32results about How to "Widen the field of choice" patented technology

The invention discloses an asarum total lignan extract and a preparation method and application thereof, belonging to the technical field of medicines. The preparation method comprises the following steps: extracting the root and / or tuber of asarum with a polar solvent and then carrying out concentration and drying so as to obtain an asarum total extract; and dissolving the asarum total extract with water, injecting the dissolved asarum total extract into a macroporous adsorption resin, carrying out gradient elution by using an aqueous ethanol solution, collecting eluate, recovering the solvent and carrying out drying so as to obtain the asarum total lignan extract with a content of 60 to 80 wt%, wherein yield of the asarum total lignan extract is 8.4 wt%. Through a great number of pharmacodynamic tests, it is proved for the first time that the asarum total lignan extract has substantial cough-inhibiting and cough reflex sensitivity-lowering effects which are close to the effects of codeine, and it is found out that the asarum total lignan extract has effects on inhibiting airway inflammations, reducing coughing frequencies and prolonging the incubation period of cough, exerts good prevention and treatment effects on a variety of coughs and can be used for preparation of drugs used for treating diseases related to cough. The asarum total lignan extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention relates to the field of biological medical care, in particular to an application of polypeptide (urotensin II) to preparation of medicines for treating and / or preventing metabolic syndromes / type II diabetes / obesity / diabetes complications. The polypeptide disclosed by the invention has significant effects of reducing the proportion and the weight of tissue fat, improving and alleviating insulin resistance and reducing blood sugar. The polypeptide is novel in effects, easy to synthesize and low in dosage, and has good application and development prospects.

The invention discloses an application of BAIBA (beta-aminoisobutyric acid) in preparation of anti-DM (diabetes mellitus) drugs. A novel treatment means is provided for preparation of the anti-DM drugs, BAIBA is applied to development of DM related drugs, and accordingly, the better DM treatment drugs are prepared. After BAIBA is delivered to a mouse with STZ / HFD (streptozocin / high fat diet) induced DM, the fasting blood-glucose level is remarkably reduced, insulin sensitivity is remarkably improved, and further, with the adoption of BAIBA, gluconeogenesis is reduced and an insulin molecular signal pathway is improved. Therefore, BAIBA can remarkably improve insulin resistance and glycometabolic disorder caused by DM, is an effective target site for DM treatment and can be taken as the novel anti-DM drug for development, and one novel pathway and means is provided for DM detection and treatment.

The invention discloses a total volatile oil extractive of asarum, an extraction method of the total volatile oil extractive and an application of the total volatile oil extractive in preparation of drugs for treating chronic coughs, belongs to the field of natural drugs and discloses a total volatile oil extractive of asarum as well as an extraction method and application of the total volatile oil extractive. The method comprises the steps of placing coarse asarum powder into an extraction kettle of a supercritical CO2 extraction device, and sealing; heating, opening a valve of the extraction kettle when the temperature of the extraction kettle is up to 45-70 DEG C, opening a vent valve to empty air and pressurizing a system when the pressure inside the extraction kettle is equal to that of a storage tank, and controlling the flow rate of CO2 at 35-60L / h and beginning to circularly extract when the pressure of the extraction kettle is up to 30-40Mpa, the pressures of a separation kettle I and a separation kettle II are up to 5-10Mpa and the separation temperature is up to 30-50 DEG C; and after extracting for 60-240 minutes, receiving the extracted total volatile oil extractive of asarum from discharging holes of the separation kettles. A great number of pharmacodynamic tests prove that the total volatile oil extractive of asarum has a remarkable effect on treatment of various chronic coughs and can be used for preparing drugs for treating corresponding diseases.

The invention belongs to the field of biomedicine, and particularly relates to use of lecithin-cholesterol acyltransferase (LCAT) in preparing a drug or a healthcare product for treating and / or preventing the hepatic bone disease. According to the cell and animal experiments, the LCAT can realize reverse cholesterol transport of from osteocyte to hepatocyte, so that osteoporosis is relieved; meanwhile, an abnormal skeletal system in a chronic cirrhosis process further can be relieved, and bone density is increased, so that a brand-new choice and idea is provided for treating chronic hepatic bone disease, and the LCAT has a potential clinical application prospect.

The invention relates to a preparation method for a flame-retardant bamboo-based high-density composite board used for gastrodia elata liquor fermentation. The preparation method includes the following steps including splicing of a bamboo-based board framework, preparation of a bamboo-based chipping glued material, preparation of a bamboo-based board mother blank board body, degreasing, dyeing and drying processing of the bamboo-based board mother blank board body, glue solution dipping, ageing and drying processing of the bamboo-based board mother blank board body, preparation of a bamboo-based board blank board, life preserving of the bamboo-based board blank board and flame-retardant paint spraying, and finally a bamboo-based board finished product material is obtained. By means of the preparation method, the utilization rate of bamboo materials is increased, bamboo-based boards with a high flame retardency rate and high strength are obtained, the current situation that solid wood materials are scarce is effectively relieved, and the use requirement of consumers for the bamboo-based boards is met.

