of the element is greatly improved.

The invention discloses an application of eupatorin in preparation of a medicine for preventing or treating alcoholic liver diseases, and belongs to the technical field of medicines. According to theinvention, an alcoholic liver disease animal model and a cell model are established through alcohol stimulation, the influence of eupatilin on alcohol-induced hepatocyte damage, oxidative stress and alcohol metabolic enzyme activity is observed, and research finds that eupatilin can significantly reduce alcohol-induced hepatocyte damage in both in-vivo and in-vitro experiments; oxidative stress isrelieved, the activity of alcohol metabolic enzymes is enhanced, and a new thought is provided for preventing and treating alcoholic liver diseases.

The invention discloses a probe sleeve with shock-proof and anti-collision performance, which mainly comprises a probe sleeve main body and is characterized in that the probe sleeve main body is provided with a probe measurement main body sleeve 23 and a shock-proof and anti-collision body, wherein a scintillator chamber 4 and a photomultiplier chamber 8 are arranged in the probe measurement mainbody sleeve 23, and a glass window 6 is arranged between the scintillator chamber 4 and the photomultiplier chamber 8; and the shock-proof and anti-collision body 24 of the probe sleeve main body is arranged at the lower end of a photomultiplier seat 21, and one to more groups of pressing rings 9, 15 and 18 and one to more groups of springs 12, 14 and 16 are arranged in the shock-proof and anti-collision body 24 to buffer shock and collision. The probe sleeve has the advantage of greatly reducing the damage rate of a scintillation gamma probe to below 10 percent from 20 percent.

The invention belongs to the field of pharmacy, relates to application of leonurine to preparation of a medicine for treating dementia and in particular relates to application of the leonurine to preparation of a medicine for treating vascular dementia. A rat VD model is successfully copied and an experiment result shows that the leonurine can remarkably improve cognitive impairment caused by the VD and alleviate impairment of long-term postsynaptic inhibition; the content of hydrogen peroxide (H2O2) and glutamate is reduced, the specific value of NR2A / 2B is improved and the expression of LC3II / LC3I and Beclin-1 is regulated down, so that autophagic flux is inhibited. The leonurine can be used as a treatment medicine for treating the dementia, especially brain injury diseases caused by the VD.

The invention relates to the field of high power laser and particularly relates to a longitudinal local beam-expanding triple frequency laser terminal optical system. The system comprises a double frequency crystal, a first cylindrical focusing lens, a triple frequency crystal and a second cylindrical focusing lens which are sequentially arranged in the transmission direction of an incident laser beam, wherein the triple frequency crystal and the second cylindrical focusing lens are obliquely arranged, the triple frequency crystal inclines along a vertical rotary shaft of the triple frequency crystal, the second cylindrical focusing lens inclines along a horizontal rotary shaft of the second cylindrical focusing lens, and the vertical rotary shaft of the triple frequency crystal and the horizontal rotary shaft of the second cylindrical focusing lens are mutually orthogonal. According to the longitudinal local beam-expanding triple frequency laser terminal optical system, local beam expanding can be realized to reduce the mean flux of the triple frequency laser, the severe ultraviolet damage problem is alleviate, and meanwhile, the implementation cost and the system complexity are reduced.

The invention relates to a front spiral guiding device for horizontal spiral centrifuge cavitation resisting. The front spiral guiding device is arranged in a material distribution chamber, the guiding device comprises a front spiral shaft, the right end of the front spiral shaft is fixed to the left end of a spiral conveyor shaft in a coaxial mode, and the left end of the front spiral shaft is located in the material distribution chamber and faces the outlet end of a feeding pipe; a gap between the front spiral guiding device and the inner wall of the material distribution chamber forms a flow channel, and the flow channel communicates an inner cavity of a rotating drum through a discharging outlet; and a first front spiral blade and a second front spiral blade are spirally arranged on the periphery of the front spiral shaft in the direction of a central axis of the front spiral shaft in an overlapping mode, the spiral direction of the first front spiral blade and the second front spiral blade is opposite to the spiral direction of blades of a spiral conveyor.

The invention provides an extraction method and application of mulberry leaf alkaloids, and belongs to the technical field of application of mulberry leaf alkaloids. The extraction method of the mulberry leaf alkaloids comprises the following steps: 1) mixing mulberry leaves with water, carrying out ultrasonic extraction for 1-3 times so as to obtain extracts, and combining the extracts so as to obtain a crude mulberry leaf alkaloid extract; and 2) sequentially performing decompressed concentration, D101 macroporous resin adsorption, cationic resin adsorption and AB-8 macroporous resin adsorption on the crude mulberry leaf alkaloid extract so as to obtain the mulberry leaf alkaloids. In the step 1), the power of the ultrasonic extraction is 500-700W; the temperature of the ultrasonic extraction is 55-65 DEG C; and the time of each ultrasonic extraction is 50-70min. The mulberry leaf alkaloids extracted by the extraction method are high in total alkaloid content, so that, the mulberry leaf alkaloids are capable of significantly reducing levels of markers of liver fibrosis; and the mulberry leaf alkaloids has improvement effects on hepatic fibrosis in mice.

