Application of 3-methoxyl mangiferin in preparing medicine used for treating post-stroke depression
A technology of methoxy mango, stroke, applied in the field of medicine
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Embodiment 1
[0036] 1 Experimental materials, reagents and instruments
[0037] Experimental animals: 40 healthy SD male rats, weighing (200+10) g, aged 5-6 months. Rats were adaptively fed in a mouse cage for 2 weeks, with free access to food and water, natural circadian rhythm light, and constant temperature (21±2)°C. During training, drink sucrose water and measure the baseline value of sucrose water test and open-field test (OFT), and select 32 rats with similar behavioral scores for the experiment.
[0038] Experimental drugs: 3-methoxymangiferin (Kunming Pharmaceutical, production batch number: 20111115), dissolved in 10% DMSO before use; fluoxetine hydrochloride (Prozac, production batch number: A019602), dissolved in distilled water before use , according to adult dosage (0.33mg·kg -1 d -1 ) 7 times the calculated dosage for rats (2.33mg·kg -1 d -1 ). Immunohistochemical reagents: rabbit anti-5-hydroxytryptamine (5-HT) produced by Beijing Zhongshan Biotechnology Co., Ltd., ra...
Embodiment 2
[0071] Example 2 3-methoxymangiferin freeze-dried powder injection
[0072] Prescription (1000 sticks):
[0073] 3-methoxymangiferin 1g
[0074] Meglumine 3g
[0075] Mannitol 2g
[0076] Packed into 1000 pieces, dissolved in water, and freeze-dried.
Embodiment 3
[0077] Example 3 3-methoxymangiferin freeze-dried powder injection
[0078] Prescription (1000 sticks):
[0079] 3-methoxymangiferin 100g
[0080] β-cyclodextrin 45g
[0081] Mannitol 1.31kg
[0082] Packed into 1000 pieces, dissolved in water, and freeze-dried.
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