118 results about "Neuro degeneration" patented technology

The present invention relates to methods and medicaments used for treating conditions that require axonal regeneration, e.g. in mammals affected by injury or disease of the central or peripheral nervous system. The medicaments used in these methods facilitate axonal regeneration by inhibition of the complement system. Conditions requiring axonal regeneration that may be treated in accordance with the invention include physical injuries as well as neurodegenerative disorders of the peripheral or central nervous system.

The object of the invention is a contact lens for pseudo-aphakic eyes and / or eyes with macular and retinal degeneration, its main characteristic being the application of a yellow filter to a standard contact lens, with the purpose of protecting the eye from the short wavelength radiation of the visible spectrum (lower than 500 nm).This invention avoids the difficulties and risks of existing techniques, providing protection to the cataract-operated eye and improving natural protection in eyes with retinal neuro-degeneration, through the simple application of a contact lens.The invention consists of the combination of a standard contact lens and yellow filter, which absorbs short wavelengths of 350 / 500 nm, both its components being appropriate for use in the human eye.

A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.

The inventors have discovered a collection of proteinaceous biomarkers (“AD biomarkers) which can be measured in peripheral biological fluid samples to aid in the diagnosis of neurodegenerative disorders, particularly Alzheimer's disease and mild cognitive impairment (MCI). The invention further provides methods of identifying candidate agents for the treatment of Alzheimer's disease by testing prospective agents for activity in modulating AD biomarker levels.