The invention discloses an amorphous alloy composite shell which comprises an amorphous alloy prefabricated assembly and a plastic cement combination assembly. The amorphous alloy prefabricated assembly comprises one or more amorphous alloy prefabricated parts, the plastic cement combination assembly comprises multiple plastic cement combination parts, and the thickness of the amorphous alloy prefabricated parts is 0.05-0.5mm. The amorphous alloy prefabricated assembly and the plastic cement combination assembly are mutually cooperated for use to jointly form the needed composite shell. Preferentially, the thickness of the amorphous alloy prefabricated parts is 0.05-0.5mm and can meet the requirement for specific strength, the thickness is reduced by 50% or more compared with the thicknessof a common metal shell, and meanwhile the electromagnetic shield problem can be effectively solved by using the plastic cement combination assembly.

The invention relates to a swimming exercise and low-fat diet coordinated intervention method for a hypertensive rat in the development stage. By means of the method, the defects are overcome that thecontent of the fat in an existing low-fat diet is uncertain, and the low-fat diet has negative effects on the neural development learning and memorizing functions of the hypertensive rat in the development stage. In the method, the swimming exercise (60 minutes a day and six days a week) and low-fat diet (the energy supply of the fat is 10.7%) coordinated intervention is provided, the neural development of the hypertensive rat in the development stage is ensured, and meanwhile, the blood pressure decreasing effect is achieved. The blood pressure decreasing effect of the coordinated intervention method on the hypertensive rat in the development stage is better than that of a separate swimming exercise or low-fat diet method on the hypertensive rat in the development stage, meanwhile, the damage of the low-fat diet to the spatial learning and memorizing ability and the hippocampal neural synapse plasticity of the rat is reduced, and the neural development learning and memorizing functions of the hypertensive rat in the development stage are promoted.

The patent discloses application of a tanshinone IIA nano preparation, shown as in .1 and using O-hydroxyethyl chitosan derivative as an entrapping agent, in drugs to prevent or treat cerebral ischemia, particularly nerve injury due to local cerebral ischemia, and belongs to the technical field of nerve protection drugs. The tanshinone IIA entrapped by a nano carrier can quickly pass through the blood brain barrier. Compared with tanshinone IIA, the tanshinone IIA nano preparation has better blocking action upon nerve injury in acute stage of ischemic brain injury; threshold concentration is far lower than the concentration of tanshinone IIA. In addition, it is discovered that tanshinone IIA can promote healing of post-stroke injury and can play well by stimulating regeneration of post-ischemia endogenous nerves; tanshinone IIA entrapped by the nano carrier is more active than tanshinone IIA with the same dosage. The nano preparation herein can treat stroke-caused injury.

The invention relates to a display device and a preparation method thereof, and a display device. The display device comprises a substrate, a pixel definition layer, a light emitting unit and a thin film packaging structure, wherein the pixel defining layer is located on the substrate and defines a pixel area and a non-pixel area, and the light emitting unit is arranged in the pixel area; the thinfilm packaging structure is located on the substrate and covers the pixel definition layer and the light emitting unit; the thin film packaging structure comprises a plurality of inorganic packaginglayers arranged in a stacked mode and organic packaging layers arranged between every two adjacent inorganic packaging layers, a protruding structure is arranged on the surface, away from the pixel definition layer, of at least one organic packaging layer, and the protruding structure on the organic packaging layers is arranged in the non-pixel area. The display device has high bending performance.

The invention discloses a semiconductor structure and a preparation method thereof. The semiconductor structure comprises a substrate; a conducting wire layer positioned on the substrate; a dielectriclayer located on the conducting wire layer; a groove located in the dielectric layer, wherein the bottom end of the groove is connected with the conducting wire layer, and the side wall of the groovehas an inclination angle; a barrier layer located on the dielectric layer and the conducting wire layer at the bottom end of the groove; a metal layer positioned in the groove and on the barrier layer; a plurality of protective layers on the metal layer; and through holes positioned in the plurality of protective layers. According to the invention, the condition that impurities remain on the sidewall of the through hole can be effectively improved, so that the damage to the probe can be effectively reduced during the wafer electrical property test.

The invention relates to the technical field of related tunnel construction, in particular to an upper step base plate minimally invasive blasting structure. A base plate hole is formed in a base plate area of an upper step; the base plate hole comprises bottom angle holes positioned at two horizontal ends, and a middle hole set positioned between the two bottom angle holes; the bottom angle holesadopt detonating cord explosive string structures; a horizontal adjacent hole adopts an air interval explosive loading structure; a vertical adjacent hole is designed according to a conventional light blasting hole; the middle holes beyond the horizontal adjacent hole adopt continuous explosive loading structures; the base plate hole blasting sequence is from middle in sequence; one section of afirst blasthole on an adjacent upper row is behind; through design of hole net parameters of the base plate hole, the explosive unit consumption, the explosive loading structures and the blasting network, the lower step free surface damage degree of the base plate hole is improved; and the rock looseness is better after blasting of the base plate hole, so that the base plate blasting minimally invasive molding in a micro step method is realized.

