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Application of polypeptide in treatment of diabetes

A technology for diabetes and diabetic eye disease, applied in the field of biomedicine, can solve problems such as not being able to cope well, and achieve the effect of broadening the selection field, protecting and organ damage, and significant anti-diabetic effect

Inactive Publication Date: 2015-04-22
CHONGQING ACAD OF ANIMAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the application of the combination of these drugs in the treatment of diabetes and its complications, there are still some situations that cannot be well dealt with

Method used

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  • Application of polypeptide in treatment of diabetes
  • Application of polypeptide in treatment of diabetes
  • Application of polypeptide in treatment of diabetes

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Experimental program
Comparison scheme
Effect test

Embodiment

[0029] 1) Preparation of hexapeptide:

[0030] The RRWWCR hexapeptide is chemically synthesized (specifically by solid-phase synthesis, the method can be found in Schnlzer M, Alewood P, Jones A, Alewood D, Kent SBH. In situeutralization in Boc-chemistry solid phase peptide synthesis. Int J Pept Res Ther. 2007;13:31-44), HPLC purity greater than 98%. The hexapeptide powder was dissolved in physiological saline to prepare a 1000 μg / mL solution, which was subpackaged and frozen for later use. Dilute with normal saline to the corresponding concentration when used.

[0031] 2) Experimental steps:

[0032] Select 8-week-old Kunming rats, fast for 12 hours after fasting, and inject 1% streptozotocin solution intraperitoneally at a dose of 120 mg / kg, and fast for 12 hours on the 3rd and 7th days after the injection, respectively. Blood was collected from the tail vein, and the blood glucose concentration of fasting mice was measured using a Johnson & Johnson blood glucose meter. T...

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PUM

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Abstract

The invention relates to the biomedical field, and concretely relates to an application of a polypeptide in the treatment of diabetes, such as an application of a polypeptide represented by SEQ ID NO:1 in the preparation of medicines for treating and / or preventing diabetes and / or diabetic complication or in the preparation of health care products for preventing the diabetes and / or diabetic complications. The polypeptide has a significant anti-diabetic effect, can protect body organs, reduce body organ damages, prolong life and reduce blood sugar, and is administrated in a skin wound wiping manner; and the polypeptide RRWWCR can repair injured tissues of diabetic mice, provides a brand new choice and idea for current anti-diabetic medicines, and broadens the selection field of the anti-diabetic medicines.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of a polypeptide in the treatment of diabetes. Background technique [0002] Diabetes is one of the three difficult diseases in the medical field, and its mortality rate is second only to cardiovascular diseases and malignant tumors in developed countries. Diabetes mellitus is a disease of sugar, fat and protein metabolism disorder caused by various etiologies. The scary thing about diabetes is that it can cause various complications in the later stage, which can cause degeneration and damage to multiple organs and tissues in the body. Among them, the eyes, kidneys, nerves, heart and blood vessels are the most important target organs in the complications induced by diabetes. . Patients can suffer from various complications, such as blindness, renal failure, gangrene of extremities, cardiovascular disease, and cerebrovascular accident. [0003] According to statistics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P3/10A61P27/02A61P13/12A61P17/02A61P9/10A61P9/00
Inventor 沈克飞郑华张邑帆付利芝杨睿曹兰王孝友
Owner CHONGQING ACAD OF ANIMAL SCI
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