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Polypeptide for inhibiting degradation of nitric oxide synthase and high blood pressure and application thereof

A nitric oxide and enzymatic degradation technology, applied in the direction of peptides, drug combinations, peptide/protein components, etc., can solve the problem of reduced activity, achieve short peptide sequences, inhibit the degradation of eNOS, and broaden the selection field.

Active Publication Date: 2022-04-22
SUN YAT SEN UNIV
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  • Abstract
  • Description
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Problems solved by technology

These results suggest that the mechanism of eNOS / NO dysfunction may be related to the decrease of eNOS expression or activity

Method used

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  • Polypeptide for inhibiting degradation of nitric oxide synthase and high blood pressure and application thereof
  • Polypeptide for inhibiting degradation of nitric oxide synthase and high blood pressure and application thereof
  • Polypeptide for inhibiting degradation of nitric oxide synthase and high blood pressure and application thereof

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Embodiment Construction

[0025] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments and accompanying drawings.

[0026] source of biological material

[0027] 1) TAT-PKPREPFD, TAT-PKPREPFD-Rhodamine B, and TAT-PKPREPFD-Flag were all synthesized by Beijing Zhongke Yaguang Biotechnology Co., Ltd.; 2) Fresh and healthy newborn umbilical cords were obtained from the Obstetrics and Gynecology Department of the First Affiliated Hospital of Sun Yat-sen University; 3) African green monkey kidney fibroblast cell line Cos7 was imported from ATCC in the United States and kept in our laboratory; 4) eNOS-GFP plasmid was provided by Professor Kong Deling of Nankai University in Tianjin; 5) C57BL / 6 mice were purchased from the Experimental Animal Center of Sun Yat-sen University.

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Abstract

The invention discloses a polypeptide for inhibiting nitric oxide synthase degradation and high blood pressure and application thereof, and belongs to the field of research and development of antihypertensive drugs. The polypeptide of the invention inhibits eNOS ubiquitylation and degradation by combining with eNOS, improves endothelium-dependent relaxation response, and stabilizes blood pressure. In addition, the polypeptide designed in the present invention has the advantages of short sequence and easy synthesis, and has a good application prospect as a new type of antihypertensive drug.

Description

technical field [0001] The invention relates to the technical field of antihypertensive drugs, in particular to a polypeptide compound and its application, in particular to a polypeptide for inhibiting nitric oxide synthase degradation and hypertension and its application. Background technique [0002] Hypertension is a clinical syndrome characterized by elevated systemic arterial blood pressure. It is an independent risk factor for cardiovascular diseases such as coronary heart disease, stroke, left ventricular hypertrophy, and acute myocardial infarction. Its incidence is increasing year by year. And tend to younger, seriously affecting people's health. Therefore, the prevention and treatment of hypertension has always been one of the hot spots of basic and clinical research. [0003] Vascular endothelial cells are a layer of longitudinal cells between the blood flow and the inside of blood vessels. The integrity of its structure and function is of great significance to t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/06A61K38/08A61P9/12
Inventor 周家国梁思佳吕晓飞商金艳章斐然
Owner SUN YAT SEN UNIV
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