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Use of medicaments for treating cardiac-cerebral vascular diseases and post-stroke syndromes in preparation of medicaments for treating fatty liver

A technology for stroke sequelae and fatty liver, which is applied in the field of medicine for preparing medicine for treating fatty liver

Active Publication Date: 2009-12-30
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no relevant report on the use of this drug for the treatment of cardiovascular and cerebrovascular diseases and sequelae of apoplexy in the treatment of fatty liver

Method used

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  • Use of medicaments for treating cardiac-cerebral vascular diseases and post-stroke syndromes in preparation of medicaments for treating fatty liver
  • Use of medicaments for treating cardiac-cerebral vascular diseases and post-stroke syndromes in preparation of medicaments for treating fatty liver
  • Use of medicaments for treating cardiac-cerebral vascular diseases and post-stroke syndromes in preparation of medicaments for treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: Tablet for treating fatty liver

[0040] Weigh 500g of ginkgo leaves, 500g of salvia miltiorrhiza, 300g of escutellaria, 300g of gynostemma, 400g of hawthorn, 400g of garlic, 200g of notoginseng, 10g of natural borneol, 5.36g of magnesium stearate and 53.5g of starch, and prepare according to the following steps:

[0041] (1) the borneol is pulverized into a fine powder of 120 meshes with an ultrafine pulverizer, for subsequent use;

[0042] (2) After the garlic is soaked and moistened, it is steamed according to the steam distillation method, and the volatile components in the medicinal materials are taken out with the steam distillation, separated, and the garlic volatile oil is collected and clathrated with β-cyclodextrin to obtain clathrate volatile oil cyclodextrin inclusion compound can be prepared by β-cyclodextrin or hydroxyl β-cyclodextrin; if β-cyclodextrin is used, the ratio of volatile oil to β-cyclodextrin is 1g: 5ml ~ 15ml; If hydroxy β-cycl...

Embodiment 2

[0048] Embodiment 2: Granules for the treatment of fatty liver

[0049] Weigh 500g of ginkgo leaves, 500g of salvia miltiorrhiza, 300g of escutellaria, 300g of gynostemma, 400g of hawthorn, 400g of garlic, 200g of notoginseng, 10g of natural borneol, 1200g of sucrose and 20g of starch, and prepare according to the following steps:

[0050] (1) the borneol is pulverized into a fine powder of 120 meshes with an ultrafine pulverizer, for subsequent use;

[0051] (2) After the garlic is soaked and moistened, steam distillation is used to separate the volatile oil, which is clathrated with β-cyclodextrin to obtain an inclusion compound; the preparation of the volatile oil cyclodextrin inclusion compound is the same as in Example 1;

[0052] (3) Grinding Panax notoginseng into 10-mesh coarse powder, set aside;

[0053] (4) Add 60% ethanol to Ginkgo biloba, heat and extract 2 times, each time for 2 hours, reclaim ethanol, add water to the medicinal solution to adjust the relative de...

Embodiment 3

[0057] Embodiment 3: the capsule for the treatment of fatty liver

[0058] Weigh 450g of ginkgo leaves, 450g of salvia miltiorrhiza, 250g of escutellaria, 250g of gynostemma, 350g of hawthorn, 350g of garlic, 150g of notoginseng, 5g of natural borneol and appropriate amount of starch, and prepare according to the following steps:

[0059] (1) the borneol is pulverized into a fine powder of 110 meshes with an ultrafine pulverizer, and set aside;

[0060] (2) After the garlic is soaked and moistened, steam distillation is used to separate the volatile oil, which is clathrated with β-cyclodextrin to obtain an inclusion compound; the preparation of the volatile oil cyclodextrin inclusion compound is the same as in Example 1;

[0061] (3) Grinding Panax notoginseng into 15 mesh coarse powder, set aside;

[0062](4) Add 55% ethanol to Ginkgo biloba, heat and extract 2 times, each time for 2 hours, reclaim ethanol, add water to the medicinal solution to adjust the relative density t...

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PUM

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Abstract

The invention discloses the use of medicaments for treating cardiac-cerebral vascular diseases and post-stroke syndromes in the preparation of medicaments for treating fatty liver. Experiments show that the medicaments for treating the cardiac-cerebral vascular diseases and the post-stroke syndromes have certain lipid regulating effects, can obviously improve hyperlipidemic hepatic steatosis, arenontoxic and are effective medicaments for treating hyperlipidemic fatty liver diseases.

Description

technical field [0001] The present invention relates to a new clinical application of a drug for treating cardio-cerebral system diseases and sequelae of apoplexy (drug name Yindan Xinnaotong), especially the drug for treating cardio-cerebral system diseases and apoplexy sequelae in the preparation of a drug for treating fatty liver The use in the invention belongs to the technical field of traditional Chinese medicines. Background technique [0002] Fatty liver refers to the pathological changes caused by excessive accumulation of fat in liver cells due to various reasons. Fatty liver is a common clinical phenomenon, not an independent disease. Normal intrahepatic fat accounts for 3%-5% of the wet weight of the liver, of which 2 / 3 are phospholipids, and 1 / 3 are triglycerides, cholesterol and fatty acids. Due to various reasons, such as: increased supply of exogenous fatty acids, hypersynthesis of intrahepatic fatty acids, decreased oxidation of hepatic fatty acids, and ob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P1/16A61K31/045
Inventor 李星安斯扬夏文余丽梅吴芹聂晶
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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