Down syndrome critical region 1-like protein

Inactive Publication Date: 2003-10-02
INCYTE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

0085] Hybridization probes are also useful in mapping the naturally occurring genomic sequence. The probes may be hybridized to a particular chromosome, a specific region of a chromosome, or an artificial chromosome c

Problems solved by technology

In subjects with advanced Alzheimer's disease, accumulating plaques damage the neuronal architecture in limbic areas and eventually cripple the memory process.
Inheritance of some gene polymorphisms is also linked to increased risk of

Method used

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  • Down syndrome critical region 1-like protein
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  • Down syndrome critical region 1-like protein

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examples

[0180] The examples below are provided to illustrate the subject invention and are not included for the purpose of limiting the invention. For purposes of example, the preparation of the human hippocampal cDNA libraries, HIPONOT01, and a normalized library, HIPONON02, prepared from HIPONOT01 are described.

[0181] I Representative cDNA Preparation

[0182] HIPONOT01 cDNA Library

[0183] The human hippocampal cDNA library, HIPONOT01, was constructed from tissue obtained from the hippocampus of a 72-year-old Caucasian female who died from an intracranial hemorrhage. The frozen tissue was homogenized and lysed in TRIZOL reagent (1 g tissue / 10 ml reagent; Invitrogen), using a POLYTRON homogenizer (Brinkmann Instruments, Westbury N.Y.). Following homogenization, chloroform was added (1:5 v / v), and the lysate was centrifuged. The aqueous layer was removed, and the RNA was precipitated with isopropanol. The RNA was resuspended in DEPC-treated water and digested with DNAse I (Invitrogen) for 25 mi...

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Abstract

The invention provides a Down syndrome critical region 1-like 1 protein, its encoding cDNAs, and antibodies that specifically bind the protein. The invention also provides for the use of these compositions in the diagnosis, prognosis, treatment and evaluation of progression and treatment of neurodegenerative disorders.

Description

[0001] This application is a continuation-in-part of U.S. Ser. No. 09 / 614,474 filed Jul. 11, 2000.[0002] This invention relates to Down syndrome critical region 1-like 1 protein, its encoding cDNA, and an antibody that specifically bind the protein and their use in the diagnosis, prognosis, treatment and evaluation of the progression and treatment of neurodegenerative disorders, and in particular, Alzheimer's disease.[0003] Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the formation of senile plaques and neurofibrillary tangles containing amyloid beta peptide. These plaques are found in limbic and association cortices of the brain, including hippocampus, temporal cortices, cingulate cortex, amygdala, nucleus basalis and locus caeruleus. Early in Alzheimer's pathology, physiological changes are visible in the cingulate cortex (Minoshima et al. (1997) Annals of Neurology 42:85-94). In subjects with advanced Alzheimer's disease, accumulating p...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61K38/00A61K45/00A61K48/00A61P25/28C07K14/47C07K16/18C12M1/00C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09C12N15/12C12P21/02C12Q1/68G01N33/15G01N33/50G01N33/53G01N37/00
CPCA61K38/00A61K48/00C12Q2600/158C12Q1/6883C07K14/47A61P25/28
Inventor LORING, JEANNE F.TINGLEY, DEBORA W.EDWARDS, CARLA M.STREETER, DAVID G.
Owner INCYTE
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