48results about How to "Minimizes delivery" patented technology

Methods for treating anatomic tissue defects such as a patent foramen ovate generally involve positioning a distal end of a catheter device at the site of the defect, exposing a housing and energy transmission member from the distal end of the catheter, engaging the housing with tissues at the site of the defect, applying suction or other approximating tool to the tissue via the housing to bring the tissue together, and applying energy to the tissue with the energy transmission member or to deliver a clip or fixation device to substantially close the defect. Apparatus generally include a catheter body, a housing extending from a distal end of the catheter body for engaging tissue at the site of the defect, and further adapted to house a fusing or fixation device such as an energy transmission member adjacent a distal end of the housing, or a clip or fixation delivery element.

Disrupting tissue and devices and systems for disrupting tissue. The disclosure describes ways to deliver moieties to a target tissue, where the target tissue in general is not at the point of introduction, in such a way that minimal damage is produced in the tissue at the point of introduction. In some embodiments this is accomplished by jetting fluid at high velocity into the target tissue. The disclosure further describes novel agents deliverable in such systems for use in remodeling tissues. Some of these agents comprise a liquid while others do not. Additionally, although not specifically described in detail much of the disclosure may additionally be used in the delivery of therapeutic drugs.

Controlled release oral dosage forms are provided for the continuous, sustained administration of a pharmacologically active agent to the upper gastrointestinal tract of a patient in whom the fed mode as been induced. The majority of the agent is delivered, on an extended release basis, to the stomach, duodenum and upper regions of the small intestine, with drug delivery in the lower gastrointestinal tract and colon substantially restricted. The dosage form comprises a matrix of a biocompatible, hydrophilic, erodible polymer with an active agent incorporated therein, wherein the polymer is one that both swells in the presence of water and gradually erodes over a time period of hours, with swelling and erosion commencing upon contact with gastric fluid, and drug release rate primarily controlled by erosion rate.

An emergency oxygen supply system for use on aircraft in the event of a loss in cabin pressure is configured for delivering allotments of oxygen and timing the delivery such allotments to each passenger so as maximize the efficiency of the transfer of such oxygen into the passenger's bloodstream. The delivery of each allotment is selected so that the entire allotment is available for inhalation into the region of the lung most efficient at oxygen transfer while the volume of the allotment is selected to substantially coincide with the volume of such region of the lung.

Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.

An object of the invention is to provide a method for delivery of macromolecules into biological cells in the tissues of a patient and includes the steps of: (a) providing electrodes (16) in an electrode assembly (12), wherein the electrodes have fixed electrode surfaces (42) which are coated with at least one static layer of electrode releasable molecules (44) to be delivered; (b) providing a waveform generator (15) for generating electric fields; (c) establishing electrically conductive pathways between the electrodes (16) and the waveform generator (15); (d) locating the electrodes (16) such that the biological cells are situated therebetween, and (g) providing electric fields in the form of pulse waveforms from the waveform generator (15) to the electrodes (16), such that molecules in the at least one static layer of the electrode releasable molecules (44) on the electrodes (16) are delivered into the biological cells. The electrode releasable molecules (44) can be either electric field separable molecules and/or solvent separable material. Another object of the invention is to provide an apparatus for carrying out the method of the invention. The static-coated electrode assembly (12) can be provided in a sterile package (24), from which the electrode assembly (12) is removed prior to use. The statically-coated electrode assembly (12) can be in a form of a disposable assembly (12) which is removable and replaceable from an electrode assembly holder (13).

The invention concerns a nasal cannula assembly (10) adapted to deliver gases to a patient comprising a first compartment (1) and a second compartment (2) separated by a separation wall (6); a pair of nasal prongs (5) in fluid communication with the first compartment (1); the first compartment (1) comprising a first inlet (11) for introducing a first gas into said first compartment (1); the second compartment (2) comprising a second inlet (2) for introducing a second gas into said second compartment (2); and the separation wall (6) comprising at least one valve element (3) for controlling the passage of gas from the second compartment (2) to the first compartment (1). The invention concerns also a breathing assistance apparatus comprising a source of NO gas, and said nasal cannula assembly (10) in fluid communication with said source of NO gas.

The invention concerns a nasal cannula assembly (10) adapted to deliver gases to a patient comprising a first compartment (1) and a second compartment (2) separated by a separation wall (6); a pair of nasal prongs (5) in fluid communication with the first compartment (1); the first compartment (1) comprising a first inlet (11) for introducing a first gas into said first compartment (1); the second compartment (2) comprising a second inlet (2) for introducing a second gas into said second compartment (2); and the separation wall (6) comprising at least one flow restriction element (35) for controlling the passage of gas from the second compartment (2) to the first compartment (1).

