1results about How to "Large Stokes shift" patented technology

This invention discloses indole-fused hydrogenated morpholino compounds, their preparation methods, and applications, belonging to the technical fields of fluorescent materials and antitumor compounds. Using enamine ketones and amines as reaction substrates, a series of indole-fused hydrogenated morpholino compounds with different substituents were synthesized in highly polar solvents via the Stork enamine reaction and intramolecular acylation reaction. These compounds exhibit fluorescence wavelengths in the range of 430-700 nm and show certain inhibitory activity against lung cancer A549, breast cancer MDA-MB-231, colon cancer HCT116, liver cancer HepG2, and prostate cancer DU145, providing more options for the preparation of tumor drugs.