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390results about How to "Great research value" patented technology

Instruction acquisition control method based on simultaneous multithreading

The invention provides an instruction acquisition control method based on simultaneous multithreading, which includes the steps: in each clock cycle of a processor, reading a PC (personable computer) value of instructions by an instruction acquisition component according to a program counter, selecting two threads with high priority as instruction acquisition threads firstly, and then computing the actual instruction number required by each instruction acquisition thread so as to read the instructions; according to an IPC (inter-process communication) value and the Cache failure rate, enabling a dual-priority resource allocation mechanism to compute system resources required by the threads in an instruction acquisition stage and complete dynamic allocation of the resources; matching a TBHBP (thread branch history branch predictor) with the instruction acquisition operations of the instruction acquisition component, acquiring a pattern type match position Sc by connecting global historical information with local historical information read by a branch instruction Bi to utilize as an index of a secondary PHT (pattern history table), and inputting computed results to a BRT (branch result table); and when the branch instruction Bi is executed again, judging whether CONF fields are larger than or equal to 2 or not by the aid of a selector, directly outputting the recorded branch results if the CONF fields are larger than or equal to 2, and finally placing the acquired instruction into an instruction Cache, so that all operations of instruction acquisition control are completed.
Owner:HARBIN ENG UNIV

Drilling grabbing shovel type combined sampler device for planetoid detection and use method of drilling grabbing shovel type combined sampler device

The invention discloses a drilling grabbing shovel type combined sampler device for planetoid detection and a use method of the drilling grabbing shovel type combined sampler device. The device comprises a feeding mechanism, a drilling mechanism, a grabbing shovel mechanism and a mounting plate. The use method comprises the following steps of (1) resetting a motor; (2) checking the motor; (3) performing sampling by a grabbing shovel motor; (4) detecting a shovel; (5) rotating a drilling rod to downwards move; (6) checking the drilling rod; (7) lifting the drilling rod; (8) checking the drilling rod; (9) performing sampling; (10) checking a sampling pipe; (11) enabling the drilling mechanism to upwards move; (12) checking a micro switch contact; (13) stopping a feeding motor; (14) checking a sampler; (15) arranging samples; (16) checking the shovel; (17) arranging the samples; (18) checking the sampling pipe; and (19) performing resetting. According to the drilling grabbing shovel type combined sampler device for planetoid detection and the use method of the drilling grabbing shovel type combined sampler device, sample collection can be realized on the surface of a planetoid, and deep sampling can be executed; bedding information of the samples can be kept; the device has the advantages of large sampling amount, various sample types, retention of original appearances of the samples and the like.
Owner:BEIHANG UNIV

Targeting polymer micelle containing acid-sensitive subsurface, and preparation method thereof

The invention relates to a targeting polymer micelle containing acid-sensitive subsurface, and a preparation method thereof. The polymer micelle is in a core-shell structure. Targeting ligand molecules are grafted on a hydrophilic segment terminal of the shell, and a hydrophobic anti-tumor medicine is loaded by a hydrophobic segment of the core. An acid-sensitive response subsurface exists between the core and the shell, wherein the acid-sensitive response subsurface can load negative electricity quantum dots. When a pH value is 5.0, the acid-sensitive layer is hydrophobic; when the pH value is 7.4, the acid-sensitive layer is hydrophobic. According to the invention, with the targeting molecules, the tumor targeting function of the micelle is realized; with the quantum dots loaded on the acid-sensitive subsurface, a visualizing function is realized; with low-pH-responsibility of the acid-sensitive subsurface, a controlled-release function can be realized, and the release of the medicine can be controlled. With the micelle system provided by the invention, the release behavior of the medicine is improved, and a premature-release problem of the micelle system in blood circulation ispossible to be solved. With an internalization behavior mediated by the targeting molecules, the treatment effect of the medicine is enhanced. With the loaded quantum dots, monitoring during the treatment process can be realized.
Owner:SUN YAT SEN UNIV

Modeling method and device of compound toxicity prediction model and application of compound toxicity prediction model

The invention provides a modeling method of a compound toxicity prediction model. The modeling method at least comprises the following steps of: S101, providing toxicity classification labels of candidate modeling compounds; S102, providing a molecular descriptor of each candidate modeling compound; S103, providing a target protein descriptor of each candidate modeling compound; S104, providing aquantitative high-throughput screening analysis descriptor of each candidate modeling compound, wherein the quantitative high-throughput screening analysis descriptor is a PubChem activity score of aspecified amount of high-throughput screening; and S105, constructing and training a compound toxicity prediction model. According to the method, physicochemical properties, biological activity and target protein action properties of drug candidate compounds can be fully utilized, and a drug toxicity prediction system is constructed by utilizing statistical modeling advantages of a machine learning algorithm based on ensemble learning, so that the model has interpretability and prediction performance, and has the better physicochemical and biological significance and research value.
Owner:上海尔云信息科技有限公司
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