Application of O-hydroxyethyl chitosan/tanshinone IIA nano preparation in treatment of ischemic cerebrovascular diseases

A technology of hydroxyethyl chitosan and nano-medicine, which can be used in cardiovascular system diseases, organic active ingredients, nervous system diseases, etc., and can solve unrelated problems
CN109078191AInactive Publication Date: 2018-12-25CAPITAL UNIVERSITY OF MEDICAL SCIENCES +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Publication Date
2018-12-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The patent discloses application of a tanshinone IIA nano preparation, shown as in .1 and using O-hydroxyethyl chitosan derivative as an entrapping agent, in drugs to prevent or treat cerebral ischemia, particularly nerve injury due to local cerebral ischemia, and belongs to the technical field of nerve protection drugs. The tanshinone IIA entrapped by a nano carrier can quickly pass through the blood brain barrier. Compared with tanshinone IIA, the tanshinone IIA nano preparation has better blocking action upon nerve injury in acute stage of ischemic brain injury; threshold concentration is far lower than the concentration of tanshinone IIA. In addition, it is discovered that tanshinone IIA can promote healing of post-stroke injury and can play well by stimulating regeneration of post-ischemia endogenous nerves; tanshinone IIA entrapped by the nano carrier is more active than tanshinone IIA with the same dosage. The nano preparation herein can treat stroke-caused injury.
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Description

technical field

[0001] The invention belongs to the field of neuroprotective drugs, in particular to a novel neuroprotective agent against ischemic stroke damage. Background technique

[0002] Stroke, coronary heart disease, and cancer are listed as three high-risk diseases that threaten human health and life. Stroke not only has the characteristics of high morbidity, high mortality, high disability rate, high recurrence rate and many complications, but also brings a heavy social burden due to poor prognosis during the treatment process. For the treatment of acute ischemic stroke, there are few effective drugs at home and abroad, and there are even rarer drugs for repairing damage after stroke. Therefore, the research and development of stroke drugs not only has high economic value, but also reflects great social value. However, a large amount of clinical experience in traditional Chinese medicine and the results of modern biomedical research suggest that Chinese medicinal...

Claims

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