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Application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation

A technology for endothelial cells and blood sugar fluctuations, which is applied in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., to achieve the effect of simple method, improvement of vascular complications, and improvement of damage

Inactive Publication Date: 2019-03-08
THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether EGCG can improve the damage of endothelial cells in the environment of blood sugar fluctuations has not been reported yet.

Method used

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  • Application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation
  • Application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation
  • Application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation

Examples

Experimental program
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Embodiment

[0023] The invention provides an application of EGCG in the preparation of a medicine for improving endothelial cell damage caused by blood sugar fluctuations, wherein the EGCG is derived from green tea.

[0024] It should be noted that the medicine can be prepared into a pharmaceutically acceptable dosage form, and the dosage form is a solid preparation or a liquid preparation.

[0025] It should be noted that the EGCG can be directly applied with green tea. The specific method is to weigh 2 g of green tea, add 200 ml of boiling water to brew, and drink 10 cups a day.

[0026] HUVEC was used to establish a blood glucose fluctuation model, to investigate the changes of TLR4 signaling pathway and inflammatory factors in the environment of fluctuating hyperglycemia before and after EGCG intervention, and to evaluate the effect of EGCG in improving skin cell damage caused by blood glucose fluctuation.

[0027] 1 Main reagents and instruments

[0028] 1.1 Main reagents

[0029] ...

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Abstract

The invention discloses application of EGCG (epigallocatechin gallate) in preparing drugs for relieving endothelial cell damage caused by glucose fluctuation. According to the invention, EGCG in greentea is firstly found to be capable of relieving endothelial cell damage in the environment of glucose fluctuation. The invention provides a brand-new selection and thought for treatment of endothelial cell damage caused by glucose fluctuation at present, widens the field of selection of drugs for relieving endothelial cell damage caused by glucose fluctuation and makes a contribution to the development of the technical field.

Description

technical field [0001] The invention relates to a new application of EGCG, specifically disclosing the application of EGCG in the preparation of drugs for improving endothelial cell damage caused by blood sugar fluctuations. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in insulin secretion or insulin action. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. Vascular disease is the main chronic complication of diabetic patients, including macrovascular disease and microvascular disease. [0003] A large number of studies have proved that diabetes complications are not only related to the overall control level of blood sugar, but also closely related to blood sugar fluctuations. Blood glucose fluctuation is an independent risk factor for macro...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P3/10A61P9/14
CPCA61K31/353A61P3/10A61P9/14
Inventor 曹艳丽曹田田侯慧敏
Owner THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV
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