The invention belongs to the technical field of single-axis robots, and particularly relates to a coordinate type single-axis robot which comprises a shaft body and a mechanical arm and further comprises a sliding block installed on the shaft body in a sliding mode, and the sliding block is provided with a groove; the connecting assembly is installed on the shaft body in a sliding mode, the mechanical arm is installed below the connecting assembly, the connecting assembly comprises an inserting rod, and the connecting assembly is connected with the sliding block by inserting the inserting rod into the groove; after the mechanical arm breaks down, the inserting rod is controlled to be taken out of the groove, namely, the connecting assembly and the sliding block are separated, the sliding block can continue to move at the moment, the connecting assembly and the mechanical arm are kept still, and therefore the mechanical arm and the connecting assembly can be directly taken down from the shaft body, the mechanical arm with the fault is maintained, and the mechanical arm on the whole shaft body does not need to be controlled to stop working. The use is convenient.

The invention belongs to the technical field of medicines, discloses application of Ferrostatin-1 in preparation of medicines for relieving inflammatory bowel diseases, and particularly discloses application of Ferrostatin-1 in preparation of medicines for treating inflammatory bowel diseases. According to the application disclosed by the invention, the effect of the Ferrostatin-1 in a mouse acute experimental colitis model is discussed by establishing the acute experimental colitis model, and a result shows that the Ferrostatin-1 can be used for improving the colitis induced by DSS and has a certain protection effect on colon tissues.

The invention discloses a reinforced concrete column with non-adhesive ends and a preparation method thereof. All longitudinal reinforcing bars in plastic hinge regions at both ends of the column are respectively sheathed by a steel strip corrugated pipe of which the length is twice of the height of the column section, and a 914 adhesive is utilized to attach foam gaskets to the two ends of the corrugated pipe, so that the foam gaskets and the bars in the region form a closed integral body; and thus, a non-adhesive section with a certain length is formed between the longitudinal bar at partial ends and the concrete. The bar strain distribution at the non-adhesive section of the column ends can be uniform, and a yield section with synchronous and slow stress increase is formed, thereby postponing and even preventing the buckling fracture and resilience degeneration, effectively enhancing the ductility and energy consumption capacity of the column end plastic hinge regions, and obviously improving the damage of the concrete in the region due to binding force. The whole system has the advantages of simple structure and favorable economical efficiency, and is convenient for construction.

The invention relates to an inner case separately opened safe case. The inner case separately opened safe case comprises a housing and a support arranged inside the housing, wherein the housing is anairtight cavity with an opening in one side, the inside of the support is provided with a core unit which is equally divided into four square storage cavities, the rear end of every storage cavity isprovided with a hydraulic rod which is controlled by a switch plate above the support, and one side of the support is movably connected with two doors which can close the opening of the housing; the top of the support is slidingly connected with a motor which drives a motor shaft to rotate, the motor shaft is provided in a sleeve mode with a first worm and a second worm, in which pawls are hinged,the motor shaft is also fixedly provided with a ratchet wheel matched with the pawls, and by means of the ratchet wheel, the first worm and the second worm rotate in opposite directions; the first worm is driven by a rotating module to drive a laser source to move, the laser source controls the switch plate, and the second worm drives the doors to open and close through an opening and closing module. The inner case separately opened safe case is small in space occupation and high in safety coefficient, and with multiple storage spaces in one safe case, enables multiple users to separately usedifferent storage cavities.

A sealing device used for a brake piston of a quick press machine comprises a piston top and a brake cylinder rear end cover matched with the piston top, and is characterized in that the piston top isa circular truncated cone type brake piston top; the brake cylinder rear end cover is a circular truncated cone groove type brake cylinder rear cover; the brake piston top and a brake piston body areconnected through a bolt via a reserved bolt hole; the piston top is wrapped with a sealing rubber sleeve matched with the piston top in size; and a hole is reserved in the position, at the bolt holeof the circular truncated cone top, of the sealing rubber sleeve, bolt connection is facilitated, an opening is formed in the bottom of the circular truncated cone, and mounting of the sealing sleeveis facilitated.

The invention discloses application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation. According to the invention, EGCG in greentea is firstly found to be capable of relieving endothelial cell damage in the environment of glucose fluctuation. The invention provides a brand-new selection and thought for treatment of endothelial cell damage caused by glucose fluctuation at present, widens the field of selection of drugs for relieving endothelial cell damage caused by glucose fluctuation and makes a contribution to the development of the technical field.

The invention relates to a silicosis treatment target and application thereof. The treatment target is glycolysis. By regulating and controlling abnormal glycolysis, inhibiting ferroptosis and EMT of epithelial cells and relieving occurrence and development of silicosis, a new direction is provided for medicine development and treatment means related to the silicosis, it is found that abnormal glycolysis occurs in the occurrence and development process of the silicosis, and a theoretical basis is also provided for a clinical auxiliary diagnosis technology of the silicosis.

This application provides a composition comprising hydrogen gas or dissolved hydrogen as an active ingredient for suppressing or preventing abnormality in the intestinal environment of a subject, wherein the abnormality is selected from the group consisting of bacterial translocation and bacterial species composition abnormality of intestinal flora.