The invention discloses a polypeptide for inhibiting nitric oxide synthase degradation and high blood pressure and application thereof, and belongs to the field of research and development of antihypertensive drugs. The polypeptide of the invention inhibits eNOS ubiquitylation and degradation by combining with eNOS, improves endothelium-dependent relaxation response, and stabilizes blood pressure. In addition, the polypeptide designed in the present invention has the advantages of short sequence and easy synthesis, and has a good application prospect as a new type of antihypertensive drug.

The invention provides a new intervention target for preparing anti-diabetic drugs, and applies irisin to the development of diabetes-related drugs to prepare a better method for treating diabetes. After subcutaneous infusion of irisin in STZ / HFD-induced diabetic mice, fasting blood glucose levels were significantly reduced, insulin sensitivity was significantly increased, and irisin reduced gluconeogenesis and increased glycogen synthesis, indicating that irisin can significantly improve diabetes mellitus It is an effective target for the treatment of diabetes, and can be developed as a new anti-diabetic drug or drug target, providing a new way and means for the detection and treatment of diabetes.

The invention relates to the field of biomedicine, in particular to the application of a polypeptide (Urotensin II, Urotensin II) in the preparation of drugs for treating and / or preventing metabolic syndrome / type 2 diabetes / obesity / diabetic complications. The polypeptide of the present invention has the effects of significantly reducing the specific gravity and weight of tissue fat, improving and alleviating insulin resistance, and lowering blood sugar. The polypeptide has novel effects, is easy to synthesize, and has a low dosage, and has good application and development prospects.

The invention provides an application of astragaloside in preparation of a medicine for preventing Alzheimer's disease. The astragaloside can be astragaloside, an available salt of the astragaloside, a solvate of the astragaloside or an astragaloside derivative. The astragaloside can promote the growth of neurons, improve the expression quantity of NMDAR-CREB signal channel related proteins, inhibit histone hypermethylation, relieve cognitive impairment and achieve the effect of preventing the Alzheimer's disease.

The invention discloses a polypeptide for inhibiting degradation of nitric oxide synthase and hypertension andapplication thereof, and belongs to the field of antihypertensive drug research and development. The polypeptide inhibits ubiquitination degradation of eNOS by being combinedwith the eNOS, improves endothelium-dependent relaxation, and stabilizes the blood pressure. In addition, the polypeptide designed has the advantages of short sequence and easy synthesis, and has a good application prospect as a novel antihypertensive drug.

The invention belongs to novel application in the field of biological medicine, belongs to the field of research of related medicines for Alzheimer's disease, and particularly relates to a small molecule compound and application thereof in preparation of related products for treating or preventing Alzheimer's disease. According to the invention, research results show that a GSK 3 inhibitor IX (6-Bromoindirubin-3'-oxime, BIO) can inhibitGsk3beta so as to inhibit the expression of BACE1 in cells and reduce the production process of A beta protein, so the GSK 3 inhibitor IX can be further utilized to prepare the related products for treating and / or preventing Alzheimer's disease. Thus, a brand-new choice and thought are provided for the medicines for treating the Alzheimer's disease at present, and the selection field of the medicines for treating the Alzheimer's disease is widened.

The invention discloses a Manchurian wildginger total polysaccharide extract with cough-relieving activity and a preparation method and application thereof, belonging to the technical field of medicines. The Manchurian wildginger total polysaccharide extract is prepared by subjecting the root and / or tuber of Manchurian wildginger to extraction with a polar solvent, carrying out ethanol precipitation and then carrying out drying under reduced pressure, wherein the yield and the content of the total polysaccharide are 15 wt% and 60 to 80 wt%, respectively. Through a great number of pharmacodynamic tests, it is proved for the first time that the Manchurian wildginger total polysaccharide extract has a substantial cough inhibiting effect which is close to a treatment effect of codeine and shows a better effect on prolonging the incubation period of cough compared with codeine, and it is found out for the first time that the Manchurian wildginger total polysaccharide extract is capable of reducing sensitivity of cough and inhibiting airway inflammations, has good prevention and treatment effects on a variety of cough and can be used for preparation of drugs used for treating diseases related to cough. The Manchurian wildginger total polysaccharide extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention discloses the application of irisin in the preparation of medicine for treating aplastic anemia. The administration method is intraperitoneal injection, and the dosage is 0.5 μg / g; Because irisin has no species specificity and good histocompatibility, it has no immune rejection in patients with aplastic anemia; it is not only suitable for immune cell-mediated aplastic anemia, but also suitable for non-immune-mediated aplastic anemia Acute aplastic anemia, especially hereditary anemia, provides a new intervention target for the preparation of aplastic anemia drugs. The application of irisin to the development of various types of aplastic anemia-related drugs can provide a new therapeutic target for aplastic anemia. The research on drugs for aplastic anemia provides a new choice and idea, and broadens the field of choice for aplastic anemia drugs.

