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105 results about "Upper third" patented technology

Methods for providing neuroprotection for the animal central nervous system against the effects of ischemia, neurodegeneration, trauma, and metal poisoning

Methods and pharmaceutical compositions for preconditioning and/or providing neuroprotection to the animal central nervous system against the effects of ischemia, trauma, metal poisoning and neurodegeneration, including the associated cognitive, behavioral and physical impairments. In one embodiment, the method is accomplished by stimulating and stabilizing hypoxia-inducible factor-1α (HIF-1α). HIF-1α is known to provide a neuroprotective benefit under ischemic conditions. Patients at risk for certain diseases or disorders that are associated with risk for cerebral ischemia may benefit, e.g., those at risk for Alzheimer's disease, Parkinson's disease, Wilson's disease or stroke or those patients having head or spinal cord injury. Patients undergoing certain medical procedures that may result in ischemia may also benefit. Initially, the possibility of ischemia or neurodegeneration is recognized. Intranasal therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and/or copper such as iron chelators, copper chelators, and antioxidants. A particular example of such therapeutic agents is the iron chelator deferoxamine (DFO). Intranasal administration of DFO is known to stimulate and/or stabilize HIF-1α and provides an efficient and safe method for pre-conditioning the brain to protect against cerebral ischemia. Moreover, DFO is shown to decrease weight loss in subjects when administered pre and/or post stroke.
Owner:HEALTHPARTNERS RESEACH FOUND

Methods and pharmaceutical compositions for differentially altering gene expression to provide neuroprotection for the animal central nervous system against the effects of ischemia, neurodegeneration, trauma and metal poisoning

ActiveUS20070092500A1Preventing and minimizing and treating neurologic complicationAvoid side effectsOrganic active ingredientsBiocideAntioxidantNose
Methods and pharmaceutical compositions for preconditioning and/or providing neuroprotection to the animal central nervous system against the effects of neurological disorders involving ischemia, trauma, metal poisoning and neurodegeneration, including the associated cognitive, behavioral and physical impairments. In one embodiment, the method is accomplished by stimulating and/or stabilizing hypoxia-inducible factor-1α (HIF-1α). HIF-1α is known to provide a neuroprotective benefit under ischemic conditions. In another embodiment, the method is accomplished by differentially reducing, inhibiting or preventing the increased expression of selected genes caused by neurological disorders. Patients at risk for certain diseases or disorders that are associated with risk for cerebral ischemia may benefit, e.g., those at risk for Alzheimer's disease, Parkinson's disease, Wilson's disease, Huntington's disease, thalassemia or stroke, or those patients having head or spinal cord injury. Patients undergoing certain medical procedures that may result in ischemia may also benefit. Initially, the possibility of ischemia or neurodegeneration is recognized. Intranasal therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and/or copper such as iron chelators, copper chelators, and antioxidants. Particular examples of such therapeutic agents are the iron chelators deferoxamine (DFO) and deferasirox. Intranasal administration of DFO is known to stimulate and/or stabilize HIF-1α and provides an efficient and safe method for pre-conditioning the brain to protect against cerebral ischemia.
Owner:HEALTHPARTNERS RESEACH FOUND

Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia

Methods and pharmaceutical compositions for preconditioning and / or providing neuroprotection to the animal central nervous system against the effects of ischemia, trauma, metal poisoning and neurodegeneration, including the associated cognitive, behavioral and physical impairments. In one embodiment, the method is accomplished by stimulating and stabilizing hypoxia-inducible factor-1α (HIF-1α). HIF-1α is known to provide a neuroprotective benefit under ischemic conditions. Patients at risk for certain diseases or disorders that are associated with risk for cerebral ischemia may benefit, e.g., those at risk for Alzheimer's disease, Parkinson's disease, Wilson's disease or stroke or those patients having head or spinal cord injury. Patients undergoing certain medical procedures that may result in ischemia may also benefit. Initially, the possibility of ischemia or neurodegeneration is recognized. Intranasal therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and / or copper such as iron chelators, copper chelators, and antioxidants. A particular example of such therapeutic agents is the iron chelator deferoxamine (DFO). Intranasal administration of DFO is known to stimulate and / or stabilize HIF-1α and provides an efficient and safe method for pre-conditioning the brain to protect against cerebral ischemia. Moreover, DFO is shown to decrease weight loss in subjects when administered pre and / or post stroke.
Owner:HEALTHPARTNERS RESEACH FOUND

Method of treating Alzheimer's disease comprising administering deferoxamine (DFO) to the upper one-third of the nasal cavity

ActiveUS7776312B2Avoid side effectsStimulate and stabilize HIF-1αBiocideOrganic active ingredientsNervous systemNose
Methods and pharmaceutical compositions for preconditioning and / or providing neuroprotection to the animal central nervous system against the effects of neurological disorders involving ischemia, trauma, metal poisoning and neurodegeneration, including the associated cognitive, behavioral and physical impairments. In one embodiment, the method is accomplished by stimulating and / or stabilizing hypoxia-inducible factor-1α (HIF-1α). HIF-1α is known to provide a neuroprotective benefit under ischemic conditions. In another embodiment, the method is accomplished by differentially reducing, inhibiting or preventing the increased expression of selected genes caused by neurological disorders. Patients at risk for certain diseases or disorders that are associated with risk for cerebral ischemia may benefit, e.g., those at risk for Alzheimer's disease, Parkinson's disease, Wilson's disease, Huntington's disease, thalassemia or stroke, or those patients having head or spinal cord injury. Patients undergoing certain medical procedures that may result in ischemia may also benefit. Initially, the possibility of ischemia or neurodegeneration is recognized. Intranasal therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and / or copper such as iron chelators, copper chelators, and antioxidants. Particular examples of such therapeutic agents are the iron chelators deferoxamine (DFO) and deferasirox. Intranasal administration of DFO is known to stimulate and / or stabilize HIF-1α and provides an efficient and safe method for pre-conditioning the brain to protect against cerebral ischemia.
Owner:HEALTHPARTNERS RESEACH FOUND

Symmetrical roller type fodder crushing machining device

InactiveCN108325597APrevent solidarity without blankingReduce the phenomenon of slipping and not crushingFeeding-stuffTransportation and packagingDrive shaftEngineering
The invention discloses a symmetrical roller type fodder crushing machining device. The upper portion of a device body is provided with a material bucket, the upper portion of the right side of the device body is provided with a driving motor, and the lower portion of the driving motor is rotationally connected with a driving shaft; the upper portion of the drying shaft is fixedly connected with the first bevel gear; a second bevel gear is fixedly connected with a driven shaft, a driven shaft bearing is rotationally connected with the side wall of the material bucket, and the left end of the driven shaft is fixedly connected with a semi-circular bevel gear; and the left side of the semi-circular bevel gear is provided with two third bevel gears, a toothed part of the semi-circular bevel gear is meshed with the third bevel gears, and the third bevel gears are fixedly connected with a threaded sleeve. According to the symmetrical roller type fodder crushing machining device, the semi-circular bevel gear drives the upper third bevel gear and the lower third bevel gear to rotate forwards and reversely in a reciprocating mode, accordingly, the threaded sleeve is driven to rotate forwards and reversely, the threaded sleeve drives a screw rod and a movable transverse plate to move up and down, partition panels are driven to swing back and forth through connection rods, and accordingly, intermittent discharging is achieved; and a worm drives a worm wheel and a driving roller to rotate for crushing, crushing is more thorough, the transmission torque of the worm and the worm wheel islarge, and the phenomenon that the driving roller slides and cannot crush fodder is avoided.
Owner:赵志坚

Combined cabinet

InactiveCN104172750ASave spaceThe space is enlarged without losing the beautySofasCouchesEngineeringBed boards
The invention provides a combined cabinet, which comprises a cabinet body, wherein the cabinet body is formed by a closet and a bed cabinet; the closet and the bed cabinet respectively have a set of cabinet door; the inner part of the closet is respectively arranged to be an upper cabinet body, a middle cabinet body and a lower cabinet body from top to bottom; the upper cabinet body is connected with the middle cabinet body through a second clapboard; the middle cabinet body is connected with the lower cabinet body through a first clapboard; a horizontal clothes rail is arranged on the lower end of the first clapboard; a control mechanism is arranged at the one third part of the side plate from bottom to top shared by the lower cabinet body and the bed cabinet; a bed body is arranged in the bed cabinet, and is formed by a bed plate, a bed rest, a bed mattress and support bed legs. The combined cabinet has the beneficial effects that the bed cabinet and the closet are effectively combined into a whole, so that not only is the space saved, but also the furniture in the house is ensured to be complete; when being needed, the bed body is put down for use, and when being not needed, the bed body is put into the bed cabinet, so that the space is enlarged without losing attractiveness, and the demand of people is fully met.
Owner:TIANJIN ZHONGBAI HONGLIN TECH
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