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Application of euphorbitin in preparation of medicine for preventing or treating alcoholic liver diseases

A technology for isozanflavin and alcoholic liver disease, applied in the field of medicine, can solve problems such as no reports, and achieve the effects of improving liver cell damage, reducing oxidative stress, and excellent activity

Inactive Publication Date: 2021-02-12
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no report on the application of eupholzanthin in anti-alcoholic liver disease

Method used

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  • Application of euphorbitin in preparation of medicine for preventing or treating alcoholic liver diseases
  • Application of euphorbitin in preparation of medicine for preventing or treating alcoholic liver diseases
  • Application of euphorbitin in preparation of medicine for preventing or treating alcoholic liver diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] To investigate the effects of eupholzanthin on liver injury, oxidative stress and activity of alcohol metabolizing enzymes in mice

[0023] 1 Experimental materials

[0024] 1.1 Experimental animals

[0025] Sixty healthy male ICR mice weighing 20-25 g were purchased from the Experimental Animal Center of Nantong University. The animals were given free access to food and water, and were given standard pellet feed. They were adaptively reared in a standard photoperiod (12 hours of light, 12 hours of darkness), room temperature 21-25°C, and constant humidity. The water was changed every day, and the litter was changed every other day.

[0026] 1.2 Experimental drugs and reagents

[0027] Isozanthin: Chengdu Purifa Technology Development Co., Ltd., product number: BP0576; sodium carboxymethylcellulose: Sinopharm Chemical Reagent Co., Ltd., product number: 1010670204600. Red Star Erguotou: Beijing Red Star Co., Ltd., barcode: 6906785230868. Chloral hydrate: Sinopharm Ch...

Embodiment 2

[0066] The human liver cell line LO2 was cultured in vitro, treated with alcohol to establish a model of alcohol-induced liver cell injury, and the effects of euprazin on alcohol-induced liver cell viability, injury and intracellular oxidative stress were observed.

[0067] 1 Experimental materials

[0068] 1.1 Experimental cells

[0069] The human hepatocyte LO2 cell line was purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences in Shanghai.

[0070] 1.2 Experimental drugs and reagents

[0071] Dimethyl sulfoxide: Sinopharm Chemical Reagent Co., Ltd., product number: ZA3648001. Absolute ethanol: Sinopharm Chemical Reagent Co., Ltd., product number: 10009259. Dulbecco's modified Eagle medium (DMEM): American Gibico company, item number: 12100-061. Fetal bovine serum: American Gibico Company, product number: 10099. Penicillin G sodium salt: Biosharp Company, product number: BS215B. Streptomycin sulfate: Biosharp company, product number: BS077B. Trypsin...

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Abstract

The invention discloses an application of eupatorin in preparation of a medicine for preventing or treating alcoholic liver diseases, and belongs to the technical field of medicines. According to theinvention, an alcoholic liver disease animal model and a cell model are established through alcohol stimulation, the influence of eupatilin on alcohol-induced hepatocyte damage, oxidative stress and alcohol metabolic enzyme activity is observed, and research finds that eupatilin can significantly reduce alcohol-induced hepatocyte damage in both in-vivo and in-vitro experiments; oxidative stress isrelieved, the activity of alcohol metabolic enzymes is enhanced, and a new thought is provided for preventing and treating alcoholic liver diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of eupholzanthin in the preparation of drugs for preventing or treating alcoholic liver disease. Background technique [0002] With the improvement of people's living standards, the number of people who drink alcohol is increasing day by day, and its incidence is also showing a trend of increasing year by year. It has become the second leading cause of liver damage besides viral hepatitis. Alcohol-induced liver damage will gradually evolve into alcoholic fatty liver, alcoholic hepatitis and liver fibrosis if it is not treated promptly and effectively. According to the statistics of the World Health Organization, more than 80% of heavy drinkers have a certain degree of fatty liver, 10-35% may develop alcoholic hepatitis, and 10-20% will develop liver fibrosis. Therefore, global alcoholic liver disease is a serious threat to human health, and strengthen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P1/16
CPCA61K31/352A61P1/16
Inventor 陆春风包小峰许文萱李明娜吴若曼周莹姜毅铭
Owner NANTONG UNIVERSITY
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