Depression treating traditional Chinese medicine composition

A technology of composition and traditional Chinese medicine, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, and pharmaceutical formulas, and can solve problems such as large toxic side effects and resistance to western medicines

Inactive Publication Date: 2016-10-26
谭曜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, Western medicines for treating various types of depression mainly include tricyclic antidepressants (TCA for short, divided into imidazines, purines, dibenzozoles, etc.), monoamine oxidase inhibitors (abbreviated as MAOI, such as iprohydrazine, etc.) ) and 5-HT reuptake inhibitors (referred to as SSRI, such as fluoxetine, etc.), but Western medicines generally have disadvantages such as drug resistance and large toxic and side effects. It is natural antidepressants that have become a research hotspot in this field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 This example is a preferred example. The traditional Chinese medicine composition for treating depression consists of the following raw materials in parts by weight: Hypericum perforatum 15g, Curculigo curculigo 5g, Liuyuexue 15g, Bupleurum 7g, Radix Paeoniae Alba 15g, Ginseng 15g, Suanzaoren 7g, Magnolia officinalis 10g, Pinellia 5g, Inula 7g, Reed root 15g, Imperata 20g, Calamus 20g, Maca 17g, Borneolum 5g, Acanthopanax 10g, Keel 7g, Yizhiren 7g, polygala 7g, licorice 3g, wolfberry 3g.

[0038] Decoction with water: put the above 21 traditional Chinese medicines into a casserole, add 600ml of water for the first decoction and soak for 30 minutes, first boil with strong fire, then decoct with slow fire for 30 minutes, take about 350ml of the liquid medicine; add 500ml of water for the second decoction, Boil with strong fire first, then decoct with slow fire for 25 minutes, take about 350ml of the liquid medicine; mix the two decoction liquids and take it twic...

Embodiment 2

[0039] Embodiment 2 Chinese medicine composition of the present invention is to the impact test of mouse desperate behavior

[0040] (1) Purpose of experiment

[0041] Animals will have escaping behaviors in harsh environments, and when they cannot escape, they will appear in desperation. This method is a mouse depression model for evaluating antidepressants that utilizes desperation behaviors. Effects of a Behavioral Mouse Model of Depression.

[0042] (2) Experimental method

[0043] Mouse tail suspension test: ICR mice were divided into 4 groups, i.e. the control group (only give distilled water without giving any medicine), the small dose group of Chinese medicine composition (5.6g crude drug / kg), the middle dose group (11.2g Crude drug / kg), large dose group (22.4g crude drug / kg). According to the dosage, each group of mice was given the medicine of the present invention or distilled water by gavage for 2 weeks, and the mouse tail suspension test was carried out 1.5 hou...

Embodiment 3

[0053] Example 3 The clinical curative effect observation test of the traditional Chinese medicine composition of the present invention in the treatment of depression.

[0054] 1. General information

[0055] 30 patients, including 10 males and 20 females, with a course of 2 weeks to 2 years. Meeting the diagnostic criteria for depressive episodes in the "Chinese Mental Illness Classification Scheme and Diagnostic Criteria", the score of the first 17 items of the Hamilton Depression Scale (HAMD) is ≥ 8 points, and the first-episode patient has not taken antidepressants or psychoactive drugs in the past 1 week Drugs, those who have never received electroconvulsive therapy, patients with depressive episodes of unipolar affective disorder, regardless of gender, aged 18 to 60 years old. Exclude bipolar disorder, depression caused by other reasons, severe suicidal tendencies, those with serious abnormalities in laboratory tests, pregnant or lactating women.

[0056] 2. Treatment ...

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PUM

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Abstract

The invention discloses a depression treating traditional Chinese medicine composition, which is prepared from the following bulk drugs: 10-20 g of hypericum perforatum l, 1-10 g of curculigo orchioides gaertn, 10-20 g of serissa japonica (thunb.) thunb, 5-10 g of radix bupleuri, 10-20 g of cynanchum otophyllum, 10-20 g of ginseng, 5-10 g of ziziphus jujuba mill.var.spinosa, 5-15 g of magnolia officinalis, 1-10 g of processed pinellia ternata, 5-10 g of inula japonica thunb, 10-20 g of rhizoma phragmitis, 15-25 g of rhizoma imperatae, 15-25 g of acorus tatarinowii, 15-20 g of maca, 1-10 g of borneol, 5-15 g of acanthopanax obovatus hoo, 5-15 g of dragon's bone, 5-10 g of fructus alpiniae oxyphyllae, 10-15 g of polygala tenuifolia willd, 1-5 g of licorice root, and 1-5 g of Chinese wolfberry. According to the present invention, the traditional Chinese medicine composition can be prepared into the clinically suitable oral preparation, has effects of liver qi replenishing, phlegm removing and depression relieving, can effectively treat depression symptoms such as depressive emotion and the like, and has characteristics of significant treatment effect and no toxic-side effect.

Description

technical field [0001] The invention relates to the field of Chinese herbal medicines, in particular to a Chinese medicine composition for treating depression. Background technique [0002] Depression is a common mental illness that currently plagues people. It is mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, worrying about suffering from various diseases, feeling There are many discomforts throughout the body, and in severe cases, suicidal thoughts and behaviors may appear. Its pathogenesis is complex and related to various factors such as heredity, environment and society. With the continuous development of society, the pace of modern life continues to accelerate, the pressure and competition faced by people in daily life and work are increasing day by day, the occurrence of depression is gradually increasing, and it has become a mental disease that seriously endangers human physical and men...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61P25/24A61K35/02A61K31/045
CPCA61K36/185A61K31/045A61K35/02A61K36/233A61K36/254A61K36/258A61K36/28A61K36/282A61K36/31A61K36/41A61K36/47A61K36/484A61K36/575A61K36/65A61K36/69A61K36/71A61K36/725A61K36/74A61K36/815A61K36/88A61K36/888A61K36/8888A61K36/899A61K36/9062A61K2300/00
Inventor 谭曜陈有为黄姣陈平朱杰单伟光
Owner 谭曜
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