Application of 3-methoxyl mangiferin in preparing medicine used for treating post-stroke depression
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A technology of methoxy mango, stroke, applied in the field of medicine
Active Publication Date: 2013-07-10
KPC PHARM INC
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At present, the widely used antidepressants are selective serotonin uptake blockers, including fluoxetine, sequerin, paroxetine, etc., but due to well-known reasons, some adverse effects in the gastrointestinal tract Reactions, such as nausea, vomiting, anorexia, diarrhea, and its liver and kidney toxicity side effects, which limit the clinical appl...
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Embodiment 1
[0036] 1 Experimental materials, reagents and instruments
[0037] Experimental animals: 40 healthy SD male rats, weighing (200+10) g, aged 5-6 months. Rats were adaptively fed in a mouse cage for 2 weeks, with free access to food and water, natural circadian rhythm light, and constant temperature (21±2)°C. During training, drink sucrose water and measure the baseline value of sucrose water test and open-field test (OFT), and select 32 rats with similar behavioral scores for the experiment.
[0038] Experimental drugs: 3-methoxymangiferin (Kunming Pharmaceutical, production batch number: 20111115), dissolved in 10% DMSO before use; fluoxetine hydrochloride (Prozac, production batch number: A019602), dissolved in distilled water before use , according to adult dosage (0.33mg·kg -1 d -1 ) 7 times the calculated dosage for rats (2.33mg·kg -1 d -1 ). Immunohistochemical reagents: rabbit anti-5-hydroxytryptamine (5-HT) produced by Beijing Zhongshan Biotechnology Co., Ltd., ra...
Embodiment 2
[0071] Example 2 3-methoxymangiferin freeze-dried powder injection
[0072] Prescription (1000 sticks):
[0073] 3-methoxymangiferin 1g
[0074] Meglumine 3g
[0075] Mannitol 2g
[0076] Packed into 1000 pieces, dissolved in water, and freeze-dried.
Embodiment 3
[0077] Example 3 3-methoxymangiferin freeze-dried powder injection
[0078] Prescription (1000 sticks):
[0079] 3-methoxymangiferin 100g
[0080] β-cyclodextrin 45g
[0081] Mannitol 1.31kg
[0082] Packed into 1000 pieces, dissolved in water, and freeze-dried.
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Abstract
The invention relates to the field of medicine, and discloses a novel application of 3-methoxyl mangiferin in the field of pharmacy, and a medicine composition comprising 3-methoxyl mangiferin. 3-methoxyl mangiferin can promote hippocampus dentate gyrus neuron 5-hydroxytryptamine 1A receptor gene and protein expressions, and can induce neurotrophic effects such as hippocampus remodeling performed by 5-hydroxytryptamine. Therefore, post-stroke hippocampus nerve aregeneratory can be substantially ameliorated, 5-HT re-uptake of nerve presynaptic membrane can be selectively inhibited, 5-HT positive cell expression at hypothalamus can be reduced, exhaustion of 5-HT can be relieved, and anxiety and depression symptoms caused by 5-HT exhaustion can be relieved. Therefore, 3-methoxyl mangiferin can be used in preparing medicines used for treating post-stroke depression.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the application of 3-methoxymangiferin in the preparation of drugs for treating post-stroke depression. Background technique [0002] 3-Methoxymangiferin, full name 1,6,7-trihydroxy-3-methoxypyrrole-2-C-β-D-glucopyranoside, also known as homomangiferin, is a C-glycoside The xanthone compound exists in plants such as Anacardiaceae mango (Mangifera indica L.), almond (Mangifera persiciformis C.), and its structural formula is as shown in formula I: [0003] [0004] Post-stroke depression (PSD) is an organic affective disorder and one of the most common complications of stroke. It usually has a slow onset, protracted course, and serious harm, but its pathogenesis is still unclear. It is generally believed that the hypofunction of monoaminergic nerves in the brain is the pathophysiological basis of depression after cerebral hemorrhage. At present, the widely used antidepressants are sel...
Claims
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