Provided is a use of lecithin-cholesterol acyltransferase (LCAT) for preparing a drug or a healthcare product for treating and / or preventing hepatic bone disease.

The invention discloses application of marmesine in preparation of a cough relieving medicine. According to the invention, marmesine has an obvious cough relieving effect and is found for the first time; furthermore, the cough relieving manner is a non-central cough relieving manner; side effects of conventional central cough relieving medicines in the aspect of a central nervous system are avoided; the invention provides a brand-new selection and idea for current cough treatment, expands selection fields of cough relieving medicines and also makes a contribution to development in the technical field; the marmesine disclosed by the invention is a compound having a definite chemical structure; for pharmacy, the marmesine can be quantitatively fed and is used for preparing modern dosage forms; and furthermore, the marmesine is high in medicine safety and has a potential to develop the cough relieving medicine.

The invention discloses an asarum total lignan extract and a preparation method and application thereof, belonging to the technical field of medicines. The preparation method comprises the following steps: extracting the root and / or tuber of asarum with a polar solvent and then carrying out concentration and drying so as to obtain an asarum total extract; and dissolving the asarum total extract with water, injecting the dissolved asarum total extract into a macroporous adsorption resin, carrying out gradient elution by using an aqueous ethanol solution, collecting eluate, recovering the solvent and carrying out drying so as to obtain the asarum total lignan extract with a content of 60 to 80 wt%, wherein yield of the asarum total lignan extract is 8.4 wt%. Through a great number of pharmacodynamic tests, it is proved for the first time that the asarum total lignan extract has substantial cough-inhibiting and cough reflex sensitivity-lowering effects which are close to the effects of codeine, and it is found out that the asarum total lignan extract has effects on inhibiting airway inflammations, reducing coughing frequencies and prolonging the incubation period of cough, exerts good prevention and treatment effects on a variety of coughs and can be used for preparation of drugs used for treating diseases related to cough. The asarum total lignan extract has the advantages of definite activity, usage of original plants as experimental materials and low cost.

The invention discloses a process for manufacturing large-breadth plates by using an all-bamboo modified material, which comprises the following steps of: (1), fully clearing way a surface wax layer and an inner hard layer; (2), modifying and laminating bamboo sheets into sheet bamboo materials which are in strips, filaments and fibres and are cracked but not fragile; (3), degreasing, dying and drying the bamboo material; (4), impregnating, ageing and drying the bamboo material; and (5), rearranging and laying the bamboo material to form blanks, and performing hot pressing on the blanks to mold the blanks into the large-breadth plates of the all-bamboo modified material. The large-breadth plates of the all-bamboo modified material are fine and smooth in vein and compact in structure and are applied to the application field of manufacturing all-bamboo furniture, floors, decoration materials and engineering, construction and military materials, and can effectively and greatly save raw materials, energy, labour cost, production field and storage field. At the same time, because the bamboo material is modified, 10 kinds of bamboos can be selected as processing raw materials.

The invention discloses a total volatile oil extractive of asarum, an extraction method of the total volatile oil extractive and an application of the total volatile oil extractive in preparation of drugs for treating chronic coughs, belongs to the field of natural drugs and discloses a total volatile oil extractive of asarum as well as an extraction method and application of the total volatile oil extractive. The method comprises the steps of placing coarse asarum powder into an extraction kettle of a supercritical CO2 extraction device, and sealing; heating, opening a valve of the extraction kettle when the temperature of the extraction kettle is up to 45-70 DEG C, opening a vent valve to empty air and pressurizing a system when the pressure inside the extraction kettle is equal to that of a storage tank, and controlling the flow rate of CO2 at 35-60L / h and beginning to circularly extract when the pressure of the extraction kettle is up to 30-40Mpa, the pressures of a separation kettle I and a separation kettle II are up to 5-10Mpa and the separation temperature is up to 30-50 DEG C; and after extracting for 60-240 minutes, receiving the extracted total volatile oil extractive of asarum from discharging holes of the separation kettles. A great number of pharmacodynamic tests prove that the total volatile oil extractive of asarum has a remarkable effect on treatment of various chronic coughs and can be used for preparing drugs for treating corresponding diseases.

The invention discloses the application of vincetoxicoside B in the preparation of anti-diabetic drugs. The invention provides a novel choice and idea for the existing anti-diabetic drugs, widens the selecting field of the anti-diabetic drugs and contributes to the development of the technical field; the applied vincetoxicoside B of the invention is proved to have remarkable anti-diabetic effect;and the invention is selected from the extract of natural drugs having specific chemical structure, therefore, the feeding is quantifiable in the preparation and the invention is applicable to the preparation of drugs in modern forms.