The present invention includes compounds that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound and/or composition of the invention.

The invention concerns a breathing assistance apparatus having a source of Nitric Oxide in fluid communication with a nasal cannula assembly (10) adapted to deliver gases to a patient comprising a first compartment (1) and a second compartment (2) separated by a separation wall (6); a pair of nasal prongs (5) in fluid communication with the first compartment (1); the first compartment (1) comprising a first inlet (11) for introducing a first gas into said first compartment (1); the second compartment (2) comprising a second inlet (2) for introducing a second gas into said second compartment (2); and the separation wall (6) comprising at least one flow restriction element (35) for controlling the passage of gas from the second compartment (2) to the first compartment (1).

Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., from nicotine. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into skin. A dose of agent is delivered from the assembly into skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel agent out of the assembly. During a second period, a second current having a characteristic to attract agent is used to retain agent in the assembly such that delivery of agent into skin is minimized. In particular embodiments, a dose of agent may be delivered on-demand using an input from the patient using an inhalation sensing device which mimics an inhaled form of tobacco.

Monitoring continuous repetitive web sheet defects to determine the causes of such defects by creating unique diagnostic patterns associated with selected components of a web-making machine and employing pattern recognition techniques to analyze and classify web-sheet dynamic and deterministic defect patterns, and identify their root causes. Corrective actions can be effected thereby enhancing machine run-time to minimize late deliveries and improves overall product quality. The technique which is integrated with quality control system can be applied to the manufacturer of paper, packaging, rubber sheets, plastic film, metal foil, and the like.

A method of transportation and storage of wind energy, comprising receiving wind energy from a wind turbine in the form of compressed gas, storing of at least a portion of the compressed gas in a pipe, venting a portion of the compressed gas to drive a motor to drive a generator to generate electrical power, and distributing the electrical power to one or more users.

The present invention includes pyrimido[5,4-d]pyrimidines that are useful in the prevention and/or treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method of preventing and/or treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention. The present invention further includes a method of preventing destabilization or stabilizing breathing rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of the invention.

A knife for creating berms in agricultural fields for strip-till farming is improved by adding wings on opposing sides of the knife edge that are configured to fracture and raise soil in a wider path for building a berm behind the knife. The wings can be swept back, angled downward from front to back, and angled downward from inside to outside, for better loosening compacted soil below the surface and creating improved berms rearward of the knife. The knife edge can be replaceable by removal of a single pin. If a difficult object is encountered, such as large rocks or tree roots, the knife can swing reward with respect to a supporting shank to minimize damage to the knife. Upon swinging reward, an agricultural product delivery tube rearward of the knife for depositing agricultural product into the berm can swing forward to minimize crimping of the delivery tube.

The present invention relates to a foldable desk, in which a desk board is movable in front and back directions so as to fit a body shape of a user and a chair and a desk are completely foldable and overlap for space utilization, and a frame 50 of a desk board 10 is rotatably connected to a desk board support frame 60 through a connection rod 13, the desk board support frame 60 is bent at a right angle in a state where the desk board 10 is accurately positioned at a position, at which the desk board 10 exerts a function of a desk, and a first upper edge 62 of a desk board support frame having a larger length than a thickness of the desk board and a first upper edge 32 of the connection frame simultaneously support a bottom surface of the desk board 10, a connection rod 13 is shorter than a second upper edge 64 of the desk board support frame 60 coupled to the connection rod 13 to allow the desk board 10 to slide next to the first upper edge 62 of the desk board support frame, and the desk board 10 is bent downwardly at a right angle in the state where the desk board 10 has slide next to the first upper edge 62 of the desk board support frame, when a chair seat 40 is in an accurately positioned state, in which the chair seat 40 serves as a chair, a bottom surface of the chair sheet is supported to a support part 35 protruding to an inner side of a second upper edge 34 lower than the first upper edge 32 of the connection frame 30, and the chair sheet 40 is completely folded upwardly and overlap a backrest 20, and a backrest support frame 70 is foldable at a right angle so as to overlap the connection frame 30 in the state where the chair seat 40 is folded upwardly, and the protruding part 35 is positioned in a space between a first leg and a second leg 72 and 74 of the backrest support frame in the folded state of the backrest support